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Anterior Cruciate Ligament Reconstruction clinical trials
Every US clinical trial registered for Anterior Cruciate Ligament Reconstruction — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
12 US clinical trials · 7 currently recruiting
The research picture
Anterior Cruciate Ligament Reconstruction has 12 registered US clinical trials, 7 of them open to new participants right now — about 58% of the total.
- 7
- recruiting participants now
- 58%
- of trials open to enrollment
- 4
- in Phase 3–4 (later-stage)
- 2
- top sponsor: Hospital for Special Surgery, New York
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Brain-Computer Interface Visualization Training to Optimize Muscle Activation Following Orthopaedic Surgery
Rush University Medical Center
NCT07020312
Anterior Femoral and Adductor Canal Nerve Blocks in Peds Knees
Hospital for Special Surgery, New York
NCT06590402
The Effects of Tranexamic Acid on Joint Inflammation and Cartilage Health in Anterior Cruciate Ligament Injured Patients
Stanford University
NCT03552705
Assessment of Gait Adaptation Due to an Asymmetric Walking Protocol
University of Connecticut
NCT05968729
Mental Imagery to Improve Quadriceps Strength Post Anterior Cruciate Ligament Reconstruction: a Feasibility Study
Marquette University
NCT06858293
Immunometabolic Mechanisms of Blood Flow Restriction (BFR) Training After Anterior Cruciate Ligament Reconstruction
Yale University
NCT05012982
Anterior Cruciate Ligament (ACL) Reconstruction With Autologous Fat Pad Derived Mesenchymal Stem Cells
The Methodist Hospital Research Institute
NCT06798623
STABILITY 2: Anterior Cruciate Ligament Reconstruction +/- Lateral Tenodesis With Patellar vs Quad Tendon
University of Pittsburgh
NCT03935750
Pediatric ACL: Understanding Treatment Options
Boston Children's Hospital
NCT02772770
Safety of OMS103HP in Patients Undergoing Anterior Cruciate Ligament (ACL) Reconstruction
Omeros Corporation
NCT00245271
Comparing Subsartorial Saphenous Nerve Blocks With and Without Dexamethasone for Anterior Cruciate Ligament Reconstruction
Hospital for Special Surgery, New York
NCT01586806
Anterior Cruciate Ligament Pain Study
Emory University
NCT02604550
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 2 |
| Phase 3 | 1 |
| Phase 4 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Anterior Cruciate Ligament Reconstruction Trial Landscape
ClinicalTrials.gov lists 12 US studies indexed under Anterior Cruciate Ligament Reconstruction, and 7 of those are currently open to recruitment — roughly 58% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Anterior Cruciate Ligament Reconstruction shows 4 late-stage studies (Phase 3 and Phase 4 combined) alongside 3 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Anterior Cruciate Ligament Reconstruction is led by Hospital for Special Surgery, New York with 2 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 12 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Anterior Cruciate Ligament Reconstruction?
PlainTrial tracks 12 US clinical trials for Anterior Cruciate Ligament Reconstruction, of which 7 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Anterior Cruciate Ligament Reconstruction?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.