Yale University

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, Yale University sits in the top decile of US sponsors by registered trial count (#13 of 15,742 sponsors by registered trial count).

1,492 total trials 254 currently recruiting 1005 completed early-phase tilt top decile by trial count

Yale University: 1,492 sponsored US clinical trials, 254 recruiting.

Yale University sponsors 1,492 registered US clinical trials on ClinicalTrials.gov, 254 of them currently recruiting, and 1,005 completed. 99 of these trials are in Phase 3-4 (later-stage) and 579 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Opioid Use Disorder, with 19 trials.

Top-decile sponsor footprint

Yale University ranks in the top decile of sponsors by registered trial count (#13 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

D 60/100

1,005 of 1,138 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (88.3%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

1,492 total, page 29 of 30

COMPLETED Phase 2

Therapeutic Substance Abuse Treatment in Pregnancy - 1

NCT00227903

COMPLETED Phase 1

Effect of Progesterone on Smoking Behavior in Male and Female Smokers

NCT00271206

COMPLETED Phase 2

Brief Introductory Therapy for Opioid Dependence

NCT00406484

TERMINATED NA

The Effects of GABA Enhancing Medications on Individuals Addicted to Cocaine - 3

NCT00142883

COMPLETED NA

Stage I Randomized Trial of Mentalization-Based Therapy for Substance Using Mothers of Infants and Toddlers

NCT00319436

COMPLETED Phase 2

Usefulness of Selegiline as an Aid to Quit Smoking - 1

NCT00129311

COMPLETED NA

Wait and See Antibiotic Prescription for Acute Otitis Media: A Randomized Controlled Trial

NCT00250900

COMPLETED NA

Directly Observed Therapy for Community-Released HIV+ Prisoners

NCT00786396

COMPLETED Phase 2

Clinical Trial of Abstinence-Linked Money Management

NCT00536900

COMPLETED Phase 2

Treatment With Mecamylamine in Smoking and Non-smoking Alcohol Dependent Patients

NCT00342563

COMPLETED Phase 4

Metabolic Effect of Metformin in Obese Insulin Resistant Adolescents With Normal Glucose Tolerance

NCT00667498

COMPLETED NA

RUPP PI PDD: Drug and Behavioral Therapy for Children With Pervasive Developmental Disorders

NCT00080145

COMPLETED Phase 2

Aripiprazole Treatment of Prodromal Patients

NCT00237874

COMPLETED Phase 2

Efficacy of Pimozide Augmentation for Clozapine Partial Response

NCT00374244

COMPLETED Phase 3

Motivational Enhancement for Spanish Speaking Individuals - 1

NCT00078169

COMPLETED NA

Prospective Cohort of Opiate Dependent Patients on Buprenorphine/Naloxone for Maintenance

NCT00622596

COMPLETED NA

Clinical Efficacy of Disulfiram in LAAM-Maintained Cocaine Abusers

NCT00580827

COMPLETED Phase 2

Increasing Treatment Adherence in Co-Occurring Psychiatric and Drug Use Disorders

NCT00237822

COMPLETED NA

Impact of Diet and/or Exercise-induced Weight Loss on Cardiovascular Risk Factors

NCT00588978

COMPLETED

Enhancing the Prospective Prediction of Psychosis

NCT00291200

COMPLETED NA

Social Skills in Children With Autism Spectrum Disorders

NCT02147236

COMPLETED Phase 2

Facilitation of NMDA Receptor Function in Patients With Schizophrenia and Co-morbid Alcoholism

NCT00338598

COMPLETED Phase 1

Long-term Nutritional Intervention Study to Determine How Protein Affects Calcium Metabolism

NCT00671944

COMPLETED Phase 4

Hepatitis B Vaccination Through Syringe Exchange Programs: A Randomized, Controlled Trial of Vaccination Schedules

NCT01259453

COMPLETED Phase 2

HIV Risk Reduction and Drug Abuse Treatment in Malaysia

NCT00383045

COMPLETED Phase 2

Drug Therapy for Alcohol Dependence in Alaska Natives (Naltrexone/Sertraline)

