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Sjogren's Syndrome clinical trials
7 of 21 indexed Sjogren's Syndrome trials are currently recruiting.
21 US clinical trials · 7 currently recruiting
Sjogren's Syndrome is the subject of 21 registered US clinical trials on ClinicalTrials.gov, 7 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 10 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Dental and Craniofacial Research (NIDCR), running 6 of these trials.
The research picture
Sjogren's Syndrome has 21 registered US clinical trials, 7 of them open to new participants right now, about 33% of the total.
- 7
- recruiting participants now
- 33%
- of trials open to enrollment
- 3
- in Phase 3–4 (later-stage)
- 6
- top sponsor: National Institute of Dental and Craniofacial Research (NIDCR)
Active & Recent Trials
21 total, page 1 of 1
Characterization of Diseases With Salivary Gland Involvement
National Institute of Dental and Craniofacial Research (NIDCR)
NCT02327884
Maternal Autoimmune Disease Research Alliance (MADRA) Registry
Duke University
NCT03276923
Rheumatology Diet Study
University of Central Florida
NCT06339957
The Pathogenesis and Natural History of Sjogren's Disease
National Institute of Dental and Craniofacial Research (NIDCR)
NCT01425892
Creating Health Course Study for People With Rheumatological Conditions
Terry L. Wahls
NCT07180537
Safety of Tofacitinib, an Oral Janus Kinase Inhibitor, in Primary Sjogren Disease
National Institute of Dental and Craniofacial Research (NIDCR)
NCT07281456
A Study of CLN-978, a Subcutaneously Administered CD19-directed T Cell Engager, in Subjects With Sjogren's Disease
Cullinan Therapeutics
NCT07041099
Nipocalimab in Moderate to Severe Sjogren's Disease
Janssen Research & Development
NCT06741969
A Study to Evaluate the Efficacy and Safety of Dazodalibep in Participants With Sjögren's Syndrome (SS) With Moderate-to-severe Systemic Disease Activity
Amgen
NCT06104124
A Randomized, Double-blind 2-arm, Followed by an Open-label 1-arm, NEPTUNUS Extension Study to Assess the Long-term Safety and Efficacy of Ianalumab in Patients With Sjogrens Syndrome.
Novartis Pharmaceuticals
NCT05985915
A Phase 2 Study to Investigate Efficacy and Safety of HZN-1116 in Participants With Sjogren's Syndrome
Amgen
NCT06312020
Safety of Tofacitinib, an Oral Janus Kinase Inhibitor, in Primary Sjogren's Syndrome
National Institute of Dental and Craniofacial Research (NIDCR)
NCT04496960
The Research Registry for Neonatal Lupus
NYU Langone Health
NCT00074373
A Study to Assess the Efficacy of RO5459072 in Participants With Primary Sjogren's Syndrome
Hoffmann-La Roche
NCT02701985
TrueTear in Sjogren's Disease Patients
University of Pennsylvania
NCT03719885
Treatment of Dry Eye Syndrome With Cyclosporin A Eye Drops
National Eye Institute (NEI)
NCT00001731
Etanercept Therapy for Sjogren's Syndrome
National Institute of Dental and Craniofacial Research (NIDCR)
NCT00001954
Evaluation of the Role of the Autonomic Nervous System in Sj(SqrRoot)(Delta)Gren s Syndrome
National Institute of Dental and Craniofacial Research (NIDCR)
NCT00565526
An Evaluation of the Impact of a Single Dose of P-552 on Oral Mucosal Wetness
Parion Sciences
NCT01369589
Omalizumab for Lupus
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
NCT01716312
Anti-CD20 Antibody Therapy for Sjogren's Syndrome
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00101829
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 5 |
| Phase 2 | 5 |
| Phase 3 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Sjogren's Syndrome Trial Landscape
21 indexed Sjogren's Syndrome studies · 7 recruiting (33%).
Phase mix: 3 late (III/IV) vs 10 early (I/II).
Top sponsor: National Institute of Dental and Craniofacial Research (NIDCR) (6 trials), 9 others listed. 21 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Sjogren's Syndrome?
PlainTrial tracks 21 US clinical trials for Sjogren's Syndrome, of which 7 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Sjogren's Syndrome?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.