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NCT04343157 · ClinicalTrials.gov registry record · Phase 2
UCSD Image-Guided Cognitive-Sparing Radiosurgery for Brain Metastases
A Phase 2 study of Cancer and Brain Metastases, Adult, sponsored by Jona Hattangadi-Gluth.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 60
- Enrollment target
- 1
- Study location
NCT04343157: Recruiting Phase 2 study of Cancer and Brain Metastases, Adult, sponsored by Jona Hattangadi-Gluth.
NCT04343157 is a Phase 2 study of Cancer and Brain Metastases, Adult that is actively recruiting participants, run by Jona Hattangadi-Gluth. The registered enrollment target is 60 participants, below the 3,491-participant average among 615 other Cancer trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04343157, a Phase 2 study of Cancer and Brain Metastases, Adult, is actively recruiting participants, sponsored by Jona Hattangadi-Gluth.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 60 participants
- Enrollment target
- 1
- Study location
Study Summary
In this proposal, the investigators introduce advanced diffusion and volumetric imaging techniques along with innovative, automated image parcellation methods to identify critical brain regions, incorporate into cognitive-sparing SRS, and analyze biomarkers of radiation response. This work will advance the investigators' understanding of neurocognitive changes after brain SRS and help create interventions that preserve cognitive-function in brain metastases patients.
Primary Outcome
To evaluate the change from baseline to 3-month post-SRS verbal memory performance when performing relative sparing of eloquent white matter tracts and hippocampi from high doses during brain SRS in patients with 1 to 3 brain metastases. Verbal memory outcomes and measurements include: Hopkins Verbal Learning Test-Revised (HVLT-R)-Immediate, Delayed Recall. Scale of scores is 0-36 for Immediate, 0-12 for Delayed. For both tests, higher scores indicate better performance.
Conditions Studied
Interventions
- RADIATION Cognitive Sparing Brain Stereotactic Radiosurgery (SRS)
Study Locations (1)
California
- Moores Cancer Center - San Diego
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2019-05-01 |
| Est. Completion | 2024-12-31 |
| Phase | Phase 2 |
What NCT04343157 shows while recruiting
NCT04343157 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 3,491-participant average among 615 other Cancer trials with a reported enrollment target (98% lower).
The record links to 3 conditions, with Cancer appearing as the primary indexed condition, and to 1 intervention - of which Cognitive Sparing Brain Stereotactic Radiosurgery (SRS) is the first listed.
NCT04343157 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT04343157 about?
NCT04343157 is a clinical study titled "UCSD Image-Guided Cognitive-Sparing Radiosurgery for Brain Metastases". In this proposal, the investigators introduce advanced diffusion and volumetric imaging techniques along with innovative, automated image parcellation methods to identify critical brain regions, incorporate into cognitive-sparing SRS, and analyze biomarkers of radiation response. This work will adva...
What is the current status of trial NCT04343157?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 60 participants. The study started on 2019-05-01. Estimated completion is 2024-12-31.
What conditions does trial NCT04343157 study?
This clinical trial studies the following conditions: Cancer, Brain Metastases, Adult, Neurocognitive Function.
What interventions are being tested in trial NCT04343157?
The interventions under investigation include: Cognitive Sparing Brain Stereotactic Radiosurgery (SRS) (RADIATION).
Who is sponsoring clinical trial NCT04343157?
This trial is sponsored by Jona Hattangadi-Gluth, which has 2 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04343157 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Cancer
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04343157's enrollment target sits among peer trials
60 393rd of 615 higher than 208 of 615 other Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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