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Autonomic Failure: early-phase trial registry
10 of 12 indexed Autonomic Failure trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #1,429 of 28,707 conditions by registered trial count.
12 US clinical trials · 10 currently recruiting · #1,429 of 28,707 conditions by registered trial count
Autonomic Failure: 12 US clinical trials tracked, 10 recruiting.
Autonomic Failure is the subject of 12 registered US clinical trials on ClinicalTrials.gov, 10 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 5 in Phase 1-2 (earlier-stage). The most active sponsor is Vanderbilt University Medical Center, running 9 of these trials.
Enrollment posture brief
Registry condition autonomic-failure
OPEN 10 | RECR 83% | LATE 0 | EARLY 5 | RANK #1429 | SPON 9
Volume-matched condition peers
Nearest open-share peer: Alcoholic Hepatitis (83% recruiting · 6 trials)
Autonomic Failure lists 10 open slots (83% of 12 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Autonomic Failure on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Autonomic Failure is recruiting above its size-band peers.
10 of 12 indexed trials (83.3%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Autonomic Failure research.
Vanderbilt University Medical Center accounts for 9 of 12 trials (75%). 4 distinct sponsors appear on at least one study for this condition label.
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Most Autonomic Failure trials plan to enrol fewer than 100 people.
Median target enrolment is 31 among the 12 trials that report a genuine target (sentinel values excluded). 12 of those (100%) plan for fewer than 100 participants.
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Autonomic Failure research is mostly interventional.
11 interventional and 1 observational studies make up this index (91.7% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
12 total, page 1 of 1
CPAP for the Treatment of Supine Hypertension
Vanderbilt University Medical Center
NCT05489575
Effect of Raised Head of the Bed on Lying Blood Pressure in Autonomic Failure
Vanderbilt University Medical Center
NCT04502225
[18F]F-DOPA Imaging in Patients With Autonomic Failure
Daniel Claassen
NCT04246437
Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure
Vanderbilt University Medical Center
NCT02897063
Effect of Midodrine vs Abdominal Compression on Cardiovascular Risk Markers in Autonomic Failure Patients
Vanderbilt University Medical Center
NCT04620382
Automated Abdominal Binder for Orthostatic Hypotension
Vanderbilt University Medical Center
NCT03482297
Use of Accelerometer for Quantification of Neurogenic Orthostatic Hypotension Symptoms
Vanderbilt University Medical Center
NCT04782830
Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failure
Vanderbilt University Medical Center
NCT02429557
Overnight Trials With Heat Stress in Autonomic Failure Patients With Supine Hypertension
Vanderbilt University Medical Center
NCT03042988
Treatment of Supine Hypertension in Autonomic Failure (CPAP)
Vanderbilt University Medical Center
NCT03312556
Clinical Laboratory Evaluation of Chronic Autonomic Failure
National Institute of Neurological Disorders and Stroke (NINDS)
NCT03648905
Abdominal Compression in Orthostatic Hypotension
Mayo Clinic
NCT01223391
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 5 |
Top Sponsors
Named interventions
Most-linked intervention names on Autonomic Failure records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Autonomic Failure trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Autonomic Failure page
12 registered trials, 10 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 10 Autonomic Failure trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Vanderbilt University Medical Center sponsors the most Autonomic Failure trials on record, review their full trial history before evaluating a specific study. See Vanderbilt University Medical Center's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Autonomic Failure condition card totals 12 registered trials; most-linked intervention Midodrine; top US site state Tennessee. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.