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ClinicalTrials.gov 18 recruiting now official registry

B-cell Lymphoma clinical trials

18 of 39 indexed B-cell Lymphoma trials are currently recruiting.

39 US clinical trials · 18 currently recruiting

B-cell Lymphoma is the subject of 39 registered US clinical trials on ClinicalTrials.gov, 18 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 37 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 3 of these trials.

The research picture

B-cell Lymphoma has 39 registered US clinical trials, 18 of them open to new participants right now, about 46% of the total.

18
recruiting participants now
46%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
3
top sponsor: M.D. Anderson Cancer Center
Phase 125Phase 212Phase 32

Active & Recent Trials

39 total, page 1 of 1

RECRUITING Phase 3 300 participants

A Study to Investigate the Efficacy and Safety of Sonrotoclax Plus Zanubrutinib Compared With Placebo Plus Zanubrutinib in Adults With Relapsed/Refractory Mantle Cell Lymphoma (CELESTIAL-RRMCL)

BeOne Medicines

NCT06742996

RECRUITING Phase 1 290 participants

A Safety and Efficacy Study Evaluating CTX131 in Adult Subjects With Relapsed/Refractory Hematologic Malignancies

CRISPR Therapeutics

NCT06492304

RECRUITING Phase 1 140 participants

IKS03 in Patients With Advanced B Cell Non-Hodgkin Lymphomas

Iksuda Therapeutics

NCT05365659

RECRUITING Phase 1 126 participants

CD19/CD22 Bicistronic Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults With Recurrent or Refractory CD19/CD22-expressing B Cell Malignancies

National Cancer Institute (NCI)

NCT05442515

RECRUITING Phase 1 120 participants

A Safety and Efficacy Study Evaluating CTX112 in Subjects With Relapsed or Refractory B-Cell Malignancies

CRISPR Therapeutics

NCT05643742

RECRUITING Phase 1 80 participants

A Study to Investigate Safety and Effectiveness of BGB-16673 in Combination With Other Agents in Participants With Relapsed or Refractory B-Cell Malignancies

BeOne Medicines

NCT06634589

RECRUITING Phase 1 80 participants

Phase I/II Study of CAR.70- Engineered IL15-transduced Cord Blood-derived NK Cells in Conjunction With Lymphodepleting Chemotherapy for the Management of Relapse/Refractory Hematological Malignances

M.D. Anderson Cancer Center

NCT05092451

RECRUITING Phase 1 72 participants

CRISPR-Edited Allogeneic Anti-CD19 CAR-T Cell Therapy for Relapsed/Refractory B Cell Non-Hodgkin Lymphoma (ANTLER)

Caribou Biosciences

NCT04637763

RECRUITING Phase 2 52 participants

Mosunetuzumab With Lenalidomide Augmentation as First-line Therapy for Follicular and Marginal Zone Lymphoma

Brown University

NCT04792502

RECRUITING Phase 2 43 participants

Rituximab and Zanubrutinib in Patients With Indolent B-cell Lymphomas

H. Lee Moffitt Cancer Center and Research Institute

NCT06350318

RECRUITING Phase 1 42 participants

ACE1831 in Adult Subjects With Relapsed/ Refractory CD20-expressing B-cell Malignancies

Acepodia Biotech

NCT05653271

RECRUITING Phase 2 40 participants

A Study of Axicabtagene Ciloleucel and Glofitamab as Second-Line Therapy for Relapsed or Refractory Patients With Large B Cell Lymphoma

M.D. Anderson Cancer Center

NCT06213311

RECRUITING Phase 2 36 participants

A Phase II Trial of Mosunetuzumab, Polatuzumab, Tafasitamab, and Lenalidomide in Patients With Relapsed B-cell NHL

M.D. Anderson Cancer Center

NCT05615636

RECRUITING Phase 2 30 participants

Local Manufacture of CAR T-Cell Products for the Treatment of B-Cell Lymphoma and B-Acute Lymphoblastic Leukemia

John Lister

NCT05281809

RECRUITING Phase 2 24 participants

A Phase II Study of the Combination of Pembrolizumab and ATRA Combination Treatment of Relapsed HL and B-NHL

Rita Assi

NCT06484920

RECRUITING Phase 1 18 participants

SynKIR-310 for Relapsed/Refractory B-NHL

Verismo Therapeutics

NCT06544265

RECRUITING Phase 1 15 participants

A Feasibility Trial of Tazemetostat Plus CAR T Cell Therapy in B-cell Lymphomas

Weill Medical College of Cornell University

NCT05934838

RECRUITING Phase 1 15 participants

Mosunetuzumab Consolidation Therapy After autoSCT in r/r Aggressive B Cell Lymphoma

