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NCT05526911 · ClinicalTrials.gov registry record · Phase 1
A Phase 1, Drug-Drug Interaction Study of TBAJ-876 in Healthy Adults
A Phase 1 study of Tuberculosis and Pulmonary Disease, sponsored by Global Alliance for TB Drug Development.
- Completed
- Registry status
- Phase 1
- Development phase
- 28
- Enrollment target
- 1
- Study location
NCT05526911: Completed Phase 1 study of Tuberculosis and Pulmonary Disease, sponsored by Global Alliance for TB Drug Development.
NCT05526911 is a Phase 1 study of Tuberculosis and Pulmonary Disease that has completed, run by Global Alliance for TB Drug Development. The registered enrollment target is 28 participants, below the 933-participant average among 29 other Tuberculosis trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05526911, a Phase 1 study of Tuberculosis and Pulmonary Disease, has completed, sponsored by Global Alliance for TB Drug Development.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 28 participants
- Enrollment target
- 1
- Study location
Study Summary
A Phase 1, Drug-Drug Interaction Study to Evaluate the Safety, Tolerability, and the Induction Potential of TBAJ-876 on CYP3A4 and P-glycoprotein and the Inhibition Potential of TBAJ-876 on P-glycoprotein in Healthy Adult Subjects
Primary Outcome
Geometric mean and range of midazolam's area under the (plasma concentration vs. time) curve when co-administered with TBAJ-876 versus when administered alone.
Conditions Studied
Interventions
- DRUG Midazolam
- DRUG Digoxin
- DRUG TBAJ-876
Study Locations (1)
New Jersey
- TKL Research, Inc. - Fair Lawn
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 28 participants |
| Start Date | 2022-06-30 |
| Est. Completion | 2022-09-26 |
| Phase | Phase 1 |
What the finished NCT05526911 record still lists
NCT05526911 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 28 participants, a relatively small participant target, below the 933-participant average among 29 other Tuberculosis trials with a reported enrollment target (97% lower).
The record links to 7 conditions, with Tuberculosis appearing as the primary indexed condition, and to 3 interventions - of which Midazolam is the first listed.
NCT05526911 reports a single indexed study location in New Jersey.
Frequently Asked Questions
What is clinical trial NCT05526911 about?
NCT05526911 is a clinical study titled "A Phase 1, Drug-Drug Interaction Study of TBAJ-876 in Healthy Adults". A Phase 1, Drug-Drug Interaction Study to Evaluate the Safety, Tolerability, and the Induction Potential of TBAJ-876 on CYP3A4 and P-glycoprotein and the Inhibition Potential of TBAJ-876 on P-glycoprotein in Healthy Adult Subjects
What is the current status of trial NCT05526911?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 28 participants. The study started on 2022-06-30. Estimated completion is 2022-09-26.
What conditions does trial NCT05526911 study?
This clinical trial studies the following conditions: Tuberculosis, Pulmonary Disease, Tuberculosis, Pulmonary, Multi-drug Resistant Tuberculosis, Drug Sensitive Tuberculosis.
What interventions are being tested in trial NCT05526911?
The interventions under investigation include: Midazolam (DRUG), Digoxin (DRUG), TBAJ-876 (DRUG).
Who is sponsoring clinical trial NCT05526911?
This trial is sponsored by Global Alliance for TB Drug Development, which has 13 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05526911 being conducted?
This trial has 1 study location across New Jersey. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Tuberculosis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05526911's enrollment target sits among peer trials
28 27th of 29 higher than 2 of 29 other Tuberculosis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Tuberculosis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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