Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Total Knee Replacement: early-phase trial registry
3 of 10 indexed Total Knee Replacement trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #1,724 of 28,707 conditions by registered trial count.
10 US clinical trials · 3 currently recruiting · #1,724 of 28,707 conditions by registered trial count
Total Knee Replacement: 10 US clinical trials tracked, 3 recruiting.
Total Knee Replacement is the subject of 10 registered US clinical trials on ClinicalTrials.gov, 3 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 3 in Phase 1-2 (earlier-stage). The most active sponsor is Yale University, running 2 of these trials.
Enrollment posture brief
Registry condition total-knee-replacement
OPEN 3 | RECR 30% | LATE 1 | EARLY 3 | RANK #1724 | SPON 2
Volume-matched condition peers
Nearest open-share peer: Adrenocortical Carcinoma (30% recruiting · 10 trials)
Total Knee Replacement lists 3 open slots (30% of 10 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Total Knee Replacement on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
-
Total Knee Replacement is recruiting below its size-band peers.
3 of 10 indexed trials (30%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
-
One sponsor concentrates Total Knee Replacement research.
Yale University accounts for 2 of 10 trials (20%). 8 distinct sponsors appear on at least one study for this condition label.
-
Typical Total Knee Replacement enrolment sits around 130 participants.
Median target enrolment is 130 among the 10 trials that report a genuine target (sentinel values excluded). 5 of those (50%) plan for fewer than 100 participants.
-
Total Knee Replacement research is mostly interventional.
8 interventional and 2 observational studies make up this index (80% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
10 total, page 1 of 1
Yale Steroid Enhanced Versus Exparel Nerveblock TKA RCT Study
Yale University
NCT05279092
An Open Label Data Collection Study of My Connect Post-Op, a Post-Operative Communication Tool
Concentra AI
NCT07120191
Yale Steroid Enhanced Versus Exparel Nerveblock TKA Part 2
Yale University
NCT05736549
Knee Arthroplasty Activity Trial
Brigham and Women's Hospital
NCT04107649
Adductor Canal Block
OrthoCarolina Research Institute
NCT04513145
Metal Ion Concentrations After Total Knee Arthroplasty
Mayo Clinic
NCT06447922
X-3 Polyethylene Survival Outcomes Study
Mayo Clinic
NCT00493792
Antibiotic Elution in Total Knee Arthroplasty
Washington University School of Medicine
NCT03928522
Mindfulness Meditation Intervention Study
Hospital for Special Surgery, New York
NCT06180486
Study Comparing GAP-Flex to CPM Therapy in Treatment of TKR
Xeras Medical Technologies
NCT02670499
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 3 |
| Phase 4 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Total Knee Replacement records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Total Knee Replacement trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Total Knee Replacement page
10 registered trials, 3 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 3 Total Knee Replacement trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Yale University sponsors the most Total Knee Replacement trials on record, review their full trial history before evaluating a specific study. See Yale University's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Total Knee Replacement condition card totals 10 registered trials; most-linked intervention Bupivacaine -Dexamethasone Sodium Phosphate-Methylprednisolone Acetate; top US site state New York. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.