Alliance for Clinical Trials in Oncology

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, Alliance for Clinical Trials in Oncology sits in the top decile of US sponsors by registered trial count (#80 of 15,742 sponsors by registered trial count).

446 total trials 29 currently recruiting 346 completed early-phase tilt top decile by trial count

Alliance for Clinical Trials in Oncology: 446 sponsored US clinical trials, 29 recruiting.

Alliance for Clinical Trials in Oncology sponsors 446 registered US clinical trials on ClinicalTrials.gov, 29 of them currently recruiting, and 346 completed. 142 of these trials are in Phase 3-4 (later-stage) and 235 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Breast Cancer, with 19 trials.

Top-decile sponsor footprint

Alliance for Clinical Trials in Oncology ranks in the top decile of sponsors by registered trial count (#80 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

C 69/100

346 of 377 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (91.8%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

446 total, page 9 of 9

COMPLETED Phase 2

Irinotecan in Treating Patients With Refractory Metastatic Breast Cancer

NCT00003351
COMPLETED Phase 3

Carboplatin, Paclitaxel, and Radiation Therapy in Treating Patients With Stage III Non-small Cell Lung Cancer That Cannot Be Removed During Surgery

NCT00003387
COMPLETED

Genetic Study of Patients and Families With a History of Colorectal Cancer

NCT00003648
TERMINATED

Quality of Life Assessment of Patients Receiving Treatment for Esophageal Cancer [Companion to CALGB-9781]

NCT00003381
COMPLETED Phase 3

Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With Stage IIIA Non-small Cell Lung Cancer

NCT00003317
COMPLETED Phase 2

Hormone Therapy in Treating Patients With Prostate Cancer

NCT00003323
COMPLETED Phase 3

Cisplatin Plus Etoposide With or Without Paclitaxel in Treating Patients With Extensive-Stage Small Cell Lung Cancer

NCT00003299
COMPLETED Phase 2

Topotecan and Paclitaxel in Treating Patients With Recurrent or Refractory Small Cell Lung Cancer

NCT00003281
COMPLETED Phase 2

Fludarabine and Monoclonal Antibody Therapy in Treating Patients With Untreated B-cell Chronic Lymphocytic Leukemia

NCT00003248
COMPLETED Phase 2

Radiation Therapy and High-Dose Corticosteroids in Treating Older Patients With Primary CNS Non-Hodgkin's Lymphoma

NCT00003278
COMPLETED Phase 2

Irinotecan in Treating Patients With Advanced Gallbladder or Bile Duct Cancer

NCT00003276
COMPLETED Phase 2

Fludarabine Plus Octreotide in Treating Patients With Relapsed Low-Grade Non-Hodgkin's Lymphoma

NCT00002779
COMPLETED Phase 1

Radiation Therapy and Chemotherapy in Treating Patients With Cancer of the Pancreas or Stomach

NCT00003157
COMPLETED Phase 3

Glutamine in Preventing Acute Diarrhea in Patients With Pelvic Cancer

NCT00003170
COMPLETED Phase 2

Irinotecan in Treating Patients With Recurrent Glioma

NCT00003134
COMPLETED Phase 2

Irinotecan in Treating Patients With Advanced Cancer of the Stomach

NCT00003137
COMPLETED Phase 2

Paclitaxel in Treating Women With Recurrent Solid Tumors

NCT00003130
COMPLETED Phase 3

Paclitaxel With or Without Carboplatin in Treating Patients With Advanced Non-small Cell Lung Cancer

NCT00003117
COMPLETED Phase 3

Surgery With or Without Chemotherapy and Radiation Therapy in Treating Patients With Cancer of the Esophagus

NCT00003118
COMPLETED

Genetic Markers in Patients With Colorectal Cancer

NCT00014079
COMPLETED Phase 3

Combination Chemotherapy in Treating Patients With Breast Cancer

NCT00003088
COMPLETED Phase 3

Paclitaxel in Treating Older Patients With Solid Tumors

NCT00003092
COMPLETED Phase 2

Gemcitabine and Cisplatin in Treating Patients With Metastatic Breast Cancer

NCT00002998
COMPLETED Phase 1

Interleukin-2 Plus Monoclonal Antibody Therapy in Treating Patients With Solid Tumors

NCT00002994
COMPLETED Phase 2

Surgery in Treating Patients With Prostate Cancer

NCT00002938
COMPLETED

Detection of Early Metastases in Patients With Stage I Non-small Cell Lung Cancer

NCT00003006
COMPLETED Phase 2

Radiation Therapy With Androgen Suppression in Treating Patients With Prostate Cancer

NCT00002889
COMPLETED

Study of Bone Marrow and Blood Samples in Patients With Untreated Acute Myeloid Leukemia or Acute Lymphoblastic Leukemia Enrolled on Clinical Trial CALGB-9621 or CALGB-9720

