National Institute on Drug Abuse (NIDA)

335 total trials 14 currently recruiting 292 completed

National Institute on Drug Abuse (NIDA) sponsors 335 registered US clinical trials on ClinicalTrials.gov, 14 of them currently recruiting, and 292 completed. 30 of these trials are in Phase 3-4 (later-stage) and 202 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Cocaine-Related Disorders, with 17 trials.

Trial Pipeline

335 total, page 6 of 7

COMPLETED Phase 2

Methylphenidate in the Treatment of Cocaine Dependent Patients With Adult Attention Deficit Hyperactivity Disorder - 5

NCT00015223

COMPLETED Phase 2

Buprenorphine Detoxification - BBDVI - 19

NCT00000237

COMPLETED Phase 1

Stress Hormones and Human Cocaine Use - 7

NCT00000290

COMPLETED Phase 2

Tyrosine for Methamphetamine Dependence - 1

NCT00000322

COMPLETED Phase 4

Modeling Impaired Judgement in Cocaine Abusers - 6

NCT00015236

COMPLETED Phase 2

The Efficacy of Methadyl Acetate (LAAM) and Contingency Management Procedures for Treating Dual Opioid and Cocaine Abuse - 1

NCT00158288

COMPLETED Phase 2

Tryptophan and Behavior Therapy for Cocaine Abuse - 1

NCT00000324

COMPLETED Phase 2

Flupenthixol and Haloperidol for Treating Cocaine Abuse Schizophrenics - 9

NCT00000274

COMPLETED Phase 2

Phase II Double-Blind, Placebo-Controlled Study of the Reinforcing Effects of Alprazolam in Patients With Anxiety

NCT00004373

COMPLETED Phase 1

Prepulse Inhibition of Startle in Cocaine Dependence - 7

NCT00015249

COMPLETED NA

Abuse Potential of Buprenorphine and Naloxone in Non-Dependent Opioid Users

NCT00158236

COMPLETED Phase 2

Cocaine Effects in Humans: Physiology and Behavior - 1

NCT00000200

COMPLETED Phase 2

Effects of Nefazodone on Treatment of Female Cocaine Abusers - 3

NCT00000286

COMPLETED Phase 2

Effects of Dextromethorphan on Opioid Tolerance in Methadone Patients - 1

NCT00000352

COMPLETED Phase 1

Buprenorphine and Naloxone Combination Study - 10

NCT00015288

COMPLETED Phase 2

Cocaine Abuse and ADHD - 10

NCT00000275

COMPLETED Phase 1

Buprenorphine Dose Escalation Trial for Treatment of Non-Dependent Opiate Users - 2

NCT00015041

COMPLETED Phase 2

Buprenorphine/Naloxone for Opiate-Dependence Treatment - 1

NCT00015028

COMPLETED Phase 1

Human Dopamine Transported Imaging in Cocaine Abuse: 1 - 1

NCT00000315

COMPLETED Phase 2

Trial of Buprenorphine/Naloxone for Opiate Dependence - 2

NCT00000353

COMPLETED Phase 4

Methamphetamine Abuse Treatment in Patients With AIDS - 1

NCT00000321

COMPLETED Phase 1

Human Dopamine Transported Imaging in Cocaine Abuse: 2 - 2

NCT00000316

COMPLETED Phase 2

Evaluation of Liquid vs. Tablet Buprenorphine - 6

NCT00000341

COMPLETED NA

Effects of Buprenorphine/Naloxone Administered in Different Ways For Treating Opioid Dependence

NCT00134914

COMPLETED

Therapeutic Potential of Kappa-Opioids Against Cocaine - 1

NCT00000323

COMPLETED Phase 2

Risperidone for the Treatment of Cocaine Dependence - 7

NCT00000342

COMPLETED Phase 1

Evaluation of Lofexidine for Treatment of Opioid Withdrawal - 3

NCT00000354

COMPLETED Phase 1

Effects of Phenytoin on Cocaine Use in Humans - 2

NCT00000285

COMPLETED Phase 3

Buprenorphine and Naloxone for the Treatment of Opiate Dependence - 1

NCT00015171

COMPLETED Phase 1

Acute Withdrawal From Smoked Cocaine - 9

NCT00000292

COMPLETED Phase 1

Evaluation of Lofexidine for Treatment of Opiate Withdrawal - 10

NCT00000345

COMPLETED Phase 4

Brain Changes in Stimulant Dependent Subjects - 8

NCT00000343

TERMINATED Phase 2

Serotonin/Dopamine Antagonism of Cocaine Effect: 2 - 2

NCT00000310

COMPLETED Phase 2

Role of Metabolites in Nicotine Dependence (2) - 5

NCT00000288

COMPLETED Phase 2

Pergolide Treatment for Substance Abusers - 4

NCT00000269

COMPLETED Phase 2

Activity Monitoring Assessment of Opiate Withdrawal - 4

NCT00000335

COMPLETED Phase 2

Dextroamphetamine-Cocaine Behavioral Intervention - 5

NCT00000308

COMPLETED Phase 2

Buprenorphine Combination Tablet Feasibility - 1

NCT00000298

COMPLETED NA

Cocaine Abuse and Attention Deficit Disorder - 3

NCT00000268

COMPLETED Phase 2

Naltrexone in Treatment of Cocaine Dependence - 5

NCT00015080

COMPLETED Phase 2

Role of Metabolites in Nicotine Dependence (1) - 1

NCT00000284

COMPLETED

Relapse Patterns in Female Cocaine Users - 4

NCT00000287

COMPLETED Phase 2

Selegiline in Outpatient Treatment for Cocaine Dependence - 1

NCT00000336

COMPLETED Phase 2

Buprenorphine Maintenance Dose Schedule and Treatment Setting - 1

NCT00000318

COMPLETED Phase 2

Alternate-Day Buprenorphine Administration. Phase VII - 8

NCT00000226

COMPLETED Phase 1

Infusion Laboratory: Protocol 1 - Selegeline - 2

NCT00000337

COMPLETED Phase 1

Effects of Buprenorphine and Naloxone in Opiate Addicts - 4

NCT00000355

COMPLETED Phase 2

M-CPP and Fenfluramine in Cocaine Addicts - 3

NCT00000314

COMPLETED Phase 2

Dextroamphetamine as Adjunct in Cocaine/Opiate Dependent Patients - 3

NCT00000306

COMPLETED Phase 2

Flupenthixol Treatment in Schizophrenic Cocaine Abusers - 1

NCT00000266

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What the Pipeline for National Institute on Drug Abuse (NIDA) Shows

According to the ClinicalTrials.gov registry, National Institute on Drug Abuse (NIDA) is linked to 335 US clinical trials across every stage of research activity. Of those, 14 studies are currently recruiting, about 4% of the sponsor's indexed portfolio, and 292 are already marked complete, representing roughly 87% of the total.

The phase mix for National Institute on Drug Abuse (NIDA) reports 30 late-stage studies (Phase 3 and Phase 4 combined) and 202 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for National Institute on Drug Abuse (NIDA) is Cocaine-Related Disorders with 17 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.