Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT00466388 · ClinicalTrials.gov registry record · Phase 4
Study of the Effectiveness of Cevimeline on Oral Health in Patients With Radiation Induced Xerostomia
A Phase 4 study of Xerostomia, sponsored by American Academy of Otolaryngology-Head and Neck Surgery Foundation.
- Completed
- Registry status
- Phase 4
- Development phase
- 54
- Enrollment target
- 7
- Study locations
NCT00466388: Completed Phase 4 study of Xerostomia, sponsored by American Academy of Otolaryngology-Head and Neck Surgery Foundation.
NCT00466388 is a Phase 4 study of Xerostomia that has completed, run by American Academy of Otolaryngology-Head and Neck Surgery Foundation. The registered enrollment target is 54 participants, below the 91-participant average among 13 other Xerostomia trials with a reported enrollment target (41% lower). The trial reports 7 study locations across 6 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00466388, a Phase 4 study of Xerostomia, has completed, sponsored by American Academy of Otolaryngology-Head and Neck Surgery Foundation.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 54 participants
- Enrollment target
- 7
- Study locations
Study Summary
The purpose of this study is to determine the effectiveness of cevimeline (versus placebo) on the oral health of patients who have dry mouth which was caused by radiation therapy that was given for treatment of head and/or neck cancer.
Conditions Studied
Interventions
- DRUG Cevimeline
Study Locations (7)
Pennsylvania
- Associated Otolaryngologist - Palmyra
- University of Pittsburgh - Pittsburgh
Colorado
- - Colorado Springs
Illinois
- Carle Clinic Association - Urbana
Kansas
- University of Kansas Medical Center - Kansas City
Kentucky
- Commonwealth Ear, Nose and Throat - Louisville
Virginia
- Fauquier ENT Consultants - Warrenton
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 54 participants |
| Start Date | 2007-05 |
| Est. Completion | 2009-08 |
| Phase | Phase 4 |
What the finished NCT00466388 record still lists
NCT00466388 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 54 participants, a relatively small participant target, below the 91-participant average among 13 other Xerostomia trials with a reported enrollment target (41% lower).
The record links to 1 condition, with Xerostomia appearing as the primary indexed condition, and to 1 intervention - of which Cevimeline is the first listed.
NCT00466388 lists 7 locations in 6 states (Pennsylvania, Colorado, Illinois).
Frequently Asked Questions
What is clinical trial NCT00466388 about?
NCT00466388 is a clinical study titled "Study of the Effectiveness of Cevimeline on Oral Health in Patients With Radiation Induced Xerostomia". The purpose of this study is to determine the effectiveness of cevimeline (versus placebo) on the oral health of patients who have dry mouth which was caused by radiation therapy that was given for treatment of head and/or neck cancer.
What is the current status of trial NCT00466388?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 54 participants. The study started on 2007-05. Estimated completion is 2009-08.
What conditions does trial NCT00466388 study?
This clinical trial studies the following conditions: Xerostomia.
What interventions are being tested in trial NCT00466388?
The interventions under investigation include: Cevimeline (DRUG).
Who is sponsoring clinical trial NCT00466388?
This trial is sponsored by American Academy of Otolaryngology-Head and Neck Surgery Foundation, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00466388 being conducted?
This trial has 7 study locations across Colorado, Illinois, Kansas, Kentucky, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Xerostomia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00466388's enrollment target sits among peer trials
54 7th of 13 higher than 7 of 13 other Xerostomia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Xerostomia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
d-Limonene +Radiation +PlatinumBasedChemo for Xerostomia Prevention in LocallyAdvanced HNSCC
RECRUITING · Phase 1
-
Dose-Escalation Trial of Mesenchymal Stromal Cells in Patients With Medical Xerostomia
RECRUITING · Phase 1
-
Study Transplanting Bone Marrow Cells Into Salivary Glands to Treat Dry Mouth Caused by Radiation Therapy
ACTIVE NOT RECRUITING · Phase 1
-
Effect of Whitening Agent With Emulsion Gel in Saliva and Halitosis
ACTIVE NOT RECRUITING · NA
-
Observational Study of Dental Outcomes in Head and Neck Cancer Patients
ACTIVE NOT RECRUITING
-
Dry Mouth Toothpaste Study - Comparing Two Toothpastes With Arginine
ACTIVE NOT RECRUITING · Phase 3
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01269853 · 54 participants · Phase 1
Repeated Super-selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Relapsed GBM and AA
- NCT02390752 · 54 participants · Phase 1
Phase I Trial of TURALIO(R) (Pexidartinib, PLX3397) in Children and Young Adults With Refractory Leukemias and Refractory Solid Tumors Including Neurofibromatosis Type 1 (NF1) Associated Plexiform Neurofibromas (PN) and Tenosynovial Giant Cell Tumor ...
- NCT02991248 · 54 participants · NA
Improve Dynamic Lateral Balance of Humans With SCI
- NCT02993900 · 54 participants · NA
Image-Guided Gynecologic Brachytherapy
Similar registry start date
- NCT05988463 · started 2027-01-01 · Phase 1
Dose-Escalation Study of Artesunate Patients With IPF
- NCT07219706 · started 2026-12-10 · NA
Dietary Fiber and Time Restricted Eating
- NCT02831335 · started 2026-12-01
Technical Development of Multi-Parametric Renocerebral MRI
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia