Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Brain Metastases, Adult

Open-data reference.

15 US clinical trials · 13 currently recruiting

Active & Recent Trials

RECRUITING 300 participants

Circulating Biomarkers Repository in Adults Diagnosed With Primary and Metastatic Brain Tumors

Duke University

NCT05480644

RECRUITING NA 244 participants

Comparing Single vs Multiple Dose Radiation for Cancer Patients With Brain Metastasis and Receiving Immunotherapy

Wake Forest University Health Sciences

NCT05703269

RECRUITING Phase 2 150 participants

Prophylactic Anti-Seizure Medication vs No Anti-Seizure Medication for Patients With Primary Motor Cortex Brain Metastases

Ayal A. Aizer, MD

NCT07130786

RECRUITING Phase 1 134 participants

Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis

Neonc Technologies

NCT06047379

RECRUITING 119 participants

Developing a New MRI Technique to Understand Changes in Brain Tumors After Treatment

Memorial Sloan Kettering Cancer Center

NCT05559853

RECRUITING Phase 2 62 participants

A Study of Stereotactic Radiosurgery (SRS) for People With Lung Cancer That Has Spread to the Brain

Memorial Sloan Kettering Cancer Center

NCT05419076

RECRUITING Phase 2 60 participants

UCSD Image-Guided Cognitive-Sparing Radiosurgery for Brain Metastases

Jona Hattangadi-Gluth

NCT04343157

RECRUITING Phase 2 60 participants

Stereotactic Radiation for Growing/Changing Brain Metastases With Same-Day Radiation Planning and Treatment With Margin Reduction

Ayal A. Aizer, MD

NCT07132190

RECRUITING Phase 1 46 participants

18F-Fluciclovine PET Amino Acid Evaluation of Brain Metastasis Treated With Stereotactic Radiosurgery

Baptist Health South Florida

NCT06048094

RECRUITING Phase 1 46 participants

Effect of Azeliragon Combined With Stereotactic Radiation Therapy in Patients With Brain Metastases

Baptist Health South Florida

NCT05789589

RECRUITING Phase 1 41 participants

Study of Stereotactic Radiosurgery With Olaparib Followed by Durvalumab and Physician's Choice Systemic Therapy in Subjects With Breast Cancer Brain Metastases

Colette Shen

NCT04711824

RECRUITING NA 40 participants

Multi-disciplinary Care for Brain Metastases

University of Vermont Medical Center

NCT06280300

RECRUITING Phase 1 20 participants

Assess Use of 18F-Fluciclovine for Patients With Large Brain Metastases Treated With Staged Stereotactic Radiosurgery

Baptist Health South Florida

NCT04689048

ACTIVE NOT RECRUITING NA 20 participants

A Phase II Study of Pre-Op SRS Followed by Surgical Resection for Brain Metastases

Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

NCT05341739

ACTIVE NOT RECRUITING Early Phase 1 11 participants

A Study of 68Ga-PSMA-11 PET Scans in People With Brain Tumors

Memorial Sloan Kettering Cancer Center

NCT06209567

Phase Distribution

PhaseTrial count
Early Phase 1 6
Phase 2 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Brain Metastases, Adult Trial Landscape

ClinicalTrials.gov lists 15 US studies indexed under Brain Metastases, Adult, and 13 of those are currently open to recruitment — roughly 87% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Brain Metastases, Adult shows 0 late-stage studies (Phase 3 and Phase 4 combined) alongside 10 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Brain Metastases, Adult is led by Baptist Health South Florida with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 15 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Brain Metastases, Adult?

PlainTrial tracks 15 US clinical trials for Brain Metastases, Adult, of which 13 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Brain Metastases, Adult?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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