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Cystic Fibrosis (CF) clinical trials
Every US clinical trial registered for Cystic Fibrosis (CF) — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
15 US clinical trials · 13 currently recruiting
The research picture
Cystic Fibrosis (CF) has 15 registered US clinical trials, 13 of them open to new participants right now — about 87% of the total.
- 13
- recruiting participants now
- 87%
- of trials open to enrollment
- 2
- in Phase 3–4 (later-stage)
- 2
- top sponsor: Indiana University
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
TIDES 2.0: Prevalence and Longitudinal Course of Depression, Anxiety, and Behavior Problems in Children With Cystic Fibrosis Under 12 Years of Age
State University of New York at Buffalo
NCT07048574
Kidney Function in People With Cystic Fibrosis in the Era of HEMT
University of Virginia
NCT06595420
Lung Disease and Its Affect on the Work of White Blood Cells in the Lungs
University of Florida
NCT01851642
Studying the Presence of CFRD Complications With Thoughtful Recruitment (SPeCTRuM)
Jaeb Center for Health Research
NCT06837181
Ensuring Access to Optimal Therapy in CF: The ENACT Study
Arkansas Children's Hospital Research Institute
NCT07148739
CF Wellness Program
Johns Hopkins University
NCT07071324
CGM Dynamic Index for Predicting Prediabetes in Cystic Fibrosis
Indiana University
NCT06642610
Sinonasal Therapies and Histologic Correlations of Patients With Cystic Fibrosis in the Era of Highly Effective Modulator Therapy
Indiana University
NCT06996951
Study With Phage for CF Subjects With Pseudomonas Lung Infection
BiomX
NCT06998043
ACT With CF Self-Help Toolkit
Thomas Jefferson University
NCT07436351
OnTrackCF: Engagement, Feasibility, and Acceptability Study
Boston Children's Hospital
NCT07031323
Personalized Mobile Health Platform to Promote Physical Activity in Adolescents and Young Adults With Cystic Fibrosis
Nemours Children's Clinic
NCT06616857
Proof-of-concept Study to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of SION-719 When Added to Trikafta
Sionna Therapeutics
NCT07108153
Safety, Tolerability and Efficacy of MP-376 Given for 28 Days to Cystic Fibrosis (CF) Patients
Amgen
NCT00677365
: TRANSITION: An Observational Study of Transition From Lumacaftor/Ivacaftor to Tezacaftor/Ivacaftor (Tez/Iva)
National Jewish Health
NCT03445793
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 3 |
| Phase 3 | 1 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Cystic Fibrosis (CF) Trial Landscape
ClinicalTrials.gov lists 15 US studies indexed under Cystic Fibrosis (CF), and 13 of those are currently open to recruitment — roughly 87% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Cystic Fibrosis (CF) shows 2 late-stage studies (Phase 3 and Phase 4 combined) alongside 3 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Cystic Fibrosis (CF) is led by Indiana University with 2 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 15 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Cystic Fibrosis (CF)?
PlainTrial tracks 15 US clinical trials for Cystic Fibrosis (CF), of which 13 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Cystic Fibrosis (CF)?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.