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ClinicalTrials.gov 7 recruiting now official registry

Sjogren's Syndrome clinical trials

7 of 21 indexed Sjogren's Syndrome trials are currently recruiting.

21 US clinical trials · 7 currently recruiting

Sjogren's Syndrome is the subject of