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ClinicalTrials.gov 37 recruiting now official registry

Bipolar Disorder clinical trials

37 of 163 indexed Bipolar Disorder trials are currently recruiting.

163 US clinical trials · 37 currently recruiting

Bipolar Disorder is the subject of 163 registered US clinical trials on ClinicalTrials.gov, 37 of them currently open to new participants. 45 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 11 of these trials.

The research picture

Bipolar Disorder has 163 registered US clinical trials, 37 of them open to new participants right now, about 23% of the total.

37
recruiting participants now
23%
of trials open to enrollment
45
in Phase 3–4 (later-stage)
11
top sponsor: Massachusetts General Hospital
Phase 13Phase 212Phase 323Phase 422

Active & Recent Trials

163 total, page 4 of 4

COMPLETED Phase 4 25 participants

Geodon in Weight Loss Study for Bipolar Disorders

Stanford University

NCT00472641

COMPLETED NA 25 participants

Financial Incentives to Improve Medication Adherence

Northwell Health

NCT04191876

COMPLETED Phase 4 24 participants

Treatment With Quetiapine for Youth With Substance Use Disorders and Severe Mood Dysregulation

Boston Medical Center

NCT02845453

COMPLETED NA 23 participants

Impact of a Ketogenic Diet on Metabolic and Psychiatric Health in Patients With Bipolar or Schizophrenia Illness

Stanford University

NCT03935854

COMPLETED NA 23 participants

A Trial of SAMe for Treatment-Resistant Bipolar Depression

Mclean Hospital

NCT00762268

COMPLETED Phase 4 20 participants

Ziprasidone for the Treatment of Mania in Children and Adolescents With Bipolar Disorder

Massachusetts General Hospital

NCT00181922

COMPLETED 20 participants

Personal Adherence Evaluation of Medication Use for Adult Bipolar Disorder Patients

Case Western Reserve University

NCT00763581

COMPLETED Phase 1 20 participants

Drug-drug Interaction Study of Aripiprazole and Lamotrigine in Patients With Bipolar Type I Disorder

Otsuka Pharmaceutical Development & Commercialization

NCT00321516

COMPLETED NA 19 participants

Brain Stimulation and Cognitive Training - Efficacy

University of Michigan

NCT05111548

COMPLETED Phase 2 19 participants

Effects of Pentazocine Versus Lorazepam on Manic Symptoms

Mclean Hospital

NCT00431184

COMPLETED NA 13 participants

Treating Self Injurious Behavior: A Novel Brain Stimulation Approach

New York State Psychiatric Institute

NCT04244786

COMPLETED 10 participants

Circadian Phase in Bipolar Depression: Is it Delayed and Does it Normalize With Remission?

Northwestern University

NCT01784341

COMPLETED NA 7 participants

Early Detection and Prevention of Mood Disorders in Children of Parents With Bipolar Disorder

New York State Psychiatric Institute

NCT00338806

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Phase Distribution

PhaseTrial count
Phase 1 3
Phase 2 12
Phase 3 23
Phase 4 22

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Bipolar Disorder Trial Landscape

163 indexed Bipolar Disorder studies · 37 recruiting (23%).

Phase mix: 45 late (III/IV) vs 15 early (I/II).

Top sponsor: Massachusetts General Hospital (11 trials), 9 others listed. 13 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Bipolar Disorder?

PlainTrial tracks 163 US clinical trials for Bipolar Disorder, of which 37 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Bipolar Disorder?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.