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ClinicalTrials.gov official registry

Adult Glioblastoma clinical trials

All 15 indexed Adult Glioblastoma trials have closed enrollment.

15 US clinical trials ·

Adult Glioblastoma is the subject of 15 registered US clinical trials on ClinicalTrials.gov, none currently recruiting. 0 are in Phase 3-4 (later-stage) and 14 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 7 of these trials.

The research picture

Adult Glioblastoma has 15 registered US clinical trials; none are currently listed as recruiting, so most are completed or in follow-up.

0
recruiting participants now
0%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
7
top sponsor: National Cancer Institute (NCI)
Phase 111Phase 23

Active & Recent Trials

15 total, page 1 of 1

ACTIVE NOT RECRUITING Phase 1 83 participants

Vorinostat and Temozolomide in Treating Patients With Malignant Gliomas

National Cancer Institute (NCI)

NCT00268385

ACTIVE NOT RECRUITING Phase 1 50 participants

TORC1/2 Inhibitor MLN0128 and Bevacizumab in Treating Patients With Recurrent Glioblastoma or Advanced Solid Tumors

National Cancer Institute (NCI)

NCT02142803

ACTIVE NOT RECRUITING Phase 1 28 participants

A Study of RNA-lipid Particle (RNA-LP) Vaccines for Newly Diagnosed Pediatric High-Grade Gliomas (pHGG) and Adult Glioblastoma (GBM)

University of Florida

NCT04573140

COMPLETED Phase 1 136 participants

Erlotinib in Treating Patients With Recurrent Malignant Glioma or Recurrent or Progressive Meningioma

National Cancer Institute (NCI)

NCT00045110

COMPLETED Phase 1 69 participants

Erlotinib and Temsirolimus in Treating Patients With Recurrent Malignant Glioma

National Cancer Institute (NCI)

NCT00112736

COMPLETED Phase 2 56 participants

Erlotinib and Sorafenib in Treating Patients With Progressive or Recurrent Glioblastoma Multiforme

National Cancer Institute (NCI)

NCT00445588

COMPLETED Phase 2 44 participants

GDC-0449 in Treating Patients With Recurrent Glioblastoma Multiforme That Can Be Removed by Surgery

National Cancer Institute (NCI)

NCT00980343

COMPLETED Phase 2 33 participants

Dovitinib in Treating Patients With Recurrent or Progressive Glioblastoma

Manmeet Ahluwalia, MD

NCT01753713

COMPLETED Phase 1 25 participants

18F-FPPRGD2 PET/CT or PET/MRI in Predicting Early Response in Patients With Cancer Receiving Anti-Angiogenesis Therapy

Sanjiv Sam Gambhir

NCT01806675

COMPLETED 20 participants

Molecular Profiling in Guiding Individualized Treatment Plan in Adults With Recurrent/Progressive Glioblastoma

University of California, San Francisco

NCT02060890

COMPLETED Phase 1 17 participants

Alisertib and Fractionated Stereotactic Radiosurgery in Treating Patients With Recurrent High Grade Gliomas

Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University

NCT02186509

COMPLETED Phase 1 16 participants

Genetically Modified Neural Stem Cells, Flucytosine, and Leucovorin for Treating Patients With Recurrent High-Grade Gliomas

City of Hope Medical Center

NCT02015819

COMPLETED Phase 1 15 participants

A Pilot Feasibility Study of Oral 5-Fluorocytosine and Genetically-Modified Neural Stem Cells Expressing E.Coli Cytosine Deaminase for Treatment of Recurrent High Grade Gliomas

City of Hope Medical Center

NCT01172964

COMPLETED Phase 1 12 participants

Radiation Therapy and Gadolinium Texaphyrin in Treating Patients With Supratentorial Glioblastoma Multiforme

National Cancer Institute (NCI)

NCT00004262

COMPLETED Phase 1 7 participants

Bafetinib in Treating Patients With Recurrent High-Grade Glioma or Brain Metastases

City of Hope Medical Center

NCT01234740

Phase Distribution

PhaseTrial count
Phase 1 11
Phase 2 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Adult Glioblastoma Trial Landscape

15 indexed Adult Glioblastoma studies · 0 recruiting (0%).

Phase mix: 0 late (III/IV) vs 14 early (I/II).

Top sponsor: National Cancer Institute (NCI) (7 trials), 6 others listed. 15 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Adult Glioblastoma?

PlainTrial tracks 15 US clinical trials for Adult Glioblastoma, of which 0 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Adult Glioblastoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.