Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Xerostomia clinical trials
2 of 14 indexed Xerostomia trials are currently recruiting.
14 US clinical trials · 2 currently recruiting
Xerostomia is the subject of 14 registered US clinical trials on ClinicalTrials.gov, 2 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 4 in Phase 1-2 (earlier-stage). The most active sponsor is Tufts University, running 2 of these trials.
The research picture
Xerostomia has 14 registered US clinical trials, 2 of them open to new participants right now, about 14% of the total.
- 2
- recruiting participants now
- 14%
- of trials open to enrollment
- 2
- in Phase 3–4 (later-stage)
- 2
- top sponsor: Tufts University
Active & Recent Trials
14 total, page 1 of 1
d-Limonene +Radiation +PlatinumBasedChemo for Xerostomia Prevention in LocallyAdvanced HNSCC
Stanford University
NCT04392622
Dose-Escalation Trial of Mesenchymal Stromal Cells in Patients With Medical Xerostomia
University of Wisconsin, Madison
NCT06392711
Observational Study of Dental Outcomes in Head and Neck Cancer Patients
Wake Forest University Health Sciences
NCT02057510
Dry Mouth Toothpaste Study - Comparing Two Toothpastes With Arginine
Tufts University
NCT06365047
Effect of Whitening Agent With Emulsion Gel in Saliva and Halitosis
Tufts University
NCT06194123
Study Transplanting Bone Marrow Cells Into Salivary Glands to Treat Dry Mouth Caused by Radiation Therapy
University of Wisconsin, Madison
NCT05820711
Prospective Evaluation of Patient Reported Xerostomia After Whole Brain Radiation
UNC Lineberger Comprehensive Cancer Center
NCT02682199
Potential of an Experimental Mouthwash Formulation to Reduce Dry Mouth Symptoms
GlaxoSmithKline
NCT02641912
Effect of Childhood Radioiodine Therapy on Salivary Function
Boston Children's Hospital
NCT02375451
Consumer Perception of an Experimental Mouthwash After a Single Use in Dry Mouth Subjects
GlaxoSmithKline
NCT03005041
Study of the Effectiveness of Cevimeline on Oral Health in Patients With Radiation Induced Xerostomia
American Academy of Otolaryngology-Head and Neck Surgery Foundation
NCT00466388
Evaluation of the Efficacy of 3M Dry Mouth Moisturizing Spray
Solventum US
NCT04186806
SaliPen Human Factors Study for OTC Labeling
Saliwell
NCT05058430
An Evaluation of the Impact of a Single Dose of P-552 on Oral Mucosal Wetness
Parion Sciences
NCT01369589
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 4 |
| Phase 3 | 1 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Xerostomia Trial Landscape
14 indexed Xerostomia studies · 2 recruiting (14%).
Phase mix: 2 late (III/IV) vs 4 early (I/II).
Top sponsor: Tufts University (2 trials), 9 others listed. 14 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Xerostomia?
PlainTrial tracks 14 US clinical trials for Xerostomia, of which 2 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Xerostomia?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.