NCT01004965
COMPLETED

Gene Mutations in Patients With Advanced Prostate Cancer That Is Not Responsive to Hormone Therapy

NCT00002924
COMPLETED Phase 2

Cladribine in Patients With Mantle Cell Lymphoma

NCT00002879
COMPLETED Phase 2

Etoposide in Treating Patients With Relapsed Non-Hodgkin's Lymphoma

NCT00002880
COMPLETED Phase 3

Antiandrogen Withdrawal in Treating Patients With Hormone-Refractory Prostate Cancer

NCT00002760
COMPLETED Phase 2

Chemotherapy Followed by Radiation Therapy in Treating Adults With Supratentorial Glioma

NCT00002806
COMPLETED

Correlation of Menstrual Cycle Phase at Time of Primary Surgery With 5-Year Disease-Free Survival in Women With Stage I or Stage II Breast Cancer

NCT00002762
COMPLETED Phase 2

Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Acute Myeloid Leukemia in Second Remission

NCT00002768
COMPLETED Phase 3

Combination Chemotherapy in Treating Patients With Liver Metastases From Colorectal Cancer

NCT00002716
COMPLETED

Study of Tissue and Blood Samples From Patients With Low-Grade Glioma

NCT01004523
COMPLETED

Study of Tissue and Blood Samples From Patients With High-Grade Glioma

NCT01004887
COMPLETED Phase 1

Omega-3 Fatty Acids in Treating Patients With Advanced Cancer Who Have Significant Weight Loss

NCT00003077
COMPLETED Phase 2

Chemotherapy and Whole-Brain Radiation Therapy in Treating Patients With Primary Central Nervous System Non- Hodgkin's Lymphoma

NCT00002676
COMPLETED Phase 3

Talc in Treating Patients With Malignant Pleural Effusion

NCT00002622
COMPLETED Phase 2

Video-Assisted Surgery Followed by Radiation Therapy in Treating Patients With Stage I Non-small Cell Lung Cancer and Poor Heart and Lung Function

NCT00002624
COMPLETED Phase 3

Laparoscopic-Assisted Surgery Compared With Open Surgery in Treating Patients With Colon Cancer

NCT00002575
COMPLETED Phase 3

Aspirin in Treating Patients With Colorectal Cancer That Has Been Surgically Removed

NCT00002527
COMPLETED Phase 2

Cyclophosphamide and Filgrastim in Treating Patients With Stage IV, Relapsed, or Refractory Low-Grade Follicular Non-Hodgkin's Lymphoma

NCT00002501
COMPLETED Phase 2

Combination Chemotherapy in Treating Patients With Non-Hodgkin's Lymphoma or Acute Lymphocytic Leukemia

NCT00002494
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Phase Distribution

PhaseTrial count
Phase 1 26
Phase 2 209
Phase 3 142

Therapeutic Areas

Breast Cancer 19
Lung Cancer 17
Lymphoma 17
Leukemia 9
Colorectal Cancer 9
Prostate Cancer 8
Unspecified Adult Solid Tumor, Protocol Specific 6
Brain and Central Nervous System Tumors 5
Anatomic Stage II Breast Cancer AJCC v8 5
Esophageal Cancer 5

What is open in the Alliance for Clinical Trials in Oncology pipeline

29 recruiting of 446 indexed (7% open); 346 completed (78%).

Phase mix: 142 late (III/IV) vs 235 early (I/II) (early-phase heavy).

Top condition: Breast Cancer (19 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

Alliance for Clinical Trials in Oncology: open-pipeline peers nationwide

Peers matched on 446 registered trials and 7% open enrollment, not the therapeutic-area sidebar.

Alliance for Clinical Trials in Oncology sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 0100200300400500 5%10%15%20%25% Total trials Recruiting share Alliance for Clinical Trials in OncologyMedical College of WisconsinUniversity of VirginiaChildren's Hospital of PhiladelphiaNovo Nordisk A/SNational Institutes of Health Clinical Center (CC)Insmed IncorporatedNICHD Neonatal Research NetworkHennepin Healthcare Research Institute
Alliance for Clinical Trials in Oncology sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

Alliance for Clinical Trials in Oncology sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 446 trials (± recruiting share)

Sponsors near 7% open enrollment (± trial volume)

Related

Read our methodology - how this data is sourced, computed, and verified.

What to do with this Alliance for Clinical Trials in Oncology page

446 registered trials is a research-attention snapshot, not an endorsement of Alliance for Clinical Trials in Oncology or any single study.

  • 29 of Alliance for Clinical Trials in Oncology's trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Breast Cancer is the condition Alliance for Clinical Trials in Oncology studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Breast Cancer trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. Alliance for Clinical Trials in Oncology pipeline card: 446 registered trials from official public datasets. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.