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ClinicalTrials.gov 13 recruiting now official registry

Focal Segmental Glomerulosclerosis clinical trials

Every US clinical trial registered for Focal Segmental Glomerulosclerosis — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

20 US clinical trials · 13 currently recruiting

The research picture

Focal Segmental Glomerulosclerosis has 20 registered US clinical trials, 13 of them open to new participants right now — about 65% of the total.

13
recruiting participants now
65%
of trials open to enrollment
3
in Phase 3–4 (later-stage)
4
top sponsor: Travere Therapeutics

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING NA 375 participants

NEPTUNE Match Study

University of Michigan

NCT04571658

RECRUITING 300 participants

Recurrence Post-transplant Observational Study in Focal Segmental Glomerulosclerosis and Minimal Change Disease

University of Michigan

NCT05650619

RECRUITING Phase 3 286 participants

A Study to Find Out if BI 764198 Helps Adults and Adolescents With a Kidney Condition Called Focal Segmental Glomerulosclerosis (FSGS)

Boehringer Ingelheim

NCT07220083

RECRUITING Phase 2 84 participants

A Study to Evaluate the Efficacy and Safety of Frexalimab, Brivekimig, or Rilzabrutinib in Participants Aged 16 to 75 Years With Primary Focal Segmental Glomerulosclerosis or Minimal Change Disease

Sanofi

NCT06500702

RECRUITING Phase 2 67 participants

Study of Sparsentan Treatment in Pediatrics With Proteinuric Glomerular Diseases

Travere Therapeutics

NCT05003986

RECRUITING Phase 2 60 participants

A Study of Praliciguat in Participants With Focal Segmental Glomerulosclerosis (FSGS)

Akebia Therapeutics

NCT07268638

RECRUITING NA 35 participants

Post Approval Study for Treatment of Drug-resistant Adult and Pediatric Primary FSGS Using the LIPOSORBER® LA-15 System

Kaneka Medical America

NCT04065438

RECRUITING NA 35 participants

Post Approval Study of Liposorber LA-15 System for the Treatment of Focal Segmental Glomerulosclerosis in Children

Kaneka Medical America

NCT02235857

RECRUITING Phase 2 30 participants

An Open-Label Phase 2 Study of N-Acetyl-D-Mannosamine (ManNAc) in Subjects With Primary Focal Segmental Glomerulosclerosis

National Human Genome Research Institute (NHGRI)

NCT06664814

RECRUITING Phase 1 30 participants

AMPK-activation by Metformin in FSGS: AMP-FSGS

Yale University

NCT06090227

RECRUITING NA 30 participants

taVNS for FRNS in Children

Northwell Health

NCT05588063

RECRUITING Phase 4 20 participants

Sparsentan in Posttransplant Immunoglobulin A Nephropathy or Focal Segmental Glomerulosclerosis

Travere Therapeutics

NCT07219121

RECRUITING NA 10 participants

A Pilot Trial of taVNS for SRNS in Children (kidNEY-VNS)

Northwell Health

NCT05583942

ACTIVE NOT RECRUITING 2,050 participants

Genetic Causes of FSGS, Nephrotic Syndrome, or Kidney Failure

Beth Israel Deaconess Medical Center

NCT02194582

ACTIVE NOT RECRUITING Phase 3 371 participants

Study of Sparsentan in Patients With Primary Focal Segmental Glomerulosclerosis (FSGS)

Travere Therapeutics

NCT03493685

ACTIVE NOT RECRUITING Phase 2 103 participants

Atrasentan in Patients With Proteinuric Glomerular Diseases

Novartis Pharmaceuticals

NCT04573920

COMPLETED 487 participants

Humanistic Burden of (FSGS) Focal Segmental Glomerulosclerosis and IgAN (Immunoglobulin A Nephropathy)

Travere Therapeutics

NCT05200871

COMPLETED Phase 2 103 participants

A Phase 2 Trial of the Safety and Efficacy of Bardoxolone Methyl in Patients With Rare Chronic Kidney Diseases - PHOENIX

Biogen

NCT03366337

COMPLETED Phase 1 15 participants

Permeability Factor in Focal Segmental Glomerulosclerosis

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT00007475

COMPLETED NA 7 participants

Oral Galactose in Children With Steroid Resistant Nephrotic Syndrome

Children's National Research Institute

NCT01113385

Phase Distribution

PhaseTrial count
Phase 1 2
Phase 2 6
Phase 3 2
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Focal Segmental Glomerulosclerosis Trial Landscape

ClinicalTrials.gov lists 20 US studies indexed under Focal Segmental Glomerulosclerosis, and 13 of those are currently open to recruitment — roughly 65% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Focal Segmental Glomerulosclerosis shows 3 late-stage studies (Phase 3 and Phase 4 combined) alongside 8 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Focal Segmental Glomerulosclerosis is led by Travere Therapeutics with 4 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 20 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Focal Segmental Glomerulosclerosis?

PlainTrial tracks 20 US clinical trials for Focal Segmental Glomerulosclerosis, of which 13 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Focal Segmental Glomerulosclerosis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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