National Institute of Allergy and Infectious Diseases (NIAID)

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, National Institute of Allergy and Infectious Diseases (NIAID) sits in the top decile of US sponsors by registered trial count (#5 of 15,742 sponsors by registered trial count).

2,006 total trials 155 currently recruiting 1642 completed early-phase tilt top decile by trial count

National Institute of Allergy and Infectious Diseases (NIAID): 2,006 sponsored US clinical trials, 155 recruiting.

National Institute of Allergy and Infectious Diseases (NIAID) sponsors 2,006 registered US clinical trials on ClinicalTrials.gov, 155 of them currently recruiting, and 1,642 completed. 177 of these trials are in Phase 3-4 (later-stage) and 1,291 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is HIV Infections, with 195 trials.

Top-decile sponsor footprint

National Institute of Allergy and Infectious Diseases (NIAID) ranks in the top decile of sponsors by registered trial count (#5 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

C 68/100

1,642 of 1,802 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (91.1%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

2,006 total, page 28 of 41

COMPLETED

Assessment of a B-Mode Ultrasound Technique for the Measurement of Carotid Artery Intima-Media Thickness

NCT00001904

COMPLETED

A Study of the Long-Term Outcomes of HIV-Positive Patients

NCT00000932

COMPLETED Phase 2

Etanercept to Treat Wegener's Granulomatosis

NCT00001901

COMPLETED

Immune and Viral Status of HIV-Infected Patients After Stopping Combination Antiretroviral Therapy

NCT00001899

COMPLETED Phase 1

Safety and Effectiveness of Immunotherapy With Autologous HIV-Specific CD8 Cells in HIV Infected Adults

NCT00110578

COMPLETED Phase 1

Drug Interactions Among Anti-HIV Agents

NCT00001766

COMPLETED Phase 2

The Effects of Giving Interleukin-2 (IL-2) Plus Anti-HIV Therapy to HIV-Positive Patients With CD4 Cell Counts of at Least 350 Cells/mm3

NCT00000825

COMPLETED Phase 1

Subcutaneously Administered Interleukin-12 Therapy in HIV-Infected Patients With Disseminated Mycobacterium Avium Complex Infection

NCT00001763

COMPLETED Phase 1

Stem Cell Transplant Following Low-Intensity Chemotherapy to Treat Chronic Granulomatous Disease

NCT00001765

COMPLETED Phase 1

Mycophenolate Mofetil to Treat Wegener's Granulomatosis and Related Vascular Inflammatory Conditions

NCT00001764

TERMINATED NA

Use of Labeled Glucose to Study Lymphocyte Replication and Survival in HIV-Infected Patients

NCT00001651

COMPLETED

Magnetic Resonance Imaging of the Face and Bones

NCT00001762

COMPLETED Phase 1

Phase I Trial of Recombinant Human Interleukin-10 (SCH 52000) in Patients With Wegener's Granulomatosis

NCT00001761

TERMINATED Phase 1

Evaluation of the Safety of Varivax® in Pediatric Renal Transplant Recipients

NCT00005009

COMPLETED

Cytokine Production Patterns in Patients With Systemic Mastocytosis Compared With Atopic Dermatitis and Healthy Individuals

NCT00001760

COMPLETED

Study of Mast Cell Precursors

NCT00001756

COMPLETED

Long-Term Effects of HAART in Youth With Stronger Immune Systems Versus Youth With Weaker Immune Systems

NCT00001097

COMPLETED

Assessment of Lung Inflammation in Patients With Atopic Asthma Using Positron Emission Tomography

NCT00001759

COMPLETED Phase 3

Acyclovir for Herpes Infections Involving the Central Nervous System in Neonates

NCT00031460

COMPLETED Phase 2

Continued Antiretroviral Therapy With Abacavir, Amprenavir and Efavirenz

NCT00001758

COMPLETED Phase 3

An Open Label, Non-Comparative, Multicenter, Phase III Trial of the Efficacy, Safety and Toleration of Voriconazole in the Primary or Secondary Treatment of Invasive Fungal Infections

NCT00001757

TERMINATED Phase 3

Ribavirin to Prevent RSV Pneumonia in Bone Marrow Transplant Patients

NCT00031473

COMPLETED Phase 1

Development of a New HIV Vaccine

NCT00051922

COMPLETED Phase 1

Safety, Tolerability, and Anti-HIV Activity of DMP 266 (Efavirenz) in Combination With Nelfinavir in HIV-Positive Children

NCT00000893

COMPLETED NA

Long-Term Assessment for Metabolic, Cardiovascular and Neurologic Problems in HIV-Infected Patients With Increased CD4 Cells Counts Following Anti-HIV Therapy

NCT00000883

COMPLETED

Use of Bromodeoxyuridine to Study White Blood Cell Replication and Survival in HIV-Infected Patients

