Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Unipolar Depression: later-stage trial registry
4 of 9 indexed Unipolar Depression trials are currently recruiting, with more weight in Phase 3-4.
Corpus placement: #1,916 of 28,707 conditions by registered trial count.
9 US clinical trials · 4 currently recruiting · #1,916 of 28,707 conditions by registered trial count
Unipolar Depression: 9 US clinical trials tracked, 4 recruiting.
Unipolar Depression is the subject of 9 registered US clinical trials on ClinicalTrials.gov, 4 of them currently open to new participants. 4 are in Phase 3-4 (later-stage) and 2 in Phase 1-2 (earlier-stage). The most active sponsor is Soterix Medical, running 2 of these trials.
Enrollment posture brief
Registry condition unipolar-depression
OPEN 4 | RECR 44% | LATE 4 | EARLY 2 | RANK #1916 | SPON 2
Volume-matched condition peers
Nearest open-share peer: Acute Ischemic Stroke (44% recruiting · 27 trials)
Unipolar Depression lists 4 open slots (44% of 9 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Unipolar Depression on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Unipolar Depression is recruiting below its size-band peers.
4 of 9 indexed trials (44.4%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Unipolar Depression research.
Soterix Medical accounts for 2 of 9 trials (22.2%). 7 distinct sponsors appear on at least one study for this condition label.
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Most Unipolar Depression trials plan to enrol fewer than 100 people.
Median target enrolment is 50 among the 9 trials that report a genuine target (sentinel values excluded). 6 of those (66.7%) plan for fewer than 100 participants.
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Unipolar Depression research is mostly interventional.
8 interventional and 1 observational studies make up this index (88.9% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
9 total, page 1 of 1
RNA Editing as a Biomarker of Antidepressant Response in Unipolar and Bipolar Depression (EDIT-ANDRE)
Mayo Clinic
NCT07266545
Effect of Tao Calligraphy Meditation and Energized Water on Depression
Sha Research Foundation
NCT06934330
Transcranial Direct Current Stimulation for Depression
Soterix Medical
NCT07042217
Psilocybin-Assisted Therapy for the Treatment of Major Depressive Disorder in Patients With Non-Small Cell Lung Cancer
Alan Davis
NCT07216404
Triiodothyronine (T3) Supplementation in the Treatment of Bipolar and Unipolar Depression.
Hadassah Medical Organization
NCT00158990
Mechanism of Action of Electroconvulsive Therapy
Massachusetts General Hospital
NCT04059952
The BIO-K Study: A Single-Arm, Open-Label, Biomarker Development Clinical Trial of Ketamine for Non-Psychotic Unipolar Major Depression and Bipolar I or II Depression.
Mayo Clinic
NCT03156504
Home-administered tDCS for Treatment of Depression
Soterix Medical
NCT04781127
The Effects of Wellbutrin (Bupropion) on Residual and Cognitive Symptoms in SSRI-treated Depression
Mclean Hospital
NCT00125957
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 1 |
| Phase 3 | 2 |
| Phase 4 | 2 |
Top Sponsors
Named interventions
Most-linked intervention names on Unipolar Depression records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Unipolar Depression trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Unipolar Depression page
9 registered trials, 4 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 4 Unipolar Depression trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Soterix Medical sponsors the most Unipolar Depression trials on record, review their full trial history before evaluating a specific study. See Soterix Medical's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Unipolar Depression condition card totals 9 registered trials; most-linked intervention Soterix Medical mini-CT tDCS stimulator; top US site state Ohio. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.