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NCT05270057 · ClinicalTrials.gov registry record · Phase 1
Loncastuximab Tesirine in Combination With DA-EPOCH-R in Patients With Previously Untreated Aggressive B-cell Lymphoid Malignancies
A Phase 1 study of B-cell Lymphoma and Burkitt Lymphoma, sponsored by Medical College of Wisconsin.
- Active
- Registry status
- Phase 1
- Development phase
- 11
- Enrollment target
- 3
- Study locations
NCT05270057 is a Phase 1 study of B-cell Lymphoma and Burkitt Lymphoma that is active but no longer recruiting, run by Medical College of Wisconsin. The registered enrollment target is 11 participants, below the 90-participant average among 38 other B-cell Lymphoma trials with a reported enrollment target (88% lower). The trial reports 3 study locations across 2 states.
The verdict
NCT05270057, a Phase 1 study of B-cell Lymphoma and Burkitt Lymphoma, is active but no longer recruiting, sponsored by Medical College of Wisconsin.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 11 participants
- Enrollment target
- 3
- Study locations
Study Summary
The overarching hypothesis for this study is that a safe and tolerable dose (i.e., the maximum tolerated dose) will be identified for loncastuximab tesirine in combination with dose-adjusted etoposide phosphate, prednisone, vincristine sulfate (Oncovin), cyclophosphamide, doxorubicin hydrochloride (hydroxydaunorubicin), and rituximab (DA-EPOCH-R) for patients with previously untreated aggressive B-cell lymphoid malignancies.
Conditions Studied
Interventions
- DRUG Cyclophosphamide
- DRUG Doxorubicin
- DRUG Rituximab
- DRUG Etoposide
- DRUG Vincristine
Study Locations (3)
Wisconsin
- University of Wisconsin School of Medicine and Public Health - Madison
- Froedtert Hospital & the Medical College of Wisconsin - Milwaukee
Texas
- University of Texas Southwestern - Dallas
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 11 participants |
| Start Date | 2023-01-26 |
| Est. Completion | 2027-10-11 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05270057
The ClinicalTrials.gov registry entry for NCT05270057 describes a study currently listed as active not recruiting, categorized as Phase 1. The registered enrollment target is 11 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 90-participant average among 38 other B-cell Lymphoma trials with a reported enrollment target (88% lower). The listed sponsor is Medical College of Wisconsin, which has 447 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with B-cell Lymphoma appearing as the primary indexed condition, and to 5 interventions - of which Cyclophosphamide is the first listed.
NCT05270057 reports 3 study locations spanning 2 distinct geographic areas - top geographies include Wisconsin, Texas.
Frequently Asked Questions
What is clinical trial NCT05270057 about?
NCT05270057 is a clinical study titled "Loncastuximab Tesirine in Combination With DA-EPOCH-R in Patients With Previously Untreated Aggressive B-cell Lymphoid Malignancies". The overarching hypothesis for this study is that a safe and tolerable dose (i.e., the maximum tolerated dose) will be identified for loncastuximab tesirine in combination with dose-adjusted etoposide phosphate, prednisone, vincristine sulfate (Oncovin), cyclophosphamide, doxorubicin hydrochloride (...
What is the current status of trial NCT05270057?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 11 participants. The study started on 2023-01-26. Estimated completion is 2027-10-11.
What conditions does trial NCT05270057 study?
This clinical trial studies the following conditions: B-cell Lymphoma, Burkitt Lymphoma.
What interventions are being tested in trial NCT05270057?
The interventions under investigation include: Cyclophosphamide (DRUG), Doxorubicin (DRUG), Rituximab (DRUG), Etoposide (DRUG), Vincristine (DRUG).
Who is sponsoring clinical trial NCT05270057?
This trial is sponsored by Medical College of Wisconsin, which has 447 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05270057 being conducted?
This trial has 3 study locations across Texas, Wisconsin. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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