Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Sjogren's Syndrome: early-phase trial registry
7 of 21 indexed Sjogren's Syndrome trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #797 of 28,707 conditions by registered trial count.
21 US clinical trials · 7 currently recruiting · #797 of 28,707 conditions by registered trial count
Sjogren's Syndrome: 21 US clinical trials tracked, 7 recruiting.
Sjogren's Syndrome is the subject of 21 registered US clinical trials on ClinicalTrials.gov, 7 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 10 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Dental and Craniofacial Research (NIDCR), running 6 of these trials.
Enrollment posture brief
Registry condition sjogrens-syndrome
OPEN 7 | RECR 33% | LATE 3 | EARLY 10 | RANK #797 | SPON 6
Volume-matched condition peers
Nearest open-share peer: Adherence, Treatment (33% recruiting · 6 trials)
Sjogren's Syndrome lists 7 open slots (33% of 21 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Sjogren's Syndrome on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Sjogren's Syndrome is recruiting below its size-band peers.
7 of 21 indexed trials (33.3%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Sjogren's Syndrome research.
National Institute of Dental and Craniofacial Research (NIDCR) accounts for 6 of 21 trials (28.6%). 15 distinct sponsors appear on at least one study for this condition label.
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Typical Sjogren's Syndrome enrolment sits around 75 participants.
Median target enrolment is 75 among the 21 trials that report a genuine target (sentinel values excluded). 11 of those (52.4%) plan for fewer than 100 participants.
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Sjogren's Syndrome research is mostly interventional.
15 interventional and 6 observational studies make up this index (71.4% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
21 total, page 1 of 1
Characterization of Diseases With Salivary Gland Involvement
National Institute of Dental and Craniofacial Research (NIDCR)
NCT02327884
Maternal Autoimmune Disease Research Alliance (MADRA) Registry
Duke University
NCT03276923
Rheumatology Diet Study
University of Central Florida
NCT06339957
The Pathogenesis and Natural History of Sjogren's Disease
National Institute of Dental and Craniofacial Research (NIDCR)
NCT01425892
Creating Health Course Study for People With Rheumatological Conditions
Terry L. Wahls
NCT07180537
Safety of Tofacitinib, an Oral Janus Kinase Inhibitor, in Primary Sjogren Disease
National Institute of Dental and Craniofacial Research (NIDCR)
NCT07281456
A Study of CLN-978, a Subcutaneously Administered CD19-directed T Cell Engager, in Subjects With Sjogren's Disease
Cullinan Therapeutics
NCT07041099
Nipocalimab in Moderate to Severe Sjogren's Disease
Janssen Research & Development
NCT06741969
A Study to Evaluate the Efficacy and Safety of Dazodalibep in Participants With Sjögren's Syndrome (SS) With Moderate-to-severe Systemic Disease Activity
Amgen
NCT06104124
A Randomized, Double-blind 2-arm, Followed by an Open-label 1-arm, NEPTUNUS Extension Study to Assess the Long-term Safety and Efficacy of Ianalumab in Patients With Sjogrens Syndrome.
Novartis Pharmaceuticals
NCT05985915
A Phase 2 Study to Investigate Efficacy and Safety of HZN-1116 in Participants With Sjogren's Syndrome
Amgen
NCT06312020
Safety of Tofacitinib, an Oral Janus Kinase Inhibitor, in Primary Sjogren's Syndrome
National Institute of Dental and Craniofacial Research (NIDCR)
NCT04496960
The Research Registry for Neonatal Lupus
NYU Langone Health
NCT00074373
A Study to Assess the Efficacy of RO5459072 in Participants With Primary Sjogren's Syndrome
Hoffmann-La Roche
NCT02701985
TrueTear in Sjogren's Disease Patients
University of Pennsylvania
NCT03719885
Treatment of Dry Eye Syndrome With Cyclosporin A Eye Drops
National Eye Institute (NEI)
NCT00001731
Etanercept Therapy for Sjogren's Syndrome
National Institute of Dental and Craniofacial Research (NIDCR)
NCT00001954
Evaluation of the Role of the Autonomic Nervous System in Sj(SqrRoot)(Delta)Gren s Syndrome
National Institute of Dental and Craniofacial Research (NIDCR)
NCT00565526
An Evaluation of the Impact of a Single Dose of P-552 on Oral Mucosal Wetness
Parion Sciences
NCT01369589
Omalizumab for Lupus
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
NCT01716312
Anti-CD20 Antibody Therapy for Sjogren's Syndrome
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00101829
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 5 |
| Phase 2 | 5 |
| Phase 3 | 3 |
Top Sponsors
Named interventions
Most-linked intervention names on Sjogren's Syndrome records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Sjogren's Syndrome trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Sjogren's Syndrome page
21 registered trials, 7 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 7 Sjogren's Syndrome trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- National Institute of Dental and Craniofacial Research (NIDCR) sponsors the most Sjogren's Syndrome trials on record, review their full trial history before evaluating a specific study. See National Institute of Dental and Craniofacial Research (NIDCR)'s trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Sjogren's Syndrome condition card totals 21 registered trials; most-linked intervention Placebo; top US site state Maryland. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.