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NCT04637763 · ClinicalTrials.gov registry record · Phase 1
CRISPR-Edited Allogeneic Anti-CD19 CAR-T Cell Therapy for Relapsed/Refractory B Cell Non-Hodgkin Lymphoma (ANTLER)
A Phase 1 study of Lymphoma and Non-Hodgkin Lymphoma, sponsored by Caribou Biosciences.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 72
- Enrollment target
- 20
- Study locations
NCT04637763: Recruiting Phase 1 study of Lymphoma and Non-Hodgkin Lymphoma, sponsored by Caribou Biosciences.
NCT04637763 is a Phase 1 study of Lymphoma and Non-Hodgkin Lymphoma that is actively recruiting participants, run by Caribou Biosciences. The registered enrollment target is 72 participants, below the 483-participant average among 299 other Lymphoma trials with a reported enrollment target (85% lower). The trial reports 20 study locations across 12 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04637763, a Phase 1 study of Lymphoma and Non-Hodgkin Lymphoma, is actively recruiting participants, sponsored by Caribou Biosciences.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 72 participants
- Enrollment target
- 20
- Study locations
Study Summary
CB010A is a study evaluating safety, emerging efficacy, pharmacokinetics and immunogenicity of CB-010 in adults with relapsed/refractory B cell non-Hodgkin lymphoma after lymphodepletion consisting of cyclophosphamide and fludarabine.
Conditions Studied
Interventions
- DRUG Cyclophosphamide
- DRUG Fludarabine
- GENETIC CB-010
Study Locations (20)
Arizona
- Banner MD Anderson Cancer Center - Gilbert
- HonorHealth - Scottsdale
- University of Arizona Cancer Center - Tucson
California
- University of California San Diego Moores Cancer Center - La Jolla
- University of Southern California, Norris Comprehensive Cancer Center - Los Angeles
- Chao Family Comprehensive Cancer Center/University of California Irvine - Orange
Georgia
- Bone and Marrow Transplant Group of Georgia - Atlanta
- Georgia Cancer Center at Augusta University - Augusta
Kentucky
- University of Kentucky Markey Cancer - Lexington
- Norton Cancer Institute - Louisville
New Jersey
- Hackensack Medical Center - Hackensack
- Atlantic Health System - Morristown
New York
- Nyu Langone Health - New York
- Montefiore Medical Center - The Bronx
Alabama
- University of Alabama at Birmingham - Birmingham
Arkansas
- University of Arkansas - Little Rock
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 72 participants |
| Start Date | 2021-05-26 |
| Est. Completion | 2025-09 |
| Phase | Phase 1 |
What NCT04637763 shows while recruiting
NCT04637763 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 72 participants, a relatively small participant target, below the 483-participant average among 299 other Lymphoma trials with a reported enrollment target (85% lower).
The record links to 7 conditions, with Lymphoma appearing as the primary indexed condition, and to 3 interventions - of which Cyclophosphamide is the first listed.
NCT04637763 names 20 study sites across 12 states, led by Arizona, California, Georgia.
Frequently Asked Questions
What is clinical trial NCT04637763 about?
NCT04637763 is a clinical study titled "CRISPR-Edited Allogeneic Anti-CD19 CAR-T Cell Therapy for Relapsed/Refractory B Cell Non-Hodgkin Lymphoma (ANTLER)". CB010A is a study evaluating safety, emerging efficacy, pharmacokinetics and immunogenicity of CB-010 in adults with relapsed/refractory B cell non-Hodgkin lymphoma after lymphodepletion consisting of cyclophosphamide and fludarabine.
What is the current status of trial NCT04637763?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 72 participants. The study started on 2021-05-26. Estimated completion is 2025-09.
What conditions does trial NCT04637763 study?
This clinical trial studies the following conditions: Lymphoma, Non-Hodgkin Lymphoma, Lymphoma, Non-Hodgkin, B-cell Lymphoma, Relapsed Non-Hodgkin Lymphoma.
What interventions are being tested in trial NCT04637763?
The interventions under investigation include: Cyclophosphamide (DRUG), Fludarabine (DRUG), CB-010 (GENETIC).
Who is sponsoring clinical trial NCT04637763?
This trial is sponsored by Caribou Biosciences, which has 3 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04637763 being conducted?
This trial has 20 study locations across Alabama, Arizona, Arkansas, California, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Where NCT04637763's enrollment target sits among peer trials
72 116th of 299 higher than 184 of 299 other Lymphoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Lymphoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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