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NCT03552705 · ClinicalTrials.gov registry record · Phase 2
The Effects of Tranexamic Acid on Joint Inflammation and Cartilage Health in Anterior Cruciate Ligament Injured Patients
A Phase 2 study of Anterior Cruciate Ligament Reconstruction, sponsored by Stanford University.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 50
- Enrollment target
- 1
- Study location
NCT03552705: Recruiting Phase 2 study of Anterior Cruciate Ligament Reconstruction, sponsored by Stanford University.
NCT03552705 is a Phase 2 study of Anterior Cruciate Ligament Reconstruction that is actively recruiting participants, run by Stanford University. The registered enrollment target is 50 participants, below the 290-participant average among 11 other Anterior Cruciate Ligament Reconstruction trials with a reported enrollment target (83% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03552705, a Phase 2 study of Anterior Cruciate Ligament Reconstruction, is actively recruiting participants, sponsored by Stanford University.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 50 participants
- Enrollment target
- 1
- Study location
Study Summary
Patients who tear their ACL are at high risk for developing arthritis (post-traumatic osteoarthritis-PTOA) just 10 years later. Joint bleeding and inflammation contribute to deterioration of joint health. This study will determine whether treatment with Tranexamic Acid (TXA), an FDA approved medication that reduces bleeding right after ACL injury and reconstructive surgery reduces inflammation and improves joint health as a new strategy to prevent or delay the onset of PTOA.
Primary Outcome
To determine whether TXA administered acutely after ACL injury reduces synovial fluid markers of inflammation and cartilage degradation
Conditions Studied
Interventions
- DRUG Tranexamic Acid
- DRUG Placebos
Study Locations (1)
California
- Stanford University - Stanford
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2019-08-01 |
| Est. Completion | 2027-01-14 |
| Phase | Phase 2 |
What NCT03552705 shows while recruiting
NCT03552705 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 290-participant average among 11 other Anterior Cruciate Ligament Reconstruction trials with a reported enrollment target (83% lower).
The record links to 1 condition, with Anterior Cruciate Ligament Reconstruction appearing as the primary indexed condition, and to 2 interventions - of which Tranexamic Acid is the first listed.
NCT03552705 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT03552705 about?
NCT03552705 is a clinical study titled "The Effects of Tranexamic Acid on Joint Inflammation and Cartilage Health in Anterior Cruciate Ligament Injured Patients". Patients who tear their ACL are at high risk for developing arthritis (post-traumatic osteoarthritis-PTOA) just 10 years later. Joint bleeding and inflammation contribute to deterioration of joint health. This study will determine whether treatment with Tranexamic Acid (TXA), an FDA approved medicat...
What is the current status of trial NCT03552705?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 50 participants. The study started on 2019-08-01. Estimated completion is 2027-01-14.
What conditions does trial NCT03552705 study?
This clinical trial studies the following conditions: Anterior Cruciate Ligament Reconstruction.
What interventions are being tested in trial NCT03552705?
The interventions under investigation include: Tranexamic Acid (DRUG), Placebos (DRUG).
Who is sponsoring clinical trial NCT03552705?
This trial is sponsored by Stanford University, which has 1,744 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03552705 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT03552705's enrollment target sits among peer trials
50 8th of 11 higher than 4 of 11 other Anterior Cruciate Ligament Reconstruction trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Anterior Cruciate Ligament Reconstruction trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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