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2026 data Public-data reference. official source

Tobacco Use Cessation

Open-data reference.

37 US clinical trials · 12 currently recruiting

Active & Recent Trials

RECRUITING NA 5,000 participants

CONNECT Cancer Survivors With Tobacco Treatment

Washington University School of Medicine

NCT07020273

RECRUITING NA 3,000 participants

Mi QUIT CARE (Mile Square QUIT Community-Access-Referral-Expansion)

University of Illinois at Chicago

NCT04827420

RECRUITING NA 1,560 participants

Reach Through Equitable Implementation in Utah

University of Utah

NCT06881069

RECRUITING NA 1,332 participants

Comparative Effectiveness of Mobile Health Smoking Cessation Approaches Among Underserved Patients in Primary Care

University of Florida

NCT05415761

RECRUITING Phase 4 608 participants

Smoking Cessation Program in the Construction Sector

University of Miami

NCT06098144

RECRUITING Phase 3 200 participants

Cannabis-Tobacco Co-Use Treatment Study

Medical University of South Carolina

NCT06883162

RECRUITING Phase 4 150 participants

Extended Intervention for Tobacco Use (EXIT) for People Experiencing Homelessness

University of California, San Francis

NCT07148232

RECRUITING NA 120 participants

Development of a Smoking Cessation Video Series

Wayne State University

NCT06443294

RECRUITING NA 105 participants

Integrating CHWs Into Prenatal Care for Maternal Smoking Cessation

Loma Linda University

NCT06438549

RECRUITING NA 75 participants

Comprehensive Tobacco Cessation for Cancer Patients and Survivors

Virginia Commonwealth University

NCT05805722

RECRUITING Phase 1 50 participants

Oral Cannabidiol for Tobacco Cessation

Johns Hopkins University

NCT05445804

RECRUITING NA 20 participants

Trauma-Informed Care for Smoking Cessation for Pregnancy

University of California, San Francis

NCT07129590

ACTIVE NOT RECRUITING 5,212 participants

Ask Advise Connect (AAC) Harris Heath CPRIT

M.D. Anderson Cancer Center

NCT01788787

ACTIVE NOT RECRUITING NA 2,220 participants

Cessation Clinical Trial

Truth Initiative

NCT06806098

ACTIVE NOT RECRUITING NA 700 participants

A Pragmatic Trial of Chronic Disease Approaches to Ameliorate Tobacco Related Cardiovascular Disease Health Disparities

University of Minnesota

NCT05671380

ACTIVE NOT RECRUITING NA 432 participants

Development of UP2UTobacco for High School Youth

University of Virginia

NCT05396911

ACTIVE NOT RECRUITING Phase 4 204 participants

Reward Sensitivity and Pharmacotherapy for Smoking Cessation

M.D. Anderson Cancer Center

NCT02162849

ACTIVE NOT RECRUITING NA 100 participants

Feasibility of Delivering VergeRx at FQHCs

University of Virginia

NCT06161675

COMPLETED Phase 2 2,177 participants

Tobacco Quitlines:Adjunct to Dental Office Tobacco Intervention

Oregon Research Institute

NCT00384254

COMPLETED NA 1,973 participants

Interventions to Help More Low-income Smokers Quit

Washington University School of Medicine

NCT04311983

COMPLETED NA 1,944 participants

Helping Poor Smokers Quit

Washington University School of Medicine

NCT03194958

COMPLETED NA 1,318 participants

Quit and Win Contests to Improve Smoking Cessation Among College Students

University of Minnesota

NCT01096108

COMPLETED NA 1,102 participants

Disseminating an Evidence-based Tobacco Control Intervention for School Teachers in India

Glorian Sorensen

NCT05346991

COMPLETED NA 400 participants

Telephone Counseling for Snuff Users

HealthPartners Institute

NCT00265681

COMPLETED Phase 4 323 participants

A Smart Approach to Treating Tobacco Use Disorder in Persons Living With HIV

Yale University

NCT04490057

COMPLETED NA 236 participants

Quit and Fit: Teen Smoking Cessation

West Virginia University

NCT01242657

COMPLETED Phase 3 232 participants

Tobacco Tactics Website for Operating Engineers

University of Michigan

NCT01124110

COMPLETED NA 201 participants

Tobacco Cessation Via Doctors of Chiropractic

Oregon Research Institute

NCT00386945

COMPLETED Phase 2 172 participants

Effectiveness of Bupropion for Treating Nicotine Dependence in Young People

National Institute on Drug Abuse (NIDA)

NCT00129272

COMPLETED NA 165 participants

A Facebook Intervention for Young Sexual and Gender Minority Smokers

University of California, San Francis

NCT03259360

COMPLETED NA 158 participants

Improving Adherence to Smoking Cessation Medication Among PLWHA

NYU Langone Health

NCT01898195

COMPLETED NA 149 participants

Evaluating a Web-Based Cardiovascular Disease Risk Factor Reduction Program Among American Indians

Black Hills Center for American Indian Health

NCT00608387

COMPLETED NA 61 participants

Connecting Alaska Native People to Quit Smoking

Mayo Clinic

NCT03645941

COMPLETED Phase 2 49 participants

Preloading With Nicotine Replacement Therapy in HIV-positive Smokers to Improve Self-Efficacy and Quit Attempts

Brown University

NCT04994444

COMPLETED Phase 4 35 participants

Engagement With an Adaptive Mobile Health Smoking Cessation Intervention

Massachusetts General Hospital

NCT04020718

COMPLETED NA 35 participants

Feasibility of a Culturally-Specific Video Text Cessation Intervention With AA Quitline Callers

Case Comprehensive Cancer Center

NCT03927976

COMPLETED NA 32 participants

Pilot Trial of Using SmokeBeat to Monitor and Increase Smoking Abstinence in Pregnant Women

University of Pennsylvania

NCT03209557

Phase Distribution

PhaseTrial count
Early Phase 1 1
Phase 2 3
Phase 3 2
Phase 4 5

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Tobacco Use Cessation Trial Landscape

ClinicalTrials.gov lists 37 US studies indexed under Tobacco Use Cessation, and 12 of those are currently open to recruitment — roughly 32% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Tobacco Use Cessation shows 7 late-stage studies (Phase 3 and Phase 4 combined) alongside 4 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Tobacco Use Cessation is led by Washington University School of Medicine with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 37 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Tobacco Use Cessation?

PlainTrial tracks 37 US clinical trials for Tobacco Use Cessation, of which 12 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Tobacco Use Cessation?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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