Yale University

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, Yale University sits in the top decile of US sponsors by registered trial count (#13 of 15,742 sponsors by registered trial count).

1,492 total trials 254 currently recruiting 1005 completed early-phase tilt top decile by trial count

Yale University: 1,492 sponsored US clinical trials, 254 recruiting.

Yale University sponsors 1,492 registered US clinical trials on ClinicalTrials.gov, 254 of them currently recruiting, and 1,005 completed. 99 of these trials are in Phase 3-4 (later-stage) and 579 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Opioid Use Disorder, with 19 trials.

Top-decile sponsor footprint

Yale University ranks in the top decile of sponsors by registered trial count (#13 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

D 60/100

1,005 of 1,138 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (88.3%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

1,492 total, page 13 of 30

COMPLETED Phase 2

Periarticular Injection Versus Peripheral Nerve Block in Total Hip Arthroplasty

NCT03977454

COMPLETED Phase 2

Guanfacine to Improve Substance Use Outcomes in Women

NCT03980184

COMPLETED NA

Pragmatic RCT of SBIRT-PM

NCT04062214

COMPLETED NA

A Virtual Reality Videogame for E-cigarette Prevention in Teens

NCT04054765

COMPLETED NA

Neurobiological Responses in Alcoholism and Early Trauma

NCT04128228

COMPLETED NA

The Evaluation of a School Climate Videogame Intervention

NCT04025294

COMPLETED Phase 1

THC and Ketamine Effects in Humans: Relation to Neural Oscillations and Psychosis

NCT04199468

COMPLETED Phase 1

Neuroimmune Effects of Opioid Administration

NCT03801629

COMPLETED NA

Voiding Assessment Based on Minimum Spontaneous Void of 150 mL Compared to Retrograde Fill Method After Female Pelvic Floor Reconstructive Surgery

NCT03539107

COMPLETED Phase 2

Cognitive-Behavioral and Pharmacologic (LDX) Treatment of Binge-Eating Disorder and Obesity: Medication Change for Non-Responders

NCT03946111

COMPLETED Phase 3

Cognitive-Behavioral and Pharmacologic (LDX) Treatment of Binge-Eating Disorder and Obesity: Maintenance Treatment

NCT03926052

COMPLETED NA

CBT4CBT With Spanish Alcohol Users

NCT03474588

TERMINATED Phase 1

Dronabinol for Pain and Inflammation in Adults Living With Sickle Cell Disease

NCT03978156

COMPLETED NA

Text Messaging in Patients on Adjuvant Endocrine Therapy for Breast Cancer

NCT03949270

TERMINATED Phase 2

Ketamine for Severe Adolescent Depression: Intermediate-term Safety and Efficacy

NCT03889756

COMPLETED NA

Daytime Bright Light, Circadian Abnormalities, and Delirium in Medical ICU Patients

NCT03684460

COMPLETED Phase 1

Effect of Allopregnanolone on Stress-induced Craving

NCT04015869

COMPLETED Early Phase 1

Cognitive Function and Pain Threshold in People Who Are Methadone Maintained

NCT04027166

TERMINATED NA

Impact of Cigarette and E-cigarette Flavors on Adult Smoking Behavior

NCT04009850

TERMINATED

Hepatitis C Positive Organ to Recipient Hepatitis C Negative Longitudinal Transplant Study

NCT04057001

COMPLETED

Families Coping Together With Alzheimer's Disease

NCT04642885

COMPLETED Early Phase 1

Measuring the Neuroimmune Response to Alcohol

NCT04251221

COMPLETED Phase 1

Ivabradine for Rate Control in Permanent Atrial Fibrillation

NCT03987204

COMPLETED

Patient Reported Outcomes for Opioid Use Disorder

NCT03985163

COMPLETED Phase 1

The Effect of Glucagon on Rates of Hepatic Mitochondrial Oxidation in Man Assessed by PINTA

NCT03965130

COMPLETED NA

Application of Electrical Impedance Myography (EIM) as a Potential Biomarker of Idiopathic Inflammatory Myopathies

NCT03918356

COMPLETED NA

Evaluating the Feasibility and Efficacy of a Real-time Smoking Intervention Using Wearable Technology

