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ClinicalTrials.gov 12 recruiting now later-stage tilt

Tobacco Use Cessation: later-stage trial registry

12 of 37 indexed Tobacco Use Cessation trials are currently recruiting, with more weight in Phase 3-4.

Corpus placement: #406 of 28,707 conditions by registered trial count.

37 US clinical trials · 12 currently recruiting · #406 of 28,707 conditions by registered trial count

Tobacco Use Cessation: 37 US clinical trials tracked, 12 recruiting.

Tobacco Use Cessation is the subject of 37 registered US clinical trials on ClinicalTrials.gov, 12 of them currently open to new participants. 7 are in Phase 3-4 (later-stage) and 4 in Phase 1-2 (earlier-stage). The most active sponsor is Washington University School of Medicine, running 3 of these trials.

Enrollment posture brief

Registry condition tobacco-use-cessation

OPEN 12 | RECR 32% | LATE 7 | EARLY 4 | RANK #406 | SPON 3

Nearest open-share peer: Graft Vs Host Disease (32% recruiting · 37 trials)

Biliary Tract Cancer64.9%Breastfeeding45.9%Tobacco Use Cessation (this)32%Chronic Obstructive Pulmonar29.7%Burns24.3%
Open-enrollment share among volume-matched conditions near Tobacco Use Cessation

Tobacco Use Cessation lists 12 open slots (32% of 37 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Tobacco Use Cessation on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Tobacco Use Cessation is recruiting below its size-band peers.

    12 of 37 indexed trials (32.4%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. Sponsorship of Tobacco Use Cessation trials is spread across many organizations.

    Washington University School of Medicine accounts for 3 of 37 trials (8.1%). 29 distinct sponsors appear on at least one study for this condition label.

  3. Typical Tobacco Use Cessation enrolment sits around 204 participants.

    Median target enrolment is 204 among the 37 trials that report a genuine target (sentinel values excluded). 8 of those (21.6%) plan for fewer than 100 participants.

  4. Tobacco Use Cessation research is mostly interventional.

    36 interventional and 1 observational studies make up this index (97.3% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 11Phase 23Phase 32Phase 45

Open and recent trials

37 total, page 1 of 1

RECRUITING NA 5,000 participants

CONNECT Cancer Survivors With Tobacco Treatment

Washington University School of Medicine

NCT07020273

RECRUITING NA 3,000 participants

Mi QUIT CARE (Mile Square QUIT Community-Access-Referral-Expansion)

University of Illinois at Chicago

NCT04827420

RECRUITING NA 1,560 participants

Reach Through Equitable Implementation in Utah

University of Utah

NCT06881069

RECRUITING NA 1,332 participants

Comparative Effectiveness of Mobile Health Smoking Cessation Approaches Among Underserved Patients in Primary Care

University of Florida

NCT05415761

RECRUITING Phase 4 608 participants

Smoking Cessation Program in the Construction Sector

University of Miami

NCT06098144

RECRUITING Phase 3 200 participants

Cannabis-Tobacco Co-Use Treatment Study

Medical University of South Carolina

NCT06883162

RECRUITING Phase 4 150 participants

Extended Intervention for Tobacco Use (EXIT) for People Experiencing Homelessness

University of California, San Francisco

NCT07148232

RECRUITING NA 120 participants

Development of a Smoking Cessation Video Series

Wayne State University

NCT06443294

RECRUITING NA 105 participants

Integrating CHWs Into Prenatal Care for Maternal Smoking Cessation

Loma Linda University

NCT06438549

RECRUITING NA 75 participants

Comprehensive Tobacco Cessation for Cancer Patients and Survivors

Virginia Commonwealth University

NCT05805722

RECRUITING Phase 1 50 participants

Oral Cannabidiol for Tobacco Cessation

Johns Hopkins University

NCT05445804

RECRUITING NA 20 participants

Trauma-Informed Care for Smoking Cessation for Pregnancy

University of California, San Francisco

NCT07129590

ACTIVE NOT RECRUITING 5,212 participants

Ask Advise Connect (AAC) Harris Heath CPRIT

M.D. Anderson Cancer Center

NCT01788787

ACTIVE NOT RECRUITING NA 2,220 participants

Cessation Clinical Trial

Truth Initiative

NCT06806098

ACTIVE NOT RECRUITING NA 700 participants

A Pragmatic Trial of Chronic Disease Approaches to Ameliorate Tobacco Related Cardiovascular Disease Health Disparities

