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ClinicalTrials.gov 13 recruiting now official registry

Cystic Fibrosis (CF) clinical trials

Every US clinical trial registered for Cystic Fibrosis (CF) — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

15 US clinical trials · 13 currently recruiting

The research picture

Cystic Fibrosis (CF) has 15 registered US clinical trials, 13 of them open to new participants right now — about 87% of the total.

13
recruiting participants now
87%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
2
top sponsor: Indiana University

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 600 participants

TIDES 2.0: Prevalence and Longitudinal Course of Depression, Anxiety, and Behavior Problems in Children With Cystic Fibrosis Under 12 Years of Age

State University of New York at Buffalo

NCT07048574

RECRUITING 260 participants

Kidney Function in People With Cystic Fibrosis in the Era of HEMT

University of Virginia

NCT06595420

RECRUITING 220 participants

Lung Disease and Its Affect on the Work of White Blood Cells in the Lungs

University of Florida

NCT01851642

RECRUITING 200 participants

Studying the Presence of CFRD Complications With Thoughtful Recruitment (SPeCTRuM)

Jaeb Center for Health Research

NCT06837181

RECRUITING Phase 4 95 participants

Ensuring Access to Optimal Therapy in CF: The ENACT Study

Arkansas Children's Hospital Research Institute

NCT07148739

RECRUITING NA 80 participants

CF Wellness Program

Johns Hopkins University

NCT07071324

RECRUITING NA 70 participants

CGM Dynamic Index for Predicting Prediabetes in Cystic Fibrosis

Indiana University

NCT06642610

RECRUITING Phase 3 64 participants

Sinonasal Therapies and Histologic Correlations of Patients With Cystic Fibrosis in the Era of Highly Effective Modulator Therapy

Indiana University

NCT06996951

RECRUITING Phase 2 63 participants

Study With Phage for CF Subjects With Pseudomonas Lung Infection

BiomX

NCT06998043

RECRUITING NA 60 participants

ACT With CF Self-Help Toolkit

Thomas Jefferson University

NCT07436351

RECRUITING NA 60 participants

OnTrackCF: Engagement, Feasibility, and Acceptability Study

Boston Children's Hospital

NCT07031323

RECRUITING NA 30 participants

Personalized Mobile Health Platform to Promote Physical Activity in Adolescents and Young Adults With Cystic Fibrosis

Nemours Children's Clinic

NCT06616857

RECRUITING Phase 2 16 participants

Proof-of-concept Study to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of SION-719 When Added to Trikafta

Sionna Therapeutics

NCT07108153

COMPLETED Phase 2 151 participants

Safety, Tolerability and Efficacy of MP-376 Given for 28 Days to Cystic Fibrosis (CF) Patients

Amgen

NCT00677365

COMPLETED 5 participants

: TRANSITION: An Observational Study of Transition From Lumacaftor/Ivacaftor to Tezacaftor/Ivacaftor (Tez/Iva)

National Jewish Health

NCT03445793

Phase Distribution

PhaseTrial count
Phase 2 3
Phase 3 1
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Cystic Fibrosis (CF) Trial Landscape

ClinicalTrials.gov lists 15 US studies indexed under Cystic Fibrosis (CF), and 13 of those are currently open to recruitment — roughly 87% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Cystic Fibrosis (CF) shows 2 late-stage studies (Phase 3 and Phase 4 combined) alongside 3 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Cystic Fibrosis (CF) is led by Indiana University with 2 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 15 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Cystic Fibrosis (CF)?

PlainTrial tracks 15 US clinical trials for Cystic Fibrosis (CF), of which 13 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Cystic Fibrosis (CF)?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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