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2026 data Public-data reference. official source

Graft Vs Host Disease

Open-data reference.

20 US clinical trials · 9 currently recruiting

Active & Recent Trials

RECRUITING Phase 2 190 participants

Vitamin A Supplementation in Allogeneic Stem Cell Transplantation.

Children's Hospital Medical Center, Cincinnati

NCT06450925

RECRUITING Phase 2 160 participants

Extended vs Short-term Abatacept Dosing for Graft Versus Host Disease Prophylaxis

Boston Children's Hospital

NCT04380740

RECRUITING NA 90 participants

A Feasibility Study Using CLINIMACS® for Alpha/Beta T-Cell Depletion in Stem Cell Transplant

Christopher Dvorak

NCT04337515

RECRUITING Phase 2 46 participants

A Study of Belumosudil in People at Risk of Developing Graft-Versus-Host Disease After a Stem Cell Transplant

Memorial Sloan Kettering Cancer Center

NCT07006506

RECRUITING Phase 1 41 participants

Ruxolitinib With and Without CTLA-4 Ig Abatacept for the Prophylaxis of Graft-Versus-Host Disease and Cytokine Release Syndrome After T-cell Replete Haploidentical Peripheral Blood Hematopoietic Cell Transplantation

Washington University School of Medicine

NCT06008808

RECRUITING 40 participants

Vulvovaginal Graft-versus-Host Disease: Diagnosis and Microbiome Evaluation

Case Comprehensive Cancer Center

NCT06649201

RECRUITING NA 36 participants

Impact of Exercise on the Complications of Corticosteroids in Patients With GVHD: the RESTART Trial

Dana-Farber Cancer Institute

NCT05236062

RECRUITING Phase 1 30 participants

IS-free Treg HaploHCT

Dana-Farber Cancer Institute

NCT04678401

RECRUITING Phase 1 10 participants

A Phase I-II Study of High-Dose Post-Transplant Cyclophosphamide, Bortezomib, and Abatacept for the Prevention of Graft-Versus-Host Disease (GVHD) Following Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)

Northwell Health

NCT06681922

ACTIVE NOT RECRUITING Phase 4 297 participants

Extended Treatment Protocol for Subjects Continuing to Benefit From Ibrutinib.

Pharmacyclics Switzerland

NCT03229200

ACTIVE NOT RECRUITING NA 80 participants

Multidisciplinary Intervention In Chronic GVHD

Massachusetts General Hospital

NCT04479995

ACTIVE NOT RECRUITING NA 30 participants

Patient Reported Outcomes With UVA-1 Therapy for Treatment of Sclerosing Skin Diseases

University of Utah

NCT04922736

ACTIVE NOT RECRUITING Phase 2 27 participants

Cyclophosphamide, Abatacept, and Tacrolimus for the Prevention of GvHD

NYU Langone Health

NCT05621759

ACTIVE NOT RECRUITING NA 20 participants

Horizons Chronic Graft-Versus-Host-Disease Study

University of Miami

NCT06160986

COMPLETED 100 participants

Evaluation of the Impact of Reduced Immunosuppression

Methodist Health System

NCT05238155

COMPLETED Phase 2 49 participants

RGI-2001 for the Prevention of Acute Graft-vs-Host Disease in Subjects Following Allogeneic Hematopoietic Stem Cell Transplantation

Regimmune Corporation

NCT04014790

COMPLETED Phase 1 40 participants

A Phase I/II GVHD Prevention Trial Combining Pacritinib With Sirolimus-Based Immune Suppression

H. Lee Moffitt Cancer Center and Research Institute

NCT02891603

COMPLETED Phase 2 32 participants

Safety and Efficacy Study of Adult Human Mesenchymal Stem Cells to Treat Acute Graft Versus Host Disease (GVHD)

Mesoblast

NCT00136903

COMPLETED Phase 1 26 participants

Baricitinib for the Prophylaxis of Graft-Versus-Host Disease After Peripheral Blood Hematopoietic Cell Transplantation

Washington University School of Medicine

NCT04131738

COMPLETED NA 10 participants

Topical Vitamin D in Acute Graft Versus Host Disease of the Skin

Children's Hospital Medical Center, Cincinnati

NCT03093805

Phase Distribution

PhaseTrial count
Early Phase 1 5
Phase 2 6
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Graft Vs Host Disease Trial Landscape

ClinicalTrials.gov lists 20 US studies indexed under Graft Vs Host Disease, and 9 of those are currently open to recruitment — roughly 45% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Graft Vs Host Disease shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 11 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Graft Vs Host Disease is led by Dana-Farber Cancer Institute with 2 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 20 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Graft Vs Host Disease?

PlainTrial tracks 20 US clinical trials for Graft Vs Host Disease, of which 9 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Graft Vs Host Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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