University of Minnesota

NCT05671380

ACTIVE NOT RECRUITING NA 432 participants

Development of UP2UTobacco for High School Youth

University of Virginia

NCT05396911

ACTIVE NOT RECRUITING Phase 4 204 participants

Reward Sensitivity and Pharmacotherapy for Smoking Cessation

M.D. Anderson Cancer Center

NCT02162849

ACTIVE NOT RECRUITING NA 100 participants

Feasibility of Delivering VergeRx at FQHCs

University of Virginia

NCT06161675

COMPLETED Phase 2 2,177 participants

Tobacco Quitlines:Adjunct to Dental Office Tobacco Intervention

Oregon Research Institute

NCT00384254

COMPLETED NA 1,973 participants

Interventions to Help More Low-income Smokers Quit

Washington University School of Medicine

NCT04311983

COMPLETED NA 1,944 participants

Helping Poor Smokers Quit

Washington University School of Medicine

NCT03194958

COMPLETED NA 1,318 participants

Quit and Win Contests to Improve Smoking Cessation Among College Students

University of Minnesota

NCT01096108

COMPLETED NA 1,102 participants

Disseminating an Evidence-based Tobacco Control Intervention for School Teachers in India

Glorian Sorensen

NCT05346991

COMPLETED NA 400 participants

Telephone Counseling for Snuff Users

HealthPartners Institute

NCT00265681

COMPLETED Phase 4 323 participants

A Smart Approach to Treating Tobacco Use Disorder in Persons Living With HIV

Yale University

NCT04490057

COMPLETED NA 236 participants

Quit and Fit: Teen Smoking Cessation

West Virginia University

NCT01242657

COMPLETED Phase 3 232 participants

Tobacco Tactics Website for Operating Engineers

University of Michigan

NCT01124110

COMPLETED NA 201 participants

Tobacco Cessation Via Doctors of Chiropractic

Oregon Research Institute

NCT00386945

COMPLETED Phase 2 172 participants

Effectiveness of Bupropion for Treating Nicotine Dependence in Young People

National Institute on Drug Abuse (NIDA)

NCT00129272

COMPLETED NA 165 participants

A Facebook Intervention for Young Sexual and Gender Minority Smokers

University of California, San Francisco

NCT03259360

COMPLETED NA 158 participants

Improving Adherence to Smoking Cessation Medication Among PLWHA

NYU Langone Health

NCT01898195

COMPLETED NA 149 participants

Evaluating a Web-Based Cardiovascular Disease Risk Factor Reduction Program Among American Indians

Black Hills Center for American Indian Health

NCT00608387

COMPLETED NA 61 participants

Connecting Alaska Native People to Quit Smoking

Mayo Clinic

NCT03645941

COMPLETED Phase 2 49 participants

Preloading With Nicotine Replacement Therapy in HIV-positive Smokers to Improve Self-Efficacy and Quit Attempts

Brown University

NCT04994444

COMPLETED Phase 4 35 participants

Engagement With an Adaptive Mobile Health Smoking Cessation Intervention

Massachusetts General Hospital

NCT04020718

COMPLETED NA 35 participants

Feasibility of a Culturally-Specific Video Text Cessation Intervention With AA Quitline Callers

Case Comprehensive Cancer Center

NCT03927976

COMPLETED NA 32 participants

Pilot Trial of Using SmokeBeat to Monitor and Increase Smoking Abstinence in Pregnant Women

University of Pennsylvania

NCT03209557

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 3
Phase 3 2
Phase 4 5

Named interventions

Most-linked intervention names on Tobacco Use Cessation records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Varenicline Drug
3 trials
Bupropion-SR Drug
1 trials
Smoke Free Home Behavioral
1 trials
Chronic disease management Web-based software Behavioral
1 trials
Brief counseling (Ask, Advise, Arrange) Behavioral
1 trials
SmartWatch SmokeBeat Application Other
1 trials
Phone counseling and written materials Behavioral
1 trials
Varenicline or bupropion Drug
1 trials

US sites by state

Facility locations filed on Tobacco Use Cessation trials. A trial with sites in several states counts in each.

Minnesota 4 trials
California 4 trials
Virginia 3 trials
Texas 3 trials
Missouri 3 trials
New York 2 trials
Michigan 2 trials
Massachusetts 2 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Tobacco Use Cessation page

37 registered trials, 12 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Tobacco Use Cessation condition card totals 37 registered trials; most-linked intervention Varenicline; top US site state Minnesota. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.