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NCT00351975 · ClinicalTrials.gov registry record · Phase 1
Belinostat and Azacitidine in Treating Patients With Advanced Hematologic Cancers or Other Diseases
A Phase 1 study of Chronic Myelomonocytic Leukemia and Chronic Myelogenous Leukemia, BCR-ABL1 Positive, sponsored by National Cancer Institute (NCI).
- Completed
- Registry status
- Phase 1
- Development phase
- 56
- Enrollment target
- 4
- Study locations
NCT00351975: Completed Phase 1 study of Chronic Myelomonocytic Leukemia and Chronic Myelogenous Leukemia, BCR-ABL1 Positive, sponsored by National Cancer Institute (NCI).
NCT00351975 is a Phase 1 study of Chronic Myelomonocytic Leukemia and Chronic Myelogenous Leukemia, BCR-ABL1 Positive that has completed, run by National Cancer Institute (NCI). The registered enrollment target is 56 participants, below the 88-participant average among 73 other Chronic Myelomonocytic Leukemia trials with a reported enrollment target (36% lower). The trial reports 4 study locations across 4 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00351975, a Phase 1 study of Chronic Myelomonocytic Leukemia and Chronic Myelogenous Leukemia, BCR-ABL1 Positive, has completed, sponsored by National Cancer Institute (NCI).
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 56 participants
- Enrollment target
- 4
- Study locations
Study Summary
This phase I trial is studying the side effects and best dose of belinostat when given together with azacitidine in treating patients with advanced hematologic cancers or other diseases. Belinostat may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the cancer. Drugs used in chemotherapy, such as azacitidine, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving belinostat together with azacitidine may kill more cancer cells.
Primary Outcome
Graded using the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 3.0 or 4.0.
Conditions Studied
Interventions
- DRUG Azacitidine
- OTHER Laboratory Biomarker Analysis
- DRUG Belinostat
Study Locations (4)
Illinois
- University of Chicago Comprehensive Cancer Center - Chicago
Wisconsin
- University of Wisconsin Hospital and Clinics - Madison
Ontario
- University Health Network-Princess Margaret Hospital - Toronto
Canterbury
- Princess Margaret Hospital - Cashmere
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 56 participants |
| Start Date | 2006-06 |
| Est. Completion | 2013-03 |
| Phase | Phase 1 |
What the finished NCT00351975 record still lists
NCT00351975 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 56 participants, a relatively small participant target, below the 88-participant average among 73 other Chronic Myelomonocytic Leukemia trials with a reported enrollment target (36% lower).
The record links to 10 conditions, with Chronic Myelomonocytic Leukemia appearing as the primary indexed condition, and to 3 interventions - of which Azacitidine is the first listed.
NCT00351975 reports a single indexed study location in Illinois, Wisconsin, Ontario.
Frequently Asked Questions
What is clinical trial NCT00351975 about?
NCT00351975 is a clinical study titled "Belinostat and Azacitidine in Treating Patients With Advanced Hematologic Cancers or Other Diseases". This phase I trial is studying the side effects and best dose of belinostat when given together with azacitidine in treating patients with advanced hematologic cancers or other diseases. Belinostat may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth and by bloc...
What is the current status of trial NCT00351975?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 56 participants. The study started on 2006-06. Estimated completion is 2013-03.
What conditions does trial NCT00351975 study?
This clinical trial studies the following conditions: Chronic Myelomonocytic Leukemia, Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11, Adult Acute Myeloid Leukemia With t(16;16)(p13.1;q22); CBFB-MYH11, Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative.
What interventions are being tested in trial NCT00351975?
The interventions under investigation include: Azacitidine (DRUG), Laboratory Biomarker Analysis (OTHER), Belinostat (DRUG).
Who is sponsoring clinical trial NCT00351975?
This trial is sponsored by National Cancer Institute (NCI), which has 3,257 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00351975 being conducted?
This trial has 4 study locations across Illinois, Wisconsin, Ontario, Canterbury. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Chronic Myelomonocytic Leukemia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00351975's enrollment target sits among peer trials
56 34th of 73 higher than 40 of 73 other Chronic Myelomonocytic Leukemia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Chronic Myelomonocytic Leukemia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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