Duke University

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, Duke University sits in the top decile of US sponsors by registered trial count (#9 of 15,742 sponsors by registered trial count).

1,725 total trials 187 currently recruiting 1244 completed early-phase tilt top decile by trial count

Duke University: 1,725 sponsored US clinical trials, 187 recruiting.

Duke University sponsors 1,725 registered US clinical trials on ClinicalTrials.gov, 187 of them currently recruiting, and 1,244 completed. 175 of these trials are in Phase 3-4 (later-stage) and 311 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Obesity, with 15 trials.

Top-decile sponsor footprint

Duke University ranks in the top decile of sponsors by registered trial count (#9 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

D 55/100

1,244 of 1,444 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (86.1%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

1,725 total, page 10 of 35

COMPLETED NA

Assessment of InfraScanner 2000™ in Detecting Subdural and Epidural Hematomas

NCT04505293

COMPLETED Phase 4

Simultaneous mRNA COVID-19 and IIV4 Vaccination Study

NCT05028361

COMPLETED NA

Test to Stay in School: COVID-19 Testing Following Exposure in School Communities

NCT05052580

COMPLETED Phase 4

Simultaneous RZV and aIIV4 Vaccination

NCT05007041

COMPLETED NA

Ipsilateral Peripheral Intravenous Access Procedures (The iPIVAP Study)

NCT04570722

COMPLETED NA

An mHealth Symptom Management Intervention for Colorectal Cancer Patients (mCOPE)

NCT04763174

COMPLETED NA

Amplifying Sensation in Underactive Bladder

NCT04516434

COMPLETED NA

Increasing Vaccine Uptake Among Adolescents in the Rural South

NCT04999267

COMPLETED NA

PEEP Mask for Tracheobronchomalacia-Induced Cough

NCT04169282

COMPLETED

Steroid Metabolism in Obese and Non-Obese Pediatric Patients Hospitalized for Status Asthmaticus

NCT04874610

COMPLETED NA

A Depression and Opioid Pragmatic Trial in Pharmacogenetics (Depression Trial)

NCT05966155

COMPLETED Phase 1

Protecting With ARNI Against Cardiac Consequences of Coronavirus Disease 2019

NCT04883528

COMPLETED NA

A Transition of Care Model From Hospital to Community for Hispanic/Latino Adult Patients With Diabetes.

NCT04864639

TERMINATED NA

VAC Bioburden Wound Care Assessment

NCT04826965

COMPLETED

Balance Function in Patients Post Corona Virus Disease 2019 (COVID-19)

NCT04914364

COMPLETED

Exploring Compensation to Maintain Cognitive Function in Adults Newly Diagnosed With Brain Cancer

NCT04075370

COMPLETED NA

Weight Loss and Exercise To Improve Rheumatoid Arthritis Cardiovascular Risk

NCT04356183

TERMINATED

Development and Validation of a Model to Predict Fast Progression in Glaucoma

NCT04454190

COMPLETED

COA-APTIC Caregiver Concept Elicitation Study

NCT04392180

COMPLETED NA

EngagINg the COmmunity to Reduce Preterm Birth Via Adherence To an Individualized Prematurity Prevention Plan

NCT04933812

COMPLETED NA

TOPS for African American Breast Cancer Survivors

NCT04741802

COMPLETED

Human Use Condition Study- Evaluation of Implanted Leads in Humans

NCT04320849

COMPLETED NA

Implementation of Cognitive Stimulation Therapy

NCT04754932

COMPLETED

Observational Maternal COVID-19 Vaccination Study

NCT04826640

COMPLETED Phase 1

The Role of Nicotine and Non-Nicotine Alkaloids in E-Cigarette Use and Dependence

NCT02590393

COMPLETED

Ultrasound After Total Shoulder Arthroplasty

NCT04416932

COMPLETED NA

A Self-directed Mobile Mindfulness Intervention to Address Distress and Burnout in Frontline Healthcare Workers

