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ClinicalTrials.gov 12 recruiting now early-phase tilt

Concussion, Brain: early-phase trial registry

12 of 21 indexed Concussion, Brain trials are currently recruiting, with more weight in Phase 1-2.

Corpus placement: #797 of 28,707 conditions by registered trial count.

21 US clinical trials · 12 currently recruiting · #797 of 28,707 conditions by registered trial count

Concussion, Brain: 21 US clinical trials tracked, 12 recruiting.

Concussion, Brain is the subject of 21 registered US clinical trials on ClinicalTrials.gov, 12 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 5 in Phase 1-2 (earlier-stage). The most active sponsor is Seattle Children's Hospital, running 3 of these trials.

Enrollment posture brief

Registry condition concussion-brain

OPEN 12 | RECR 57% | LATE 0 | EARLY 5 | RANK #797 | SPON 3

Nearest open-share peer: ACL (57% recruiting · 7 trials)

Concussion, Brain (this)57%Anal Cancer42.9%Allergic Conjunctivitis14.3%Attention Deficit Disorder W4.8%Adult Acute Myeloid Leukemia0%
Open-enrollment share among volume-matched conditions near Concussion, Brain

Concussion, Brain lists 12 open slots (57% of 21 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Concussion, Brain on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Concussion, Brain is recruiting above its size-band peers.

    12 of 21 indexed trials (57.1%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. Sponsorship of Concussion, Brain trials is spread across many organizations.

    Seattle Children's Hospital accounts for 3 of 21 trials (14.3%). 17 distinct sponsors appear on at least one study for this condition label.

  3. Typical Concussion, Brain enrolment sits around 98 participants.

    Median target enrolment is 98 among the 21 trials that report a genuine target (sentinel values excluded). 11 of those (52.4%) plan for fewer than 100 participants.

  4. Concussion, Brain research is mostly interventional.

    18 interventional and 3 observational studies make up this index (85.7% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 25

Open and recent trials

21 total, page 1 of 1

RECRUITING 500 participants

Risk Stratification in Children With Concussion

Duke University

NCT05825027

RECRUITING NA 360 participants

CBT-I vs. MBTI for Traumatic Brain Injury (TBI)-Related Insomnia and Post-Traumatic Stress Symptoms

Johns Hopkins University

NCT05663034

RECRUITING NA 304 participants

Concussion Health Improvement Program

Seattle Children's Hospital

NCT06036147

RECRUITING Phase 2 216 participants

Modulating Exercise Dosage to Improve Concussion Recovery

University of Colorado, Denver

NCT05434130

RECRUITING Phase 2 150 participants

BCAAs in Concussion 2.0

Akiva Cohen

NCT06829498

RECRUITING NA 130 participants

A Pragmatic Rehabilitation Intervention: The Active Rehab Study

University of North Carolina, Chapel Hill

NCT05320822

RECRUITING Phase 2 75 participants

Personalized Brain Stimulation to Treat Chronic Concussive Symptoms

University of California, Los Angeles

NCT06073886

RECRUITING Phase 2 75 participants

Pathways Relating Amnestic MCI to a Mild Traumatic Brain Injury History

University of Texas Southwestern Medical Center

NCT05446584

RECRUITING NA 72 participants

Combined Neuromodulation and Cognitive Training for Post-mTBI Depression

University of California, San Diego

NCT05682677

RECRUITING NA 46 participants

The Influence of Prescribed Exercise on Pain Related Fear Following Concussion in Collegiate Athletes

University of Virginia

NCT06246669

RECRUITING Phase 2 42 participants

Growth Hormone Replacement Therapy for Retried Professional Football Players

Center for Neurological Studies

NCT04121780

RECRUITING NA 20 participants

Creatine Supplementation in Concussion Recovery

San Diego State University

NCT06208813

ACTIVE NOT RECRUITING 660 participants

Follow-up of MTBI Patients Discharged from the ED Using Standard Clinical Triage Including BrainScope One

BrainScope Company

NCT04279431

ACTIVE NOT RECRUITING NA 200 participants

Mobile Subthreshold Exercise Program for Concussion--R01

Seattle Children's Hospital

NCT04688255

COMPLETED 268 participants

Objective Brain Function Assessment of mTBI/Concussion

BrainScope Company

NCT03963804

COMPLETED NA 251 participants

Role of Rehabilitation in Concussion Management: A Randomized Controlled Trial

University of North Carolina, Chapel Hill

NCT02988596

COMPLETED NA 98 participants

Developing an Implementation Strategy for Post-concussion Communication With Low Health Literacy Parents in the Emergency Department

Seattle Children's Hospital

NCT04112914

COMPLETED NA 72 participants

Concussion Prevention in Female Soccer Athletes

Children's Hospital Medical Center, Cincinnati

NCT03014492

COMPLETED NA 60 participants

Salivary Biomarkers for Concussion Recovery

State University of New York at Buffalo

NCT05379920

COMPLETED NA 50 participants

Efficacy of Brock String Therapy Post Concussion

University of Pittsburgh

NCT04076657

COMPLETED NA 41 participants

The Effects of a Sub-maximal Exercise Program on Adolescents Who Sustained a Concussion

Boston Children's Hospital

NCT03170856

Phase Distribution

PhaseTrial count
Phase 2 5

Named interventions

Most-linked intervention names on Concussion, Brain records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Placebo Other
2 trials
BrainScope Ahead 300iP Device
1 trials
Low Volume Aerobic Exercise Behavioral
1 trials
High Volume Aerobic Exercise Behavioral
1 trials
Enhanced Graded Exertion Other
1 trials
Multidimensional Active Rehabilitation Other
1 trials
Brock String Therapy Behavioral
1 trials
Sub-maximal exercise Other
1 trials

US sites by state

Facility locations filed on Concussion, Brain trials. A trial with sites in several states counts in each.

North Carolina 4 trials
Washington 3 trials
Texas 3 trials
Michigan 3 trials
California 3 trials
Virginia 2 trials
Pennsylvania 2 trials
New York 2 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Concussion, Brain page

21 registered trials, 12 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Concussion, Brain condition card totals 21 registered trials; most-linked intervention Placebo; top US site state North Carolina. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.