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NCT04148430 · ClinicalTrials.gov registry record · Phase 2
A Study of Anakinra to Prevent or Treat Severe Side Effects for Patients Receiving CAR-T Cell Therapy
A Phase 2 study of B-cell Lymphoma and B-Cell Non-Hodgkin Lymphoma, sponsored by Memorial Sloan Kettering Cancer Center.
- Active
- Registry status
- Phase 2
- Development phase
- 62
- Enrollment target
- 2
- Study locations
NCT04148430: Active Phase 2 study of B-cell Lymphoma and B-Cell Non-Hodgkin Lymphoma, sponsored by Memorial Sloan Kettering Cancer Center.
NCT04148430 is a Phase 2 study of B-cell Lymphoma and B-Cell Non-Hodgkin Lymphoma that is active but no longer recruiting, run by Memorial Sloan Kettering Cancer Center. The registered enrollment target is 62 participants, below the 89-participant average among 38 other B-cell Lymphoma trials with a reported enrollment target (30% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04148430, a Phase 2 study of B-cell Lymphoma and B-Cell Non-Hodgkin Lymphoma, is active but no longer recruiting, sponsored by Memorial Sloan Kettering Cancer Center.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 2
- Development phase
- 62 participants
- Enrollment target
- 2
- Study locations
Study Summary
This study is being done to see if the investigational drug, anakinra, prevent or reverse the severe side effects caused by CAR-T cell therapy.
Primary Outcome
Determine the rate of severe neurotoxicities, \>/= Grade 3 or any grade seizure, within the first 4 weeks of treatment with prophylactic use of anakinra in participants receiving CD19-specific CAR T cells
Conditions Studied
Interventions
- DRUG Anakinra
Study Locations (2)
New Jersey
- Hackensack Meridian Health (Data collection only) - Hackensack
New York
- Memorial Sloan Kettering Cancer Center - New York
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 62 participants |
| Start Date | 2019-10-30 |
| Est. Completion | 2026-10 |
| Phase | Phase 2 |
What the registry record for NCT04148430 still lists
NCT04148430 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 62 participants, a relatively small participant target, below the 89-participant average among 38 other B-cell Lymphoma trials with a reported enrollment target (30% lower).
The record links to 3 conditions, with B-cell Lymphoma appearing as the primary indexed condition, and to 1 intervention - of which Anakinra is the first listed.
NCT04148430 reports a single indexed study location in New Jersey, New York.
Frequently Asked Questions
What is clinical trial NCT04148430 about?
NCT04148430 is a clinical study titled "A Study of Anakinra to Prevent or Treat Severe Side Effects for Patients Receiving CAR-T Cell Therapy". This study is being done to see if the investigational drug, anakinra, prevent or reverse the severe side effects caused by CAR-T cell therapy.
What is the current status of trial NCT04148430?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 62 participants. The study started on 2019-10-30. Estimated completion is 2026-10.
What conditions does trial NCT04148430 study?
This clinical trial studies the following conditions: B-cell Lymphoma, B-Cell Non-Hodgkin Lymphoma, B-Cell ALL.
What interventions are being tested in trial NCT04148430?
The interventions under investigation include: Anakinra (DRUG).
Who is sponsoring clinical trial NCT04148430?
This trial is sponsored by Memorial Sloan Kettering Cancer Center, which has 1,884 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04148430 being conducted?
This trial has 2 study locations across New Jersey, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for B-cell Lymphoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04148430's enrollment target sits among peer trials
62 15th of 38 higher than 24 of 38 other B-cell Lymphoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other B-cell Lymphoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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