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Dasatinib (BMS-354835) Versus Imatinib Mesylate in Subjects With Chronic Myeloid Leukemia
NCT00103844 · View on ClinicalTrials.gov ↗
Study Summary
The primary purpose of this study is to estimate the major cytogenetic response rates of BMS-354825 and imatinib (800 mg/d) in subjects with chronic phase, Philadelphia chromosome positive, chronic myeloid leukemia (PH+ CML) with disease resistant to imatinib at a dose of 400-600 mg/d.
Conditions Studied
Interventions
- DRUG Dasatinib
- DRUG Imatinib
Study Locations (20)
California
- Local Institution — Anaheim
- Local Institution — Bakersfield
- Local Institution — Fullerton
- Local Institution — Loma Linda
- Local Institution — Los Angeles
- Local Institution — Monterey Park
- Local Institution — San Diego
- Local Institution — Santa Barbara
- Local Institution — Santa Maria
- Local Institution — Stanford
- Local Institution — Vallejo
Georgia
- Local Institution — Athens
- Local Institution — Atlanta
- Local Institution — Lawrenceville
Florida
- Local Institution — Jacksonville
- Local Institution — Tampa
Alabama
- Local Institution — Birmingham
Colorado
- Local Institution — Aurora
Connecticut
- Local Institution — Hartford
District of Columbia
- Local Institution — Washington D.C.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 150 participants |
| Start Date | 2005-02 |
| Est. Completion | 2008-03 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00103844
The ClinicalTrials.gov registry entry for NCT00103844 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 150 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Bristol-Myers Squibb, which has 504 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Chronic Myeloid Leukemia appearing as the primary indexed condition, and to 2 interventions — of which Dasatinib is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT00103844 reports 20 study locations spanning 7 distinct geographic areas — top geographies include California, Georgia, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT00103844 about?
NCT00103844 is a clinical study titled "Dasatinib (BMS-354835) Versus Imatinib Mesylate in Subjects With Chronic Myeloid Leukemia". The primary purpose of this study is to estimate the major cytogenetic response rates of BMS-354825 and imatinib (800 mg/d) in subjects with chronic phase, Philadelphia chromosome positive, chronic myeloid leukemia (PH+ CML) with disease resistant to imatinib at a dose of 400-600 mg/d.
What is the current status of trial NCT00103844?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 150 participants. The study started on 2005-02. Estimated completion is 2008-03.
What conditions does trial NCT00103844 study?
This clinical trial studies the following conditions: Chronic Myeloid Leukemia, Philadelphia-Positive Myeloid Leukemia. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT00103844?
The interventions under investigation include: Dasatinib (DRUG), Imatinib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT00103844?
This trial is sponsored by Bristol-Myers Squibb, which has 504 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT00103844 being conducted?
This trial has 20 study locations across Alabama, California, Colorado, Connecticut, District of Columbia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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