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NCT00536250 · ClinicalTrials.gov registry record
Study to Investigate the Pathophysiology of Type 2 Diabetes in Youth
A clinical trial, sponsored by Yale University.
- Completed
- Registry status
- 255
- Enrollment target
NCT00536250: Completed study, sponsored by Yale University.
NCT00536250 is a clinical trial that has completed, run by Yale University. The registered enrollment target is 255 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00536250 has completed, sponsored by Yale University.
- COMPLETED
- Registry status
- 255 participants
- Enrollment target
Study Summary
The purpose of the study is to determine the role of beta-cell function and insulin resistance in the development of impaired glucose tolerance (IGT) and type 2 diabetes in children and adolescents who have an increased risk of developing type 2 diabetes due to overweight/obesity or a family history of overweight/obesity, diabetes and/or impaired fasting glucose. It is hypothesized that: 1)Obese adolescents with IGT will be more insulin resistant than obese adolescents with NGT. Insulin resistance will be the best predictor of changes in glucose tolerance status., 2)Beta cell function will be impaired in obese adolescents with IGT compared to obese adolescents with NGT., 3)Obese adolescents with IGT will present with greater intramyocellular, intrahepatic and visceral fat than obese adolescents with NGT. Furthermore, obese adolescents with IGT will have larger adipocytes, while having significantly fewer adipocytes compared to obese adolescents with NGT. Obese adolescents with IGT will also have altered expression of key genes related to insulin resistance., and 4)Abnormalities in endothelial function as manifested by low FMD and PAT are already present in obese adolescents with IGT and are linked to insulin resistance.
Primary Outcome
glucose tolerance status as determined by oral glucose tolerance test - fasting and 2 hour glucoses
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 255 participants |
| Start Date | 2001-09 |
| Est. Completion | 2017-03 |
What the finished NCT00536250 record still lists
NCT00536250 is an observational study that tracks outcomes without assigning an intervention. The registered 255 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 0 interventions.
NCT00536250 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00536250 about?
NCT00536250 is a clinical study titled "Study to Investigate the Pathophysiology of Type 2 Diabetes in Youth". The purpose of the study is to determine the role of beta-cell function and insulin resistance in the development of impaired glucose tolerance (IGT) and type 2 diabetes in children and adolescents who have an increased risk of developing type 2 diabetes due to overweight/obesity or a family history...
What is the current status of trial NCT00536250?
This trial is currently completed. The enrollment target is 255 participants. The study started on 2001-09. Estimated completion is 2017-03.
Who is sponsoring clinical trial NCT00536250?
This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.
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