Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05131659 · ClinicalTrials.gov registry record · NA
Intervention-Induced Plasticity of Flexibility and Learning Mechanisms in ASD
A NA study of Autism Spectrum Disorder and Adolescent Behavior, sponsored by Children's National Research Institute.
- Active
- Registry status
- NA
- Development phase
- 64
- Enrollment target
- 2
- Study locations
NCT05131659 is a NA study of Autism Spectrum Disorder and Adolescent Behavior that is active but no longer recruiting, run by Children's National Research Institute. The registered enrollment target is 64 participants, below the 135-participant average among 224 other Autism Spectrum Disorder trials with a reported enrollment target (53% lower). The trial reports 2 study locations across 1 state.
The verdict
NCT05131659, a NA study of Autism Spectrum Disorder and Adolescent Behavior, is active but no longer recruiting, sponsored by Children's National Research Institute.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 64 participants
- Enrollment target
- 2
- Study locations
Study Summary
This project explores the association between learning and cognitive flexibility by testing whether a cognitive behavioral intervention designed to improve flexibility in ASD changes learning and associated neural activation using model-based functional magnetic resonance imaging (m-fMRI). The study proposes that variability in learning mechanisms is associated with behavioral flexibility and explains differences in adaptive and treatment outcomes. The study employs a longitudinal case-controlled design in 60 14-18 year old youth with ASD at 3 time-points 8 months apart, each including m-fMRI during learning and behavioral measurement of executive and adaptive function. Aim 1 tests the hypothesis that individual variation in learning biases and their neural correlates predicts behavioral flexibility and is stable over time. Aim 2 tests plasticity of learning mechanisms induced by a cognitive-behavioral intervention for flexibility. Aim 3 tests hypothesis about intervention-induced plasticity of neural functional connectivity.
Conditions Studied
Interventions
- BEHAVIORAL Executive function group therapy
Study Locations (2)
District of Columbia
- Children's National Hospital - Washington D.C.
- Georgetown University - Washington D.C.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 64 participants |
| Start Date | 2021-10-20 |
| Est. Completion | 2026-05-31 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05131659
The ClinicalTrials.gov registry entry for NCT05131659 describes a study currently listed as active not recruiting, categorized as NA. The registered enrollment target is 64 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 135-participant average among 224 other Autism Spectrum Disorder trials with a reported enrollment target (53% lower). The listed sponsor is Children's National Research Institute, which has 92 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Autism Spectrum Disorder appearing as the primary indexed condition, and to 1 intervention - of which Executive function group therapy is the first listed.
NCT05131659 reports 2 study locations spanning 1 distinct geographic area - top geographies include District of Columbia.
Frequently Asked Questions
What is clinical trial NCT05131659 about?
NCT05131659 is a clinical study titled "Intervention-Induced Plasticity of Flexibility and Learning Mechanisms in ASD". This project explores the association between learning and cognitive flexibility by testing whether a cognitive behavioral intervention designed to improve flexibility in ASD changes learning and associated neural activation using model-based functional magnetic resonance imaging (m-fMRI). The study...
What is the current status of trial NCT05131659?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 64 participants. The study started on 2021-10-20. Estimated completion is 2026-05-31.
What conditions does trial NCT05131659 study?
This clinical trial studies the following conditions: Autism Spectrum Disorder, Adolescent Behavior, Executive Dysfunction.
What interventions are being tested in trial NCT05131659?
The interventions under investigation include: Executive function group therapy (BEHAVIORAL).
Who is sponsoring clinical trial NCT05131659?
This trial is sponsored by Children's National Research Institute, which has 92 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05131659 being conducted?
This trial has 2 study locations across District of Columbia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Autism Spectrum Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
-
COMPASS Across Settings (CAST) for Improving Transition Outcomes for Students With ASD
RECRUITING · NA
-
Emergent Multi-Class Imitation Training
RECRUITING · NA
-
Physical Activity and Community EmPOWERment Project
RECRUITING · NA
-
Online Pivotal Response Treatment Training in Autism Spectrum Disorder
RECRUITING · NA
-
Cerebellum and Autism: Regional Specialization for Social and Executive Functions
RECRUITING · NA
-
Milieu Teaching-AV (MT-AV Pilot)
RECRUITING · NA
Explore more on PlainTrial
Autism Spectrum Disorder
All registered trials for this condition
Adolescent Behavior
All registered trials for this condition
District of Columbia
All trials with a study site in District of Columbia
Recruiting now
Find trials open to new participants near you
Rankings
Top sponsors, conditions, and phases
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.