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NCT04229992 · ClinicalTrials.gov registry record · NA
Calcium: Magnesium Balance, Microbiota, and Necroptosis and Inflammation
A NA study of Colorectal Cancer, sponsored by Vanderbilt University Medical Center.
- Completed
- Registry status
- NA
- Development phase
- 250
- Enrollment target
- 1
- Study location
NCT04229992: Completed NA study of Colorectal Cancer, sponsored by Vanderbilt University Medical Center.
NCT04229992 is a NA study of Colorectal Cancer that has completed, run by Vanderbilt University Medical Center. The registered enrollment target is 250 participants, below the 1,544-participant average among 381 other Colorectal Cancer trials with a reported enrollment target (84% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04229992, a NA study of Colorectal Cancer, has completed, sponsored by Vanderbilt University Medical Center.
- COMPLETED
- Registry status
- NA
- Development phase
- 250 participants
- Enrollment target
- 1
- Study location
Study Summary
Transient receptor potential melastatin 7 (TRPM7), a magnesium (Mg) -regulated chanzyme possessing both ion channel and kinase activities, has a much stronger affinity to Mg2+ than calcium (Ca)2+. We previously reported that individuals with the TRPM7 GA/AA genotype and consumed diets high in Ca:Mg ratio had an increased risk of colorectal polyps. The TRPM7 gene was also observed to possess "driver" mutations that contribute to developing multiple cancers. However, the molecular mechanism remains unclear. To identify if the gut microbiota plays a role in this association, we will investigate whether optimizing Ca:Mg intake ratios to 2.3 altered the abundance of the microbes (e.g. associated with TRPM7 genotype and the risk of metachronous polyps) at the genus level in at least one sample type among stool, swab and tissue in a double-blind 2x2 factorial (TRPM7 genotype and Ca:Mg ratios) randomized trial (Personalized Prevention of Colorectal Cancer Trial, NCT01105169).
Primary Outcome
changes=value at 12 weeks minus value at baseline. Difference between post-treatment and baseline, means increase or reduced the abundance of genera Prevotella in the test samples (rectal mucosa or rectal swab or stool).
Conditions Studied
Interventions
- DIETARY_SUPPLEMENT Placebo
- DIETARY_SUPPLEMENT Magnesium glycinate
Study Locations (1)
Tennessee
- Vanderbilt University Medical Center - Nashville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 250 participants |
| Start Date | 2017-05-05 |
| Est. Completion | 2024-03-28 |
| Phase | NA |
What the finished NCT04229992 record still lists
NCT04229992 is an interventional study that assigns participants to a tested intervention. The registered 250 participants enrollment target is mid-sized for trials with a published cap, below the 1,544-participant average among 381 other Colorectal Cancer trials with a reported enrollment target (84% lower).
The record links to 1 condition, with Colorectal Cancer appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT04229992 reports a single indexed study location in Tennessee.
Frequently Asked Questions
What is clinical trial NCT04229992 about?
NCT04229992 is a clinical study titled "Calcium: Magnesium Balance, Microbiota, and Necroptosis and Inflammation". Transient receptor potential melastatin 7 (TRPM7), a magnesium (Mg) -regulated chanzyme possessing both ion channel and kinase activities, has a much stronger affinity to Mg2+ than calcium (Ca)2+. We previously reported that individuals with the TRPM7 GA/AA genotype and consumed diets high in Ca:Mg ...
What is the current status of trial NCT04229992?
This trial is currently completed. It is a NA study. The enrollment target is 250 participants. The study started on 2017-05-05. Estimated completion is 2024-03-28.
What conditions does trial NCT04229992 study?
This clinical trial studies the following conditions: Colorectal Cancer.
What interventions are being tested in trial NCT04229992?
The interventions under investigation include: Placebo (DIETARY_SUPPLEMENT), Magnesium glycinate (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT04229992?
This trial is sponsored by Vanderbilt University Medical Center, which has 677 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04229992 being conducted?
This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Colorectal Cancer
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04229992's enrollment target sits among peer trials
250 129th of 381 higher than 253 of 381 other Colorectal Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Colorectal Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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