NCT04816708

COMPLETED NA

Resilience Measurement in Older Adults With Late-Stage Lung Cancer

NCT04825912

COMPLETED

Pulmonary Inflammation and Microbiome Changes With Bariatric Surgery in Obese Asthma

NCT04247971

COMPLETED NA

Efficacy and Safety of ICD Remote Monitored Exercise Testing to Improve Heart Failure Outcomes: REMOTE HF-ACTION

NCT04629066

COMPLETED

COVID-19 Surveillance and Exposure Testing in School Communities

NCT04831866

COMPLETED NA

Evaluation of Unilateral vs Bilateral Hearing Aids for the Treatment of Age-related Hearing Loss

NCT04739436

COMPLETED NA

Enhancing Physical Function in the Long-term for Older Adults

NCT04490356

COMPLETED

Latinx Teen Depression Treatment Study

NCT04819295

COMPLETED NA

Active Dads Healthy Families

NCT04505085

TERMINATED Phase 4

Opioid & Steroid Use Following Tonsillectomy in Pediatric Patients

NCT04541147

COMPLETED NA

Childhood Obesity Microbiome Study

NCT04770311

TERMINATED NA

AirFLO2 Treatment for Hypoxia and/or Tachypnea in Patients With COVID-19

NCT04649775

COMPLETED NA

Outcomes of a Self-guided Versus Therapist-guided Online Mental Health Treatment

NCT04810988

COMPLETED

Rapid Acceleration for Diagnostics in Underserved Populations: Home Testing

NCT04949243

COMPLETED NA

Mindfulness and CBT for Sleep

NCT04736056

COMPLETED

Learning Health for Pediatric Complex Care Integration (PCCI)

NCT05056480

COMPLETED NA

Impact of Reduced Cannabis Use on Functional Outcomes (R33 Phase)

NCT04567238

TERMINATED Phase 4

Randomized Controlled Trial of Talc Instillation In Addition To Daily Drainage Through a Tunneled Pleural Catheter to Improve Rates of Outpatient Pleurodesis in Patients With Malignant Pleural Effusion

NCT04792970

COMPLETED NA

An Evaluation of Insomnia Treatment to Reduce Cardiovascular Risk in Patients With Posttraumatic Stress Disorder

NCT04498754

COMPLETED

Screening for Colonization With Resistant Enterobacterales in Neutropenic Patients With Hematologic Malignancies

NCT04710212

COMPLETED NA

Presyncope (Syncope) Prevention Study

NCT04772755

COMPLETED NA

A Depression and Opioid Pragmatic Trial in Pharmacogenetics (Acute Pain Trial)

NCT05966129

COMPLETED NA

Evaluation of Full Face Snorkel Masks (FFSMs)

NCT04783688

COMPLETED NA

Digital Intervention To Improve Diet Quality

NCT04098016

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Phase Distribution

PhaseTrial count
Phase 1 136
Phase 2 175
Phase 3 41
Phase 4 134

What is open in the Duke University pipeline

187 recruiting of 1,725 indexed (11% open); 1,244 completed (72%).

Phase mix: 175 late (III/IV) vs 311 early (I/II) (early-phase heavy).

Top condition: Obesity (15 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

Duke University: open-pipeline peers nationwide

Peers matched on 1,725 registered trials and 11% open enrollment, not the therapeutic-area sidebar.

Duke University sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 05001,0001,5002,000 5%10%15%20% Total trials Recruiting share Duke UniversityUniversity of California, San FranciscoStanford UniversityVA Office of Research and DevelopmentPfizerCarnegie Mellon UniversityCAMC Health SystemUConn HealthHartford Hospital
Duke University sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

Duke University sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 1,725 trials (± recruiting share)

Sponsors near 11% open enrollment (± trial volume)

What to do with this Duke University page

1,725 registered trials is a research-attention snapshot, not an endorsement of Duke University or any single study.

  • 187 of Duke University's trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Obesity is the condition Duke University studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Obesity trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Duke University pipeline card: 1,725 registered trials from official public datasets.Report a data error.