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Focal Segmental Glomerulosclerosis clinical trials
Every US clinical trial registered for Focal Segmental Glomerulosclerosis — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
20 US clinical trials · 13 currently recruiting
The research picture
Focal Segmental Glomerulosclerosis has 20 registered US clinical trials, 13 of them open to new participants right now — about 65% of the total.
- 13
- recruiting participants now
- 65%
- of trials open to enrollment
- 3
- in Phase 3–4 (later-stage)
- 4
- top sponsor: Travere Therapeutics
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
NEPTUNE Match Study
University of Michigan
NCT04571658
Recurrence Post-transplant Observational Study in Focal Segmental Glomerulosclerosis and Minimal Change Disease
University of Michigan
NCT05650619
A Study to Find Out if BI 764198 Helps Adults and Adolescents With a Kidney Condition Called Focal Segmental Glomerulosclerosis (FSGS)
Boehringer Ingelheim
NCT07220083
A Study to Evaluate the Efficacy and Safety of Frexalimab, Brivekimig, or Rilzabrutinib in Participants Aged 16 to 75 Years With Primary Focal Segmental Glomerulosclerosis or Minimal Change Disease
Sanofi
NCT06500702
Study of Sparsentan Treatment in Pediatrics With Proteinuric Glomerular Diseases
Travere Therapeutics
NCT05003986
A Study of Praliciguat in Participants With Focal Segmental Glomerulosclerosis (FSGS)
Akebia Therapeutics
NCT07268638
Post Approval Study for Treatment of Drug-resistant Adult and Pediatric Primary FSGS Using the LIPOSORBER® LA-15 System
Kaneka Medical America
NCT04065438
Post Approval Study of Liposorber LA-15 System for the Treatment of Focal Segmental Glomerulosclerosis in Children
Kaneka Medical America
NCT02235857
An Open-Label Phase 2 Study of N-Acetyl-D-Mannosamine (ManNAc) in Subjects With Primary Focal Segmental Glomerulosclerosis
National Human Genome Research Institute (NHGRI)
NCT06664814
AMPK-activation by Metformin in FSGS: AMP-FSGS
Yale University
NCT06090227
taVNS for FRNS in Children
Northwell Health
NCT05588063
Sparsentan in Posttransplant Immunoglobulin A Nephropathy or Focal Segmental Glomerulosclerosis
Travere Therapeutics
NCT07219121
A Pilot Trial of taVNS for SRNS in Children (kidNEY-VNS)
Northwell Health
NCT05583942
Genetic Causes of FSGS, Nephrotic Syndrome, or Kidney Failure
Beth Israel Deaconess Medical Center
NCT02194582
Study of Sparsentan in Patients With Primary Focal Segmental Glomerulosclerosis (FSGS)
Travere Therapeutics
NCT03493685
Atrasentan in Patients With Proteinuric Glomerular Diseases
Novartis Pharmaceuticals
NCT04573920
Humanistic Burden of (FSGS) Focal Segmental Glomerulosclerosis and IgAN (Immunoglobulin A Nephropathy)
Travere Therapeutics
NCT05200871
A Phase 2 Trial of the Safety and Efficacy of Bardoxolone Methyl in Patients With Rare Chronic Kidney Diseases - PHOENIX
Biogen
NCT03366337
Permeability Factor in Focal Segmental Glomerulosclerosis
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00007475
Oral Galactose in Children With Steroid Resistant Nephrotic Syndrome
Children's National Research Institute
NCT01113385
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
| Phase 2 | 6 |
| Phase 3 | 2 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Focal Segmental Glomerulosclerosis Trial Landscape
ClinicalTrials.gov lists 20 US studies indexed under Focal Segmental Glomerulosclerosis, and 13 of those are currently open to recruitment — roughly 65% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Focal Segmental Glomerulosclerosis shows 3 late-stage studies (Phase 3 and Phase 4 combined) alongside 8 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Focal Segmental Glomerulosclerosis is led by Travere Therapeutics with 4 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 20 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Focal Segmental Glomerulosclerosis?
PlainTrial tracks 20 US clinical trials for Focal Segmental Glomerulosclerosis, of which 13 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Focal Segmental Glomerulosclerosis?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.