NCT00000451

COMPLETED Phase 2

Nicotinic Receptor Augmentation of SSRI Antidepressants

NCT00319319

COMPLETED Phase 1

Nicotinic Modulation of Schizophrenia-like Information Processing Deficits in Healthy Subjects

NCT00690170

COMPLETED Phase 3

D-Serine Treatment of Negative Symptoms and Cognitive Deficits in Schizophrenia

NCT00237809

COMPLETED NA

Genetic Counseling for Menopausal Therapy Decision-Making for Women at Increased Risk for Breast Cancer

NCT00349011

COMPLETED Phase 4

Combination Nicotine Replacement for Alcoholic Smokers

NCT00064844

COMPLETED NA

Transcranial Magnetic Stimulation (TMS) Treatment for Patients With Persistent Auditory Hallucinations

NCT00042159

COMPLETED NA

Treatment for Obesity and Binge Eating Disorder

NCT00537758

COMPLETED NA

Emergency Physician Brief Interventions for Alcohol

NCT00443183

COMPLETED NA

Effects of a Comprehensive Weight Management Program on Obese Adolescents and Children

NCT00409422

COMPLETED NA

Treatment of Refractory Schizophrenia With Riluzole

NCT00375050

COMPLETED NA

Environmental Treatment for Seasonal Affective Disorder (SAD)

NCT00139997

COMPLETED

C-reactive Protein and Endothelial Dysfunction in Women With Glucose Intolerance

NCT00589355

COMPLETED

Gender Differences in Prevalence of Undiagnosed Diabetes in ACS

NCT00589459

COMPLETED Phase 3

Naltrexone & SSRI in Alcoholics With Depression/PTSD

NCT00338962

COMPLETED Phase 1

Antidepressant Treatment for Premenstrual Syndrome and Premenstrual Dysphoric Disorder

NCT00048854

COMPLETED

Study to Investigate the Pathophysiology of Type 2 Diabetes in Youth

NCT00536250

COMPLETED

Investigation Into the Effects Upon Brain Response to Change in Circulating Glucose Levels in Diabetes Mellitus

NCT00580710

COMPLETED NA

Anger Control Training for Youth With Tourette Syndrome

NCT00486551

COMPLETED NA

Directly Observed Antiretroviral Therapy Among Active Drug Users

NCT00367172

COMPLETED Phase 3

Motivational Enhancement to Improve Treatment Engagement and Outcome in Subjects Seeking Treatment for Substance Abuse - 1

NCT00032981

COMPLETED Phase 3

Group Prenatal Care for Reducing the Risk of STDs in Pregnant Young Women

NCT00271960

COMPLETED Phase 3

Motivational Interviewing to Improve Treatment Engagement and Outcome in Subjects Seeking Treatment for Substance Abuse - 1

NCT00032994

COMPLETED NA

Ketamine/Placebo Family History Positive Study

NCT00588952

COMPLETED NA

Intravenous Alcohol Administration Using BrAc Method in Healthy Subjects With and Without a Family History of Alcoholism

NCT00612352

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Phase Distribution

PhaseTrial count
Phase 1 312
Phase 2 267
Phase 3 52
Phase 4 47

What is open in the Yale University pipeline

254 recruiting of 1,492 indexed (17% open); 1,005 completed (67%).

Phase mix: 99 late (III/IV) vs 579 early (I/II) (early-phase heavy).

Top condition: Opioid Use Disorder (19 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

Yale University: open-pipeline peers nationwide

Peers matched on 1,492 registered trials and 17% open enrollment, not the therapeutic-area sidebar.

Yale University sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 05001,0001,5002,000 5%10%15%20% Total trials Recruiting share Yale UniversityWashington University School of MedicineJohns Hopkins UniversityUniversity of PennsylvaniaNovartis PharmaceuticalsNYU Langone HealthCSL BehringPenn State UniversityUniversity of Hawaii
Yale University sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

Yale University sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 1,492 trials (± recruiting share)

Sponsors near 17% open enrollment (± trial volume)

What to do with this Yale University page

1,492 registered trials is a research-attention snapshot, not an endorsement of Yale University or any single study.

  • 254 of Yale University's trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Opioid Use Disorder is the condition Yale University studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Opioid Use Disorder trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. Yale University pipeline card: 1,492 registered trials from official public datasets. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.