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ClinicalTrials.gov 112 recruiting now official registry

Autism Spectrum Disorder clinical trials

112 of 225 indexed Autism Spectrum Disorder trials are currently recruiting.

225 US clinical trials · 112 currently recruiting

Autism Spectrum Disorder is the subject of 225 registered US clinical trials on ClinicalTrials.gov, 112 of them currently open to new participants. 4 are in Phase 3-4 (later-stage) and 49 in Phase 1-2 (earlier-stage). The most active sponsor is Stanford University, running 19 of these trials.

The research picture

Autism Spectrum Disorder has 225 registered US clinical trials, 112 of them open to new participants right now, about 50% of the total.

112
recruiting participants now
50%
of trials open to enrollment
4
in Phase 3–4 (later-stage)
19
top sponsor: Stanford University
Phase 112Phase 237Phase 32Phase 42

Active & Recent Trials

225 total, page 3 of 5

RECRUITING 21 participants

Impact of Sulphonylureas on Neurodevelopmental Outcomes in KCNJ11-related Intermediate Developmental Delay, Epilepsy and Neonatal Diabetes (iDEND) Syndrome

Royal Devon and Exeter NHS Foundation Trust

NCT05751525

RECRUITING NA 20 participants

Effects of Multiple-Session Transcranial Direct Current Stimulation (tDCS) on Behavioral, Physiological, and Electrophysiological Measures With Adults With Autism Spectrum Disorder (ASD)

University of New Mexi

NCT06495684

RECRUITING NA 20 participants

Speech Treatment for Minimally Verbal Children With ASD and CAS

MGH Institute of Health Professions

NCT05066178

RECRUITING Phase 2 20 participants

A Phase 2A Trial of MM402 for Autism Spectrum Disorder

Definium Therapeutics US

NCT07303907

RECRUITING 19 participants

Characterization of Dysmorphology in Subjects With Creatine Transporter Deficiency

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NCT05600946

RECRUITING NA 15 participants

Novel Adaptive Cognitive Training in Autistic Adults with Co-occurring Insomnia

University of South Florida

NCT06291298

RECRUITING NA 12 participants

Abnormal Connectivity Involving the Social Reciprocity Network in Autism and the Impact of Neurostimulation in Mitigating the Abnormalities

Christiana Care Health Services

NCT06807684

RECRUITING NA 10 participants

Behavior Analytic Support of Needle-related Hospital Visits for Autistic Patients

Boston Medical Center

NCT06712784

RECRUITING NA 10 participants

taVNS for Anxiety in ASD

Medical University of South Carolina

NCT06258590

RECRUITING NA 10 participants

Telehealth Intervention for Autism Spectrum Disorder

Thomas Jefferson University

NCT04832152

RECRUITING 10 participants

DDX3X Syndrome -The Seaver Autism Center for Research and Treatment is Characterizing DDX3X-related Neurodevelopmental Disorders Using Genetic, Medical, and Neuropsychological Measures.

Icahn School of Medicine at Mount Sinai

NCT03718910

RECRUITING NA 8 participants

Milieu Teaching-AV (MT-AV Pilot)

Vanderbilt University Medical Center

NCT06794476

ACTIVE NOT RECRUITING NA 700 participants

Evaluating a Social and Communication Intervention for Preschoolers

Hugo W. Moser Research Institute at Kennedy Krieger

NCT01591707

ACTIVE NOT RECRUITING 600 participants

Genome Environment Microbiome and Metabolome in Autism Study

Massachusetts General Hospital

NCT04271774

ACTIVE NOT RECRUITING 500 participants

Autism ALERT Expansion

Oregon Health and Science University

NCT06246890

ACTIVE NOT RECRUITING NA 360 participants

Trial of Autism Parent Navigator Program

Penn State University

NCT04744428

ACTIVE NOT RECRUITING NA 358 participants

AIRB-4: Self-Determined Learning Model of Instruction

Health Resources and Services Administration (HRSA)

NCT04972851

ACTIVE NOT RECRUITING NA 320 participants

Efficacy of the ASPEN Intervention Program in Low-Resource Communities

University of Texas at Austin

NCT04505488

ACTIVE NOT RECRUITING NA 308 participants

AIR-B4: Mind the Gap

Health Resources and Services Administration (HRSA)

NCT04972825

ACTIVE NOT RECRUITING 297 participants

Mitochondrial Dysfunction in Autism Spectrum Disorder

University of Arkansas

NCT02000284

ACTIVE NOT RECRUITING NA 264 participants

AIR-B4: Remaking Recess (RR)

Health Resources and Services Administration (HRSA)

NCT04972838

ACTIVE NOT RECRUITING 240 participants

Genetic Contributions to Autism Spectrum Disorders

Boston Children's Hospital

NCT01160783

ACTIVE NOT RECRUITING 205 participants

Mapping the Genotype, Phenotype, and Natural History of Phelan-McDermid Syndrome

Boston Children's Hospital

NCT02461420

ACTIVE NOT RECRUITING 201 participants

A Novel Framework for Impaired Imitation in ASD

Hugo W. Moser Research Institute at Kennedy Krieger

NCT03423160

ACTIVE NOT RECRUITING NA 200 participants

Project AFECT (Autism Family Empowerment Coaching and Training Program)