NCT04172623

COMPLETED Phase 1

Effects of E-Cigarette Flavors on Adults TCORS 2.0

NCT03635333

COMPLETED Phase 2

Endotracheal Tubes to Prevent Ventilator-Associated Pneumonia

NCT03705286

COMPLETED Phase 1

Open-label Trial of Tofacitinib in Cutaneous Sarcoidosis and Granuloma Annulare

NCT03910543

TERMINATED NA

Brief ROC Training Effects on Alcohol Drinking

NCT03928626

COMPLETED NA

Intervention to Reduce Diaper Need and Increase Use of Pediatric Preventive Care

NCT03490045

COMPLETED NA

Peer Online Motivational Interviewing for Sexual and Gender Minority Male Survivors

NCT03794986

TERMINATED Phase 1

Effects of Psilocybin in Concussion Headache

NCT03806985

TERMINATED Early Phase 1

Vitamin D and Cocaine Administration

NCT04826133

COMPLETED Phase 3

Cognitive-Behavioral and Pharmacologic (LDX) Treatment of Binge-Eating Disorder and Obesity: Acute Treatment

NCT03924193

COMPLETED Early Phase 1

The Role of Neuroactive Steroids in Stress, Drug Craving and Drug Use in Cocaine Use Disorders

NCT03953612

COMPLETED Early Phase 1

Nicotine Delivery Rate and Its Abuse Potential: Impact of Menthol

NCT03580525

COMPLETED NA

Opioid and Pain Cognition

NCT04132609

COMPLETED NA

Implementation and Dissemination of an Evidence-Based Tobacco Product Use Prevention Videogame Intervention With Adolescents

NCT03815591

COMPLETED NA

Stress Reduction Study for Partners of Early Stage Dementia

NCT03691428

COMPLETED

Creation of a Digital Heart Failure Registry Using a Novel Mobile Health Platform: HUGO-HF

NCT03810638

COMPLETED Early Phase 1

Mechanism and Effects of Manipulating Chloride Homeostasis in Stable Heart Failure

NCT03440970

COMPLETED NA

Pilot of Pragmatic SBIRT Study

NCT03307967

COMPLETED NA

Yale Wellness Project

NCT03229577

COMPLETED Phase 2

Fatty Acid Amide Hydrolase (FAAH) Inhibitor Treatment of Cannabis Use Disorder (CUD)

NCT03386487

COMPLETED NA

Inpatient Versus Outpatient Foley Cervical Ripening Study

NCT03725397

COMPLETED NA

Imaging Synaptic Density in Cocaine and Opiate Addiction In Vivo Using 11UCB-J PET

NCT03527485

TERMINATED NA

Effect of Adiposity on Hepatic and Peripheral Insulin Resistance in Type 1 Diabetes

NCT03582956

COMPLETED NA

Evaluation and Management of Metabolic Bone Disease in Kidney Transplant Recipients

NCT03958409

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Phase Distribution

PhaseTrial count
Phase 1 312
Phase 2 267
Phase 3 52
Phase 4 47

What is open in the Yale University pipeline

254 recruiting of 1,492 indexed (17% open); 1,005 completed (67%).

Phase mix: 99 late (III/IV) vs 579 early (I/II) (early-phase heavy).

Top condition: Opioid Use Disorder (19 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

Yale University: open-pipeline peers nationwide

Peers matched on 1,492 registered trials and 17% open enrollment, not the therapeutic-area sidebar.

Yale University sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 05001,0001,5002,000 5%10%15%20% Total trials Recruiting share Yale UniversityWashington University School of MedicineJohns Hopkins UniversityUniversity of PennsylvaniaNovartis PharmaceuticalsNYU Langone HealthCSL BehringPenn State UniversityUniversity of Hawaii
Yale University sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

Yale University sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 1,492 trials (± recruiting share)

Sponsors near 17% open enrollment (± trial volume)

What to do with this Yale University page

1,492 registered trials is a research-attention snapshot, not an endorsement of Yale University or any single study.

  • 254 of Yale University's trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Opioid Use Disorder is the condition Yale University studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Opioid Use Disorder trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. Yale University pipeline card: 1,492 registered trials from official public datasets. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.