National Institute on Drug Abuse (NIDA)

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, National Institute on Drug Abuse (NIDA) sits in the top decile of US sponsors by registered trial count (#108 of 15,742 sponsors by registered trial count).

335 total trials 14 currently recruiting 292 completed early-phase tilt top decile by trial count

National Institute on Drug Abuse (NIDA): 335 sponsored US clinical trials, 14 recruiting.

National Institute on Drug Abuse (NIDA) sponsors 335 registered US clinical trials on ClinicalTrials.gov, 14 of them currently recruiting, and 292 completed. 30 of these trials are in Phase 3-4 (later-stage) and 202 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Cocaine-Related Disorders, with 17 trials.

Top-decile sponsor footprint

National Institute on Drug Abuse (NIDA) ranks in the top decile of sponsors by registered trial count (#108 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

C 71/100

292 of 316 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (92.4%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

335 total, page 7 of 7

COMPLETED Phase 2

Buprenorphine Detox With Two Types of Treatment. BBD I - 10

NCT00000228

COMPLETED Phase 2

Evaluation of a Desipramine Ceiling in Cocaine Abuse - 1

NCT00000245

COMPLETED Phase 2

Flupenthixol Decanoate in Methamphetamine Smoking - 1

NCT00000241

COMPLETED Phase 2

Alternate-Day Buprenorphine Administration. Phase IV - 5

NCT00000223

COMPLETED Phase 2

Alternate Day Buprenorphine Administration, Phase X - 15

NCT00000233

COMPLETED Phase 1

Alternate-Day Buprenorphine. Phase V - 6

NCT00000224

COMPLETED Phase 2

Alternate-Day Buprenorphine Administration. Phase VI - 7

NCT00000225

COMPLETED Phase 2

Buprenorphine Dosing Interval - 5

NCT00000209

COMPLETED

The Genetic Basis for Vulnerability to Substance Abuse

NCT00247819

COMPLETED Phase 1

Alternate-Day Buprenorphine Administration. Phase II - 4

NCT00000222

COMPLETED Phase 2

Buprenorphine Maintenance for Opiate Dependence - 6

NCT00000357

COMPLETED Phase 1

Alternate-Day Buprenorphine Administration. Phase I - 3

NCT00000221

COMPLETED Phase 2

Methadone/Buprenorphine Cross-Over Study - 4

NCT00000208

COMPLETED Phase 2

Buprenorphine Detoxification With Two Types of Treatment. BBD IV - 13

NCT00000231

COMPLETED Phase 1

Gradual Vs. Rapid Buprenorphine Detoxification - 2

NCT00000220

COMPLETED Phase 2

Evaluation of L-alpha-acetylmethadol (LAAM) in Methadone Patients - 5

NCT00000356

COMPLETED Phase 2

Treatment Efficacy for Drug Abuse and AIDS Prevention - 1

NCT00000210

COMPLETED Phase 2

Treatment Efficacy for Drug Abuse and AIDS Prevention - 2

NCT00000211

COMPLETED Phase 2

Propranolol for Treatment of Cocaine Addiction - 2

NCT00000197

COMPLETED Phase 2

Pharmacological Modulation of Cocaine Effects - 1

NCT00000201

COMPLETED Phase 2

Risperidone Treatment in Dually-Diagnosed Individuals - 2

NCT00000267

COMPLETED Phase 2

Buprenorphine Pharmacology Related to Addiction Treatment - 18

NCT00000236

COMPLETED Phase 1

Evaluation of Lofexidine for Treatment of Opioid Withdrawal - 7

NCT00000358

COMPLETED Phase 3

Study Comparing Liquid and Tablet Buprenorphine Formulations - 5

NCT00000302

COMPLETED Phase 2

Effectiveness of the Nicotine Patch in Suppressing Nicotine Withdrawal Symptoms in Women Versus Men - 1

NCT00218140

COMPLETED Phase 2

Buprenorphine Pharmacology Related to Addiction Treatment - 21

NCT00000239

COMPLETED Phase 1

Psychostimulant Abuse - Novel Treatment Approaches - 1

NCT00000325

COMPLETED Phase 2

Buprenorphine/Naloxone for Treatment of Opiate Dependence - 9

NCT00000344

COMPLETED Phase 2

IV Cocaine Abuse: A Laboratory Model - 4

NCT00000215

COMPLETED Phase 4

Pathophysiological Subtyping of Abnormalities in Cocaine Dependence - 9

NCT00015275

COMPLETED Phase 4

Pharmacotherapy and Intensive Treatment - 2

NCT00000218

COMPLETED Phase 2

Alternate Day Buprenorphine Administration, Phase XII - 17

NCT00000235

COMPLETED Phase 1

Alterations in Serotonergic Functions in Cocaine Addicts - 1

NCT00000312

TERMINATED Phase 1

Early Tobacco Abstinence - 5

NCT00224965

TERMINATED Phase 1

Predictive Values of Serotonergic Alterations for Outcome - 2

NCT00000313

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What is open in the National Institute on Drug Abuse (NIDA) pipeline

14 recruiting of 335 indexed (4% open); 292 completed (87%).

Phase mix: 30 late (III/IV) vs 202 early (I/II) (early-phase heavy).

Top condition: Cocaine-Related Disorders (17 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

National Institute on Drug Abuse (NIDA): open-pipeline peers nationwide

Peers matched on 335 registered trials and 4% open enrollment, not the therapeutic-area sidebar.

National Institute on Drug Abuse (NIDA) sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 0100200300400 0%5%10%15%20%25% Total trials Recruiting share National Institute on Drug Abuse (NIDA)BiogenNational Institutes of Health Clinical Center (CC)GenentechCedars-Sinai Medical CenterAkebia TherapeuticsDentsply Sirona Implants and ConsumablesSmith & NephewMedtronic - MITG
National Institute on Drug Abuse (NIDA) sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

National Institute on Drug Abuse (NIDA) sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 335 trials (± recruiting share)

Sponsors near 4% open enrollment (± trial volume)

What to do with this National Institute on Drug Abuse (NIDA) page

335 registered trials is a research-attention snapshot, not an endorsement of National Institute on Drug Abuse (NIDA) or any single study.

  • 14 of National Institute on Drug Abuse (NIDA)'s trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Cocaine-Related Disorders is the condition National Institute on Drug Abuse (NIDA) studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Cocaine-Related Disorders trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. National Institute on Drug Abuse (NIDA) pipeline card: 335 registered trials from official public datasets. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.