Stanford University

NCT05910502

ACTIVE NOT RECRUITING Phase 2 150 participants

ML-004 in Adolescents and Adults With Autism Spectrum Disorders (ASD)

MapLight Therapeutics

NCT05081245

ACTIVE NOT RECRUITING NA 144 participants

DOD Regulating Together Intervention

Children's Hospital Medical Center, Cincinnati

NCT05803369

ACTIVE NOT RECRUITING NA 140 participants

PRISM Intervention Study

University of California, Los Angeles

NCT03883139

ACTIVE NOT RECRUITING NA 100 participants

Transcranial Magnetic Stimulation on Neural and Behavioral Facets of Social Cognition in Autism Spectrum Disorder

Yale University

NCT04242355

ACTIVE NOT RECRUITING NA 100 participants

RCT to Evaluate Social Skills in Children With Autism Using VR Technology (SoCaVR)

Floreo

NCT06453629

ACTIVE NOT RECRUITING Phase 2 86 participants

CASCADE: CAnnabidiol Study in Children With Autism Spectrum DisordEr

University of Colorado, Denver

NCT04520685

ACTIVE NOT RECRUITING NA 80 participants

Evaluating the Impact of Telehealth-Based ASD Assessments and Supports on Child and Caregiver Outcomes

University of California, Davis

NCT04881656

ACTIVE NOT RECRUITING NA 80 participants

Treatment to Improve Sleep in Caregivers With Insomnia and a Child With Autism

University of Pennsylvania

NCT05373537

ACTIVE NOT RECRUITING NA 75 participants

Assessing the Gut Microbiome and Its Association With Pediatric Stress and Cognition

Nova Southeastern University

NCT06269614

ACTIVE NOT RECRUITING NA 75 participants

A Center Based Study of Pivotal Response Treatment for Preschoolers With Autism

Stanford University

NCT03778827

ACTIVE NOT RECRUITING NA 73 participants

Facing Your Fears: Adolescents With ASD and Intellectual Disability

University of Colorado, Denver

NCT05131425

ACTIVE NOT RECRUITING NA 65 participants

Behavior Therapy for Irritability in Autism

Yale University

NCT04654260

ACTIVE NOT RECRUITING NA 64 participants

Intervention-Induced Plasticity of Flexibility and Learning Mechanisms in ASD

Children's National Research Institute

NCT05131659

ACTIVE NOT RECRUITING Phase 2 60 participants

Microbiota Transplant Therapy for Children With Both Autism Spectrum Disorder and Gastrointestinal Disorders

Gut-Brain-Axis Therapeutics

NCT06503978

ACTIVE NOT RECRUITING NA 56 participants

Developing a Culturally Adapted Intervention for Latino Youth Transitioning to Adulthood

The University of Texas Health Science Center, Houston

NCT06107972

ACTIVE NOT RECRUITING NA 56 participants

Boosting Language Outcomes of Minimally Verbal Children With ASD (BLOOM)

University of California, Los Angeles

NCT04218331

ACTIVE NOT RECRUITING Phase 2 56 participants

Leucovorin for the Treatment of Language Impairment in Children With Autism Spectrum Disorder

Southwest Autism Research & Resource Center

NCT02839915

ACTIVE NOT RECRUITING NA 55 participants

Testing a Family Service Navigator Program for Low-resourced Families of Young Children with Autism Spectrum Disorder

Vanderbilt University

NCT05099705

ACTIVE NOT RECRUITING Phase 2 55 participants

Microbiota Transfer Therapy for Adults With Autism Spectrum Disorder (ASD) Who Have Gastrointestinal Disorders

Arizona State University

NCT03408886

ACTIVE NOT RECRUITING Phase 2 50 participants

MTT for Children With ASD Who Have Gastrointestinal Disorders

Arizona State University

NCT04182633

ACTIVE NOT RECRUITING Phase 2 48 participants

Sulforaphane in a New Jersey (NJ) Population of Individuals With Autism

Rutgers, The State University of New Jersey

NCT02677051

ACTIVE NOT RECRUITING Phase 2 42 participants

Trial of Cannabidiol to Treat Severe Behavior Problems in Children With Autism

University of California, San Diego

NCT04517799

ACTIVE NOT RECRUITING Phase 2 40 participants

Pilot Trial of Pregnenolone in Autism

Stanford University

NCT02627508

ACTIVE NOT RECRUITING NA 30 participants

Melatonin and Sleep Spindles in Autism

Massachusetts General Hospital

NCT05716906

ACTIVE NOT RECRUITING NA 24 participants

Theta Burst Stimulation for Refractory Depression in Autism Spectrum Disorder

Children's Hospital Medical Center, Cincinnati

NCT06670040

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Phase Distribution

PhaseTrial count
Phase 1 12
Phase 2 37
Phase 3 2
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Autism Spectrum Disorder Trial Landscape

225 indexed Autism Spectrum Disorder studies · 112 recruiting (50%).

Phase mix: 4 late (III/IV) vs 49 early (I/II).

Top sponsor: Stanford University (19 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Autism Spectrum Disorder?

PlainTrial tracks 225 US clinical trials for Autism Spectrum Disorder, of which 112 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Autism Spectrum Disorder?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.