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NCT02852655 · ClinicalTrials.gov registry record · Phase 1
A Pilot Surgical Trial To Evaluate Early Immunologic Pharmacodynamic Parameters For The PD-1 Checkpoint Inhibitor, Pembrolizumab (MK-3475), In Patients With Surgically Accessible Recurrent/Progressive Glioblastoma
A Phase 1 study of Brain Cancer, sponsored by Dana-Farber Cancer Institute.
- Active
- Registry status
- Phase 1
- Development phase
- 60
- Enrollment target
- 7
- Study locations
NCT02852655: Active Phase 1 study of Brain Cancer, sponsored by Dana-Farber Cancer Institute.
NCT02852655 is a Phase 1 study of Brain Cancer that is active but no longer recruiting, run by Dana-Farber Cancer Institute. The registered enrollment target is 60 participants, below the 506-participant average among 47 other Brain Cancer trials with a reported enrollment target (88% lower). The trial reports 7 study locations across 5 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02852655, a Phase 1 study of Brain Cancer, is active but no longer recruiting, sponsored by Dana-Farber Cancer Institute.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 60 participants
- Enrollment target
- 7
- Study locations
Study Summary
This research study is studying an immunotherapy as a possible treatment for Glioblastoma.
Primary Outcome
To measure changes in tumor infiltrating T lymphocyte (TIL) density, defined as % total cells. It will be assessed using pooled Group A and Group B patients.
Conditions Studied
Interventions
- DRUG MK-3475
Study Locations (7)
California
- University of California, Los Angeles - Los Angeles
- University of California, San Francisco - San Francisco
Massachusetts
- Massachusetts General Hospital - Boston
- Dana Farber Cancer Institute - Boston
New York
- Memorial Sloan-Kettering Cancer - New York
Texas
- UT, MD Anderson Cancer Center - Houston
Utah
- Huntsman Cancer Institute - Salt Lake City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2016-09-21 |
| Est. Completion | 2026-07-31 |
| Phase | Phase 1 |
What the registry record for NCT02852655 still lists
NCT02852655 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 506-participant average among 47 other Brain Cancer trials with a reported enrollment target (88% lower).
The record links to 1 condition, with Brain Cancer appearing as the primary indexed condition, and to 1 intervention - of which MK-3475 is the first listed.
NCT02852655 lists 7 locations in 5 states (California, Massachusetts, New York).
Frequently Asked Questions
What is clinical trial NCT02852655 about?
NCT02852655 is a clinical study titled "A Pilot Surgical Trial To Evaluate Early Immunologic Pharmacodynamic Parameters For The PD-1 Checkpoint Inhibitor, Pembrolizumab (MK-3475), In Patients With Surgically Accessible Recurrent/Progressive Glioblastoma". This research study is studying an immunotherapy as a possible treatment for Glioblastoma.
What is the current status of trial NCT02852655?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 60 participants. The study started on 2016-09-21. Estimated completion is 2026-07-31.
What conditions does trial NCT02852655 study?
This clinical trial studies the following conditions: Brain Cancer.
What interventions are being tested in trial NCT02852655?
The interventions under investigation include: MK-3475 (DRUG).
Who is sponsoring clinical trial NCT02852655?
This trial is sponsored by Dana-Farber Cancer Institute, which has 781 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02852655 being conducted?
This trial has 7 study locations across California, Massachusetts, New York, Texas, Utah. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Brain Cancer
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT02852655's enrollment target sits among peer trials
60 20th of 47 higher than 26 of 47 other Brain Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Brain Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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