Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05275101 · ClinicalTrials.gov registry record · NA
Neural Mechanisms and Predictors of an Ultra-Brief Suicide Prevention Strategy
A NA study of Suicide, sponsored by Ohio State University.
- Active
- Registry status
- NA
- Development phase
- 191
- Enrollment target
- 1
- Study location
NCT05275101: Active NA study of Suicide, sponsored by Ohio State University.
NCT05275101 is a NA study of Suicide that is active but no longer recruiting, run by Ohio State University. The registered enrollment target is 191 participants, below the 6,988-participant average among 92 other Suicide trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05275101, a NA study of Suicide, is active but no longer recruiting, sponsored by Ohio State University.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 191 participants
- Enrollment target
- 1
- Study location
Study Summary
The current study is a clinical trial, meaning a research study in which human subjects are prospectively assigned to one or more interventions to evaluate the effects of those interventions on health-related behavioral outcomes. Specifically, male and female adults with current suicidal intent will be randomly assigned to receive either a 1-hour session of crisis response planning (CRP) or a 1-hour session of standard crisis risk management (Treatment as Usual). The effects of both conditions on changes in emotion regulation, behavioral inhibition, stress reactivity, and suicide risk will be evaluated post-intervention and at six-month follow-up. Additional assessments of changes in mood and suicidality will be collected daily during the first 10-days following intervention, and then monthly for a duration of six months. A cohort of healthy controls is included in the study but are not randomized to either treatment condition. The investigators hypothesize the following: 1) A single session of CRP will acutely change suicide risk and 2) Individuals who receive CRP will show sustained improvements in measures of suicidality when compared to individuals who received the Treatment as Usual intervention.
Primary Outcome
Task-induced activity in frontolimbic neural circuits measured with fMRI. Core regions of interest are: ventral prefrontal cortex, dorsal prefrontal cortex, inferior frontal gyrus, insula, and dorsal anterior cingulate cortex.
Conditions Studied
Interventions
- BEHAVIORAL Crisis Response Planning
- BEHAVIORAL Crisis Risk Counseling
Study Locations (1)
Ohio
- Ohio State University - Columbus
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 191 participants |
| Start Date | 2021-07-28 |
| Est. Completion | 2026-04-01 |
| Phase | NA |
What the registry record for NCT05275101 still lists
NCT05275101 is an interventional study that assigns participants to a tested intervention. The registered 191 participants enrollment target is mid-sized for trials with a published cap, below the 6,988-participant average among 92 other Suicide trials with a reported enrollment target (97% lower).
The record links to 1 condition, with Suicide appearing as the primary indexed condition, and to 2 interventions - of which Crisis Response Planning is the first listed.
NCT05275101 reports a single indexed study location in Ohio.
Frequently Asked Questions
What is clinical trial NCT05275101 about?
NCT05275101 is a clinical study titled "Neural Mechanisms and Predictors of an Ultra-Brief Suicide Prevention Strategy". The current study is a clinical trial, meaning a research study in which human subjects are prospectively assigned to one or more interventions to evaluate the effects of those interventions on health-related behavioral outcomes. Specifically, male and female adults with current suicidal intent will...
What is the current status of trial NCT05275101?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 191 participants. The study started on 2021-07-28. Estimated completion is 2026-04-01.
What conditions does trial NCT05275101 study?
This clinical trial studies the following conditions: Suicide.
What interventions are being tested in trial NCT05275101?
The interventions under investigation include: Crisis Response Planning (BEHAVIORAL), Crisis Risk Counseling (BEHAVIORAL).
Who is sponsoring clinical trial NCT05275101?
This trial is sponsored by Ohio State University, which has 552 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05275101 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Suicide
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05275101's enrollment target sits among peer trials
191 34th of 92 higher than 59 of 92 other Suicide trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Suicide trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Reaching Out to Distressed Medical Residents, Fellows and Faculty
RECRUITING · NA
-
Randomized Clinical Trial of Supplementing Brief Psychotherapy With a Mobile App
RECRUITING · NA
-
Reducing Suicide Risk Among Aging Caregivers of Persons With AD/ADRD
RECRUITING · NA
-
Functional Connectivity Alterations in Suicidal Patients Among Opioid Users
RECRUITING · NA
-
Suicide Specific Rumination in Veterans
RECRUITING · NA
-
Real-time Examination of Skills and Coping Use in Teen's Everyday Lives
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT04621435 · 191 participants · Phase 1
Imaging of Solid Tumors Using FAP-2286
- NCT06810544 · 191 participants · Phase 1
Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss
- NCT01492972 · 192 participants · Phase 3
Hypo-fractionated Radiation Therapy With or Without Androgen Suppression for Intermediate Risk Prostate Cancer
- NCT01973881 · 192 participants
Quantitative MRI for Myelofibrosis
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI