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TBTC Study 24: Intermittent Treatment of TB With Isoniazid Resistance or Intolerance
NCT00023374 · View on ClinicalTrials.gov ↗
Study Summary
This study is a prospective, open-label, nonrandomized trial using a largely-intermittent, six-month tuberculosis treatment regimen among patients who will not receive isoniazid due to the presence of initial isoniazid resistance or intolerance. Subjects are enrolled after resistance or intolerance to isoniazid has been documented, and are treated for a total of six months (nine months if baseline chest x-ray shows cavitation and 2-month sputum culture is positive) with twice weekly or thrice weekly rifampin, ethambutol, and pyrazinamide.
Conditions Studied
Interventions
- DRUG Ethambutol
- DRUG Rifampin
- DRUG Pyrazinamide
- DRUG REZ
Study Locations (20)
New York
- New York University School of Medicine — New York
- Columbia University/Presbyterian Medical Center — New York
- Harlem Hospital Center — New York
Texas
- University of North Texas Health Science Center — Fort Worth
- Thomas Street Clinic — Houston
- Audi L. Murphy VA Hospital — San Antonio
California
- LA County/USC Medical Center — Los Angeles
- University of California, San Francisco — San Francisco
Illinois
- Chicago VA Medical Center (Lakeside) — Chicago
- Hines VA Medical Center — Hines
North Carolina
- Carolinas Medical Center — Charlotte
- Duke University Medical Center — Durham
Arkansas
- Central Arkansas Veterans Health System — Little Rock
Colorado
- Denver Department of Public Health and Hospitals — Denver
District of Columbia
- Washington, D.C. VAMC — Washington D.C.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 98 participants |
| Start Date | 2000-08 |
| Est. Completion | 2010-12 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00023374
The ClinicalTrials.gov registry entry for NCT00023374 describes a study currently listed as completed. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 98 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Centers for Disease Control and Prevention, which has 42 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Tuberculosis appearing as the primary indexed condition, and to 4 interventions — of which Ethambutol is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT00023374 reports 20 study locations spanning 13 distinct geographic areas — top geographies include New York, Texas, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT00023374 about?
NCT00023374 is a clinical study titled "TBTC Study 24: Intermittent Treatment of TB With Isoniazid Resistance or Intolerance". This study is a prospective, open-label, nonrandomized trial using a largely-intermittent, six-month tuberculosis treatment regimen among patients who will not receive isoniazid due to the presence of initial isoniazid resistance or intolerance. Subjects are enrolled after resistance or intolerance ...
What is the current status of trial NCT00023374?
This trial is currently completed. It is a NA study. The enrollment target is 98 participants. The study started on 2000-08. Estimated completion is 2010-12.
What conditions does trial NCT00023374 study?
This clinical trial studies the following conditions: Tuberculosis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT00023374?
The interventions under investigation include: Ethambutol (DRUG), Rifampin (DRUG), Pyrazinamide (DRUG), REZ (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT00023374?
This trial is sponsored by Centers for Disease Control and Prevention, which has 42 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT00023374 being conducted?
This trial has 20 study locations across Arkansas, California, Colorado, District of Columbia, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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