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COMPLETED NA

Salivary Biomarkers for Concussion Recovery

NCT05379920 · View on ClinicalTrials.gov ↗

Study Summary

The overarching purpose of this proposed research is to determine whether BDNF and/or specific miRNAs can serve as biomarkers for recovery from a concussion during prescribed exercise. The investigators hypothesize salivary BDNF and specific miRNA signatures will change in a statistically significant manner as participants proceed from injury to recovery and participants who show recovery in ANS regulation will show significant differences in salivary BDNF and specific miRNA expression. This study also aims to determine if BDNF and/or specific miRNA can serve as biomarkers of the return of ANS function in concussed patients. The basic premise here is that the volume of exercise will significantly affect the rate of change in the expression of salivary BDNF and miRNA from injury to recovery.

Conditions Studied

Interventions

  • BEHAVIORAL High Volume Aerobic Exercise
  • BEHAVIORAL Low Volume Aerobic Exercise

Study Locations (1)

New York

  • UB MD Orthopeadics & Sports Medicine — Buffalo

Trial Details

FieldValue
Enrollment Target 60 participants
Start Date 2022-03-22
Est. Completion 2023-01-13
Phase NA

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05379920

The ClinicalTrials.gov registry entry for NCT05379920 describes a study currently listed as completed. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 60 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is State University of New York at Buffalo, which has 234 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Concussion, Brain appearing as the primary indexed condition, and to 2 interventions — of which High Volume Aerobic Exercise is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05379920 reports 1 study location spanning 1 distinct geographic area — top geographies include New York. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05379920 about?

NCT05379920 is a clinical study titled "Salivary Biomarkers for Concussion Recovery". The overarching purpose of this proposed research is to determine whether BDNF and/or specific miRNAs can serve as biomarkers for recovery from a concussion during prescribed exercise. The investigators hypothesize salivary BDNF and specific miRNA signatures will change in a statistically significan...

What is the current status of trial NCT05379920?

This trial is currently completed. It is a NA study. The enrollment target is 60 participants. The study started on 2022-03-22. Estimated completion is 2023-01-13.

What conditions does trial NCT05379920 study?

This clinical trial studies the following conditions: Concussion, Brain. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05379920?

The interventions under investigation include: High Volume Aerobic Exercise (BEHAVIORAL), Low Volume Aerobic Exercise (BEHAVIORAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05379920?

This trial is sponsored by State University of New York at Buffalo, which has 234 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05379920 being conducted?

This trial has 1 study location across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial