Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Xerostomia: early-phase trial registry
2 of 14 indexed Xerostomia trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #1,230 of 28,707 conditions by registered trial count.
14 US clinical trials · 2 currently recruiting · #1,230 of 28,707 conditions by registered trial count
Xerostomia: 14 US clinical trials tracked, 2 recruiting.
Xerostomia is the subject of 14 registered US clinical trials on ClinicalTrials.gov, 2 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 4 in Phase 1-2 (earlier-stage). The most active sponsor is Tufts University, running 2 of these trials.
Enrollment posture brief
Registry condition xerostomia
OPEN 2 | RECR 14% | LATE 2 | EARLY 4 | RANK #1230 | SPON 2
Volume-matched condition peers
Nearest open-share peer: Adverse Drug Events (14% recruiting · 7 trials)
Xerostomia lists 2 open slots (14% of 14 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Xerostomia on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Xerostomia is recruiting below its size-band peers.
2 of 14 indexed trials (14.3%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Xerostomia trials is spread across many organizations.
Tufts University accounts for 2 of 14 trials (14.3%). 11 distinct sponsors appear on at least one study for this condition label.
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Most Xerostomia trials plan to enrol fewer than 100 people.
Median target enrolment is 54 among the 14 trials that report a genuine target (sentinel values excluded). 11 of those (78.6%) plan for fewer than 100 participants.
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Xerostomia research is mostly interventional.
11 interventional and 3 observational studies make up this index (78.6% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
14 total, page 1 of 1
d-Limonene +Radiation +PlatinumBasedChemo for Xerostomia Prevention in LocallyAdvanced HNSCC
Stanford University
NCT04392622
Dose-Escalation Trial of Mesenchymal Stromal Cells in Patients With Medical Xerostomia
University of Wisconsin, Madison
NCT06392711
Observational Study of Dental Outcomes in Head and Neck Cancer Patients
Wake Forest University Health Sciences
NCT02057510
Dry Mouth Toothpaste Study - Comparing Two Toothpastes With Arginine
Tufts University
NCT06365047
Effect of Whitening Agent With Emulsion Gel in Saliva and Halitosis
Tufts University
NCT06194123
Study Transplanting Bone Marrow Cells Into Salivary Glands to Treat Dry Mouth Caused by Radiation Therapy
University of Wisconsin, Madison
NCT05820711
Prospective Evaluation of Patient Reported Xerostomia After Whole Brain Radiation
UNC Lineberger Comprehensive Cancer Center
NCT02682199
Potential of an Experimental Mouthwash Formulation to Reduce Dry Mouth Symptoms
GlaxoSmithKline
NCT02641912
Effect of Childhood Radioiodine Therapy on Salivary Function
Boston Children's Hospital
NCT02375451
Consumer Perception of an Experimental Mouthwash After a Single Use in Dry Mouth Subjects
GlaxoSmithKline
NCT03005041
Study of the Effectiveness of Cevimeline on Oral Health in Patients With Radiation Induced Xerostomia
American Academy of Otolaryngology-Head and Neck Surgery Foundation
NCT00466388
Evaluation of the Efficacy of 3M Dry Mouth Moisturizing Spray
Solventum US
NCT04186806
SaliPen Human Factors Study for OTC Labeling
Saliwell
NCT05058430
An Evaluation of the Impact of a Single Dose of P-552 on Oral Mucosal Wetness
Parion Sciences
NCT01369589
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 4 |
| Phase 3 | 1 |
| Phase 4 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Xerostomia records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Xerostomia trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Xerostomia page
14 registered trials, 2 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 2 Xerostomia trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Tufts University sponsors the most Xerostomia trials on record, review their full trial history before evaluating a specific study. See Tufts University's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Xerostomia condition card totals 14 registered trials; most-linked intervention Biotene mouthwash; top US site state Massachusetts. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.