Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 1

A Study to Investigate Safety and Effectiveness of BGB-16673 in Combination With Other Agents in Participants With Relapsed or Refractory B-Cell Malignancies

NCT06634589 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to measure the safety, preliminary antitumor activity, pharmacokinetics, and pharmacodynamics with BGB-16673 in combination with other agents in participants with relapsed or refractory (R/R) B-cell malignancies. This study is structured as a master protocol with separate substudies. This study currently includes four substudies, and more substudies may be added as other combination agents are identified.

Interventions

  • DRUG Zanubrutinib
  • DRUG BGB-16673
  • DRUG Sonrotoclax
  • DRUG Mosunetuzumab
  • DRUG Glofitamab

Study Locations (20)

New York

  • Icahn School of Medicine At Mount Sinai — New York
  • Columbia University Medical Center — New York
  • Weill Cornell Medical College Newyork Presbyterian Hospital — New York
  • Memorial Sloan Kettering Cancer Center Mskcc — New York
  • University of Rochester — Rochester

Florida

  • Mayo Clinic Jacksonville — Jacksonville
  • Moffitt Cancer Center — Tampa

Wisconsin

  • University of Wisconsin — Madison
  • Medical College of Wisconsin — Milwaukee

Arizona

  • Mayo Clinic Phoenix — Phoenix

California

  • University of Southern Californianorris Comprehensive — Los Angeles

Kansas

  • The University of Kansas Cancer Center — Westwood

Minnesota

  • Mayo Clinic Rochester — Rochester

Missouri

  • Washington University School of Medicine — St Louis

Trial Details

FieldValue
Enrollment Target 80 participants
Start Date 2024-11-27
Est. Completion 2029-12-02
Phase Phase 1

Sponsor

BeOne Medicines

138 total trials

Interested in This Trial?

Always speak with your doctor before enrolling in a clinical trial.

Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06634589

The ClinicalTrials.gov registry entry for NCT06634589 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 80 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is BeOne Medicines, which has 138 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 4 conditions, with Refractory Cancer appearing as the primary indexed condition, and to 5 interventions — of which Zanubrutinib is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06634589 reports 20 study locations spanning 14 distinct geographic areas — top geographies include New York, Florida, Wisconsin. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06634589 about?

NCT06634589 is a clinical study titled "A Study to Investigate Safety and Effectiveness of BGB-16673 in Combination With Other Agents in Participants With Relapsed or Refractory B-Cell Malignancies". The purpose of this study is to measure the safety, preliminary antitumor activity, pharmacokinetics, and pharmacodynamics with BGB-16673 in combination with other agents in participants with relapsed or refractory (R/R) B-cell malignancies. This study is structured as a master protocol with separat...

What is the current status of trial NCT06634589?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 80 participants. The study started on 2024-11-27. Estimated completion is 2029-12-02.

What conditions does trial NCT06634589 study?

This clinical trial studies the following conditions: Refractory Cancer, B-cell Lymphoma, Relapsed Cancer, B-cell Malignancy. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06634589?

The interventions under investigation include: Zanubrutinib (DRUG), BGB-16673 (DRUG), Sonrotoclax (DRUG), Mosunetuzumab (DRUG), Glofitamab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06634589?

This trial is sponsored by BeOne Medicines, which has 138 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06634589 being conducted?

This trial has 20 study locations across Arizona, California, Florida, Kansas, Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial