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Graft Vs Host Disease clinical trials
12 of 37 indexed Graft Vs Host Disease trials are currently recruiting.
37 US clinical trials · 12 currently recruiting
Graft Vs Host Disease is the subject of 37 registered US clinical trials on ClinicalTrials.gov, 12 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 21 in Phase 1-2 (earlier-stage). The most active sponsor is Dana-Farber Cancer Institute, running 5 of these trials.
The research picture
Graft Vs Host Disease has 37 registered US clinical trials, 12 of them open to new participants right now, about 32% of the total.
- 12
- recruiting participants now
- 32%
- of trials open to enrollment
- 1
- in Phase 3–4 (later-stage)
- 5
- top sponsor: Dana-Farber Cancer Institute
Active & Recent Trials
37 total, page 1 of 1
Long-term Evaluation and Follow-up Care of Patients Treated With Stem Cell Transplants
National Heart, Lung, and Blood Institute (NHLBI)
NCT00106925
Pediatric cGVHD Symptom Scale
National Cancer Institute (NCI)
NCT04044365
Vitamin A Supplementation in Allogeneic Stem Cell Transplantation.
Children's Hospital Medical Center, Cincinnati
NCT06450925
Extended vs Short-term Abatacept Dosing for Graft Versus Host Disease Prophylaxis
Boston Children's Hospital
NCT04380740
A Feasibility Study Using CLINIMACS® for Alpha/Beta T-Cell Depletion in Stem Cell Transplant
Christopher Dvorak
NCT04337515
Phase I/II Study of Pacritinib, A JAK2/IRAK1/CSF1R Inhibitor, in Refractory Chronic Graft-Versus-Host Disease (cGVHD) After Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)
National Cancer Institute (NCI)
NCT05531786
A Study of Belumosudil in People at Risk of Developing Graft-Versus-Host Disease After a Stem Cell Transplant
Memorial Sloan Kettering Cancer Center
NCT07006506
Ruxolitinib With and Without CTLA-4 Ig Abatacept for the Prophylaxis of Graft-Versus-Host Disease and Cytokine Release Syndrome After T-cell Replete Haploidentical Peripheral Blood Hematopoietic Cell Transplantation
Washington University School of Medicine
NCT06008808
Vulvovaginal Graft-versus-Host Disease: Diagnosis and Microbiome Evaluation
Case Comprehensive Cancer Center
NCT06649201
Impact of Exercise on the Complications of Corticosteroids in Patients With GVHD: the RESTART Trial
Dana-Farber Cancer Institute
NCT05236062
IS-free Treg HaploHCT
Dana-Farber Cancer Institute
NCT04678401
A Phase I-II Study of High-Dose Post-Transplant Cyclophosphamide, Bortezomib, and Abatacept for the Prevention of Graft-Versus-Host Disease (GVHD) Following Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)
Northwell Health
NCT06681922
Chronic GVHD Response Measures Validation
Fred Hutchinson Cancer Center
NCT01902576
Extended Treatment Protocol for Subjects Continuing to Benefit From Ibrutinib.
Pharmacyclics Switzerland
NCT03229200
Multidisciplinary Intervention In Chronic GVHD
Massachusetts General Hospital
NCT04479995
Nonmyeloablative Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease and Beta-thalassemia in People With Higher Risk of Transplant Failure
National Heart, Lung, and Blood Institute (NHLBI)
NCT02105766
Patient Reported Outcomes With UVA-1 Therapy for Treatment of Sclerosing Skin Diseases
University of Utah
NCT04922736
Cyclophosphamide, Abatacept, and Tacrolimus for the Prevention of GvHD
NYU Langone Health
NCT05621759
Horizons Chronic Graft-Versus-Host-Disease Study
University of Miami
NCT06160986
Immune Mediated Disorders After Allogeneic Hematopoietic Cell Transplantation
Fred Hutchinson Cancer Center
NCT01206309
Obinutuzumab in cGVHD After Allogeneic Peripheral Blood Stem Cell Transplantation
Dana-Farber Cancer Institute
NCT02867384
Treatment for Acute Graft-Versus-Host Disease (BMT CTN 0302)
National Heart, Lung, and Blood Institute (NHLBI)
NCT00224874
The Role of Cyclosporine in Blood Cell Transplants With T-Cell Add-Back for Blood Cancers
National Heart, Lung, and Blood Institute (NHLBI)
NCT00001873
Evaluation of the Impact of Reduced Immunosuppression
Methodist Health System
NCT05238155
Evaluation of Immunoregulatory Cells in Hematopoietic Stem Cell Transplant
Vanderbilt University
NCT00179049
Tacrolimus, Sirolimus and Ustekinumab vs. Tacrolimus and Sirolimus for the Prevention of Acute Graft-Versus-Host Disease
H. Lee Moffitt Cancer Center and Research Institute
NCT01713400
RGI-2001 for the Prevention of Acute Graft-vs-Host Disease in Subjects Following Allogeneic Hematopoietic Stem Cell Transplantation
Regimmune Corporation
NCT04014790
A Phase I/II GVHD Prevention Trial Combining Pacritinib With Sirolimus-Based Immune Suppression
H. Lee Moffitt Cancer Center and Research Institute
NCT02891603
A Pilot Study of Alpha-1-Antitrypsin (AAT) in Steroid Refractory Acute Graft vs Host Disease
University of Michigan Rogel Cancer Center
NCT01700036
Comparison of Gut Microbiota, Inflammation and Symptoms Following Allogeneic HSCT
University of Florida
NCT02398708
Research Study of Visilizumab for Treatment of Acute Graft Versus Host Disease
Facet Biotech
NCT00032292
Safety and Efficacy Study of Adult Human Mesenchymal Stem Cells to Treat Acute Graft Versus Host Disease (GVHD)
Mesoblast
NCT00136903
Rituximab Therapy for Steroid-Refractory Chronic Graft Versus Host Disease
Dana-Farber Cancer Institute
NCT00136396
Baricitinib for the Prophylaxis of Graft-Versus-Host Disease After Peripheral Blood Hematopoietic Cell Transplantation
Washington University School of Medicine
NCT04131738
Vorinostat Plus Tacrolimus & Methotrexate to Prevent Graft vs Host Disease Following Unrelated Stem Cell Transplant
University of Michigan Rogel Cancer Center
NCT01790568
Impact of Adnexal Involvement of the Severity and Prognosis of Chronic Graft-versus-Host Disease
Dana-Farber Cancer Institute
NCT01221766
Topical Vitamin D in Acute Graft Versus Host Disease of the Skin
Children's Hospital Medical Center, Cincinnati
NCT03093805
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 8 |
| Phase 2 | 13 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Graft Vs Host Disease Trial Landscape
37 indexed Graft Vs Host Disease studies · 12 recruiting (32%).
Phase mix: 1 late (III/IV) vs 21 early (I/II).
Top sponsor: Dana-Farber Cancer Institute (5 trials), 9 others listed. 37 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Graft Vs Host Disease?
PlainTrial tracks 37 US clinical trials for Graft Vs Host Disease, of which 12 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Graft Vs Host Disease?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.