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NCT00001756 · ClinicalTrials.gov registry record
Study of Mast Cell Precursors
A clinical trial, sponsored by National Institute of Allergy and Infectious Diseases (NIAID).
- Completed
- Registry status
- 202
- Enrollment target
NCT00001756: Completed study, sponsored by National Institute of Allergy and Infectious Diseases (NIAID).
NCT00001756 is a clinical trial that has completed, run by National Institute of Allergy and Infectious Diseases (NIAID). The registered enrollment target is 202 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00001756 has completed, sponsored by National Institute of Allergy and Infectious Diseases (NIAID).
- COMPLETED
- Registry status
- 202 participants
- Enrollment target
Study Summary
This study will investigate mast cell precursors that circulate in the blood. In a group of diseases collectively known as mastocytosis, mast cells accumulate in abnormal amounts in the skin, lymphoid tissues, bone marrow, liver and spleen. Some forms of mastocytosis have a generally good prognosis; for others, the prognosis is poorer. There is no known cure for any form of the disease. A better understanding of mast cells and how they respond to certain substances may provide insights that will lead to effective treatments for mastocytosis. Patients with systemic mastocytosis and normal healthy volunteers between the ages of 20 and 60 may be eligible for this 8-day study. Participants will undergo the following procedures: * Day 1 Medical history, physical examination, and blood tests to assess general health status * Days 2 through 6 Daily injections under the skin of G-CSF a hormone that stimulates white blood cell production * Day 7 Leukapheresis a procedure for collecting large numbers of white blood cells. In leukapheresis, blood is drawn through a needle placed in an arm and channeled into a cell separator machine. The white cells are collected and the rest of the blood is returned to the body through a needle in the other arm. The procedure takes up to 3 hours. * Days 7 and 8 Blood draw (about 1 teaspoon) to monitor white blood cell counts.
Primary Outcome
Use of G-CSF administration healthy volunteers to mobilize and enhance CD34+ hematopoietic progenitor cell numbers into the peripheral blood in order to culture and characterize human mast cells, study and characterize CD34+ -derived human mast cells.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 202 participants |
| Start Date | 1997-12-03 |
| Est. Completion | 2022-11-03 |
What the finished NCT00001756 record still lists
NCT00001756 is an observational study that tracks outcomes without assigning an intervention. The registered 202 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 0 interventions.
NCT00001756 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00001756 about?
NCT00001756 is a clinical study titled "Study of Mast Cell Precursors". This study will investigate mast cell precursors that circulate in the blood. In a group of diseases collectively known as mastocytosis, mast cells accumulate in abnormal amounts in the skin, lymphoid tissues, bone marrow, liver and spleen. Some forms of mastocytosis have a generally good prognosis;...
What is the current status of trial NCT00001756?
This trial is currently completed. The enrollment target is 202 participants. The study started on 1997-12-03. Estimated completion is 2022-11-03.
Who is sponsoring clinical trial NCT00001756?
This trial is sponsored by National Institute of Allergy and Infectious Diseases (NIAID), which has 2,006 total clinical trials registered on ClinicalTrials.gov.
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