NCT00001650

TERMINATED

Setting up a Blood Bank for Gene Therapy in HIV-Infected Infants

NCT00000917

COMPLETED

Structure of the Herpes Simplex Virus Receptor

NCT00001648

COMPLETED Phase 3

Voriconazole vs. Amphotericin B in the Treatment of Invasive Aspergillosis

NCT00001646

COMPLETED Phase 3

Valaciclovir to Prevent Transmission of Herpes Simplex Virus

NCT00001649

COMPLETED

A Pilot Study of the Short-Term Effects of Antiretroviral Management Based on Plasma Genotypic Antiretroviral Resistance Testing (GART) Compared With Antiretroviral Management Without Plasma GART

NCT00000874

COMPLETED Phase 1

White Blood Cell Infusions to Treat HIV Infection

NCT00001647

COMPLETED Phase 1

A Phase I Safety and Immunogenicity Trial of the Facilitated HIV-1 Gag-Pol DNA Vaccine (APL-400-047, Apollon, Inc.) Given Intramuscularly by Needle and Syringe or Biojector 2000 Needle-Free Jet Injection System in HIV-1 Uninfected Adult Volunteers

NCT00001088

COMPLETED Phase 1

Use of Combined Antiretroviral Therapy to Determine Sites of Persistent HIV Infection

NCT00001644

COMPLETED Phase 3

The Safety and Effectiveness of Adefovir Dipivoxil in the Treatment of HIV-Infected Patients

NCT00001082

COMPLETED Phase 2

A Study to Evaluate the Use of Memantine In Combination With Anti-HIV Drugs to Treat AIDS Dementia Complex (ADC)

NCT00000867

TERMINATED

Evaluation and Long-Term Follow-Up of Patients With Allergic and Inflammatory Disorders

NCT00557895

COMPLETED Phase 2

The Effects of Prednisone on HIV Levels and the Immune System

NCT00000921

COMPLETED Phase 4

Fluconazole Prophylaxis of Thrush in AIDS

NCT00001542

COMPLETED

A Comparison of Two Caloric Supplements in the Prevention of Weight Loss in Patients With AIDS Who Take Daily Multivitamin and Mineral Supplements

NCT00001077

COMPLETED

Genetic Studies of X-linked Lymphoproliferative Disease

NCT00359411

COMPLETED

The Use of Bacteriophage Phi X174 to Assess the Immune Competence of HIV-Infected Patients In Vivo

NCT00001540

COMPLETED

Analysis of Bronchial Tissue and Fluid in Patients With Wegener's Granulomatosis

NCT00001541

COMPLETED Phase 1

Phase I Study of APL 400-003, a Candidate HIV Vaccine, in HIV-Negative Volunteers

NCT00001538

COMPLETED

Monitoring Patients for Developing Communicable and Opportunistic Infections and for Responding to Therapy

NCT00001477

COMPLETED Phase 1

Gene Therapy for Chronic Granulomatous Diseases - Long-term Follow-up

NCT00001476

COMPLETED Phase 2

Home Treatment of HIV-Infected Patients With Interleukin-2 With or Without a Tumor Necrosis Factor Antagonist

NCT00001475

COMPLETED Phase 2

Pharmacodynamics of Intermittent IL-2 Infusions in HIV Seropositive Patients

NCT00001474

COMPLETED

Cyclophosphamide and Prednisone Followed by Methotrexate To Treat Vasculitides

NCT00001473

COMPLETED

Evaluation and Monitoring of Patients With HIV Infectionn

NCT00557570

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Phase Distribution

PhaseTrial count
Phase 1 858
Phase 2 433
Phase 3 123
Phase 4 54

What is open in the National Institute of Allergy and Infectious Diseases (NIAID) pipeline

155 recruiting of 2,006 indexed (8% open); 1,642 completed (82%).

Phase mix: 177 late (III/IV) vs 1,291 early (I/II) (early-phase heavy).

Top condition: HIV Infections (195 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

National Institute of Allergy and Infectious Diseases (NIAID): open-pipeline peers nationwide

Peers matched on 2,006 registered trials and 8% open enrollment, not the therapeutic-area sidebar.

National Institute of Allergy and Infectious Diseases (NIAID) sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 05001,0001,5002,0002,500 5%10%15%20% Total trials Recruiting share National Institute of Allergy and Infectious Diseases (NIAID)Massachusetts General HospitalMemorial Sloan Kettering Cancer CenterPfizerStanford UniversityAlumisAndrei IagaruBioXcel TherapeuticsCorporal Michael J. Crescenz VA Medical Center
National Institute of Allergy and Infectious Diseases (NIAID) sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

National Institute of Allergy and Infectious Diseases (NIAID) sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 2,006 trials (± recruiting share)

Sponsors near 8% open enrollment (± trial volume)

What to do with this National Institute of Allergy and Infectious Diseases (NIAID) page

2,006 registered trials is a research-attention snapshot, not an endorsement of National Institute of Allergy and Infectious Diseases (NIAID) or any single study.

  • 155 of National Institute of Allergy and Infectious Diseases (NIAID)'s trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • HIV Infections is the condition National Institute of Allergy and Infectious Diseases (NIAID) studies most, compare against other sponsors active in the same condition before evaluating a specific study. See HIV Infections trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. National Institute of Allergy and Infectious Diseases (NIAID) pipeline card: 2,006 registered trials from official public datasets. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.