Washington University School of Medicine

NCT05412290

ACTIVE NOT RECRUITING Phase 1 316 participants

Study of Oral LOXO-338 in Patients With Advanced Blood Cancers

Eli Lilly and Company

NCT05024045

ACTIVE NOT RECRUITING Phase 2 62 participants

A Study of Anakinra to Prevent or Treat Severe Side Effects for Patients Receiving CAR-T Cell Therapy

Memorial Sloan Kettering Cancer Center

NCT04148430

ACTIVE NOT RECRUITING Phase 2 51 participants

Pembrolizumab in Combination With Chemotherapy for Patients With Untreated B Cell Lymphoma

University of Chicago

NCT03995147

ACTIVE NOT RECRUITING Phase 2 39 participants

Phase II Palbociclib +Ibrutinib in Mantle Cell Lymphoma

Alliance Foundation Trials

NCT03478514

ACTIVE NOT RECRUITING Phase 1 30 participants

Study of 19(T2)28z1xx TRAC-Chimeric Antigen Receptor (CAR) T Cells in People With B-Cell Lymphoma

Memorial Sloan Kettering Cancer Center

NCT05757700

ACTIVE NOT RECRUITING Phase 1 23 participants

Venetoclax Plus Inotuzumab for B-ALL

Dana-Farber Cancer Institute

NCT05016947

ACTIVE NOT RECRUITING Phase 1 14 participants

CD19 Chimeric Receptor Expressing T Lymphocytes In B-Cell Non Hodgkin's Lymphoma, ALL & CLL

Baylor College of Medicine

NCT00586391

ACTIVE NOT RECRUITING Phase 1 11 participants

Loncastuximab Tesirine in Combination With DA-EPOCH-R in Patients With Previously Untreated Aggressive B-cell Lymphoid Malignancies

Medical College of Wisconsin

NCT05270057

ACTIVE NOT RECRUITING Phase 1 10 participants

CD22-CAR T Cells in Children and Young Adults With B Cell Malignancies

Stanford University

NCT04088864

COMPLETED Phase 3 848 participants

Treatment of Mature B-cell Lymphoma/Leukaemia

Gustave Roussy, Cancer Campus, Grand Paris

NCT00162656

COMPLETED Phase 1 111 participants

A Study of Glofitamab in Combination With Rituximab or Obinutuzumab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (CHOP), or Polatuzumab Vedotin Plus Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone (CHP) in Participants With Non-Hodgkin Lymphomas or With DLBCL

Hoffmann-La Roche

NCT03467373

COMPLETED Phase 1 66 participants

Study of the Safety and Tolerability of PCI-32765 in Patients With Recurrent B Cell Lymphoma

Pharmacyclics

NCT00849654

COMPLETED Phase 2 66 participants

VELCADE® (Bortezomib) With Rituximab in Subjects With Relapsed or Refractory Indolent B-Cell Lymphoma

Millennium Pharmaceuticals

NCT00085696

COMPLETED Phase 2 63 participants

Study of the Bruton's Tyrosine Kinase Inhibitor in Subjects With Relapsed/Refractory Marginal Zone Lymphoma

Pharmacyclics

NCT01980628

COMPLETED Phase 1 46 participants

Study of an Investigational Drug, ASP3026, in Patients With Advanced Malignancies (Solid Tumors and B-Cell Lymphoma)

Astellas Pharma

NCT01284192

COMPLETED Phase 1 39 participants

Study of the Efficacy and Safety of Ublituximab in Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma

TG Therapeutics

NCT01647971

COMPLETED Phase 1 35 participants

A Phase 1 Study of SB1518 for the Treatment of Advanced Lymphoid Malignancies

S*BIO

NCT00741871

COMPLETED Phase 1 26 participants

BR101801 in Adult Patients With Advanced Hematologic Malignancies(Phase I)

Boryung Pharmaceutical Co.

NCT04018248

COMPLETED Phase 2 22 participants

Total Body Irradiation +/- Total Lymphoid Irradiation & Anti-Thymocyte Globulin in Non-myeloablative Hematopoietic Cell Transplantation

Stanford University

NCT03734601

COMPLETED Phase 1 16 participants

Dose Escalation Study of Clofarabine in Patients With Relapsed or Refractory Low Grade or Intermediate-Grade B-Cell Lymphoma

Yale University

NCT00338494

COMPLETED Phase 1 11 participants

Venetoclax With Obinutuzumab and Magrolimab (VENOM) in Relapsed and Refractory Indolent B-cell Malignancies

National Cancer Institute (NCI)

NCT04599634

Phase Distribution

PhaseTrial count
Phase 1 25
Phase 2 12
Phase 3 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the B-cell Lymphoma Trial Landscape

39 indexed B-cell Lymphoma studies · 18 recruiting (46%).

Phase mix: 2 late (III/IV) vs 37 early (I/II).

Top sponsor: M.D. Anderson Cancer Center (3 trials), 9 others listed. 39 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for B-cell Lymphoma?

PlainTrial tracks 39 US clinical trials for B-cell Lymphoma, of which 18 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for B-cell Lymphoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.