Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Bipolar Disorder clinical trials
37 of 163 indexed Bipolar Disorder trials are currently recruiting.
163 US clinical trials · 37 currently recruiting
Bipolar Disorder is the subject of 163 registered US clinical trials on ClinicalTrials.gov, 37 of them currently open to new participants. 45 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 11 of these trials.
The research picture
Bipolar Disorder has 163 registered US clinical trials, 37 of them open to new participants right now, about 23% of the total.
- 37
- recruiting participants now
- 23%
- of trials open to enrollment
- 45
- in Phase 3–4 (later-stage)
- 11
- top sponsor: Massachusetts General Hospital
Active & Recent Trials
163 total, page 4 of 4
Geodon in Weight Loss Study for Bipolar Disorders
Stanford University
NCT00472641
Financial Incentives to Improve Medication Adherence
Northwell Health
NCT04191876
Treatment With Quetiapine for Youth With Substance Use Disorders and Severe Mood Dysregulation
Boston Medical Center
NCT02845453
Impact of a Ketogenic Diet on Metabolic and Psychiatric Health in Patients With Bipolar or Schizophrenia Illness
Stanford University
NCT03935854
A Trial of SAMe for Treatment-Resistant Bipolar Depression
Mclean Hospital
NCT00762268
Ziprasidone for the Treatment of Mania in Children and Adolescents With Bipolar Disorder
Massachusetts General Hospital
NCT00181922
Personal Adherence Evaluation of Medication Use for Adult Bipolar Disorder Patients
Case Western Reserve University
NCT00763581
Drug-drug Interaction Study of Aripiprazole and Lamotrigine in Patients With Bipolar Type I Disorder
Otsuka Pharmaceutical Development & Commercialization
NCT00321516
Brain Stimulation and Cognitive Training - Efficacy
University of Michigan
NCT05111548
Effects of Pentazocine Versus Lorazepam on Manic Symptoms
Mclean Hospital
NCT00431184
Treating Self Injurious Behavior: A Novel Brain Stimulation Approach
New York State Psychiatric Institute
NCT04244786
Circadian Phase in Bipolar Depression: Is it Delayed and Does it Normalize With Remission?
Northwestern University
NCT01784341
Early Detection and Prevention of Mood Disorders in Children of Parents With Bipolar Disorder
New York State Psychiatric Institute
NCT00338806
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 12 |
| Phase 3 | 23 |
| Phase 4 | 22 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Bipolar Disorder Trial Landscape
163 indexed Bipolar Disorder studies · 37 recruiting (23%).
Phase mix: 45 late (III/IV) vs 15 early (I/II).
Top sponsor: Massachusetts General Hospital (11 trials), 9 others listed. 13 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Bipolar Disorder?
PlainTrial tracks 163 US clinical trials for Bipolar Disorder, of which 37 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Bipolar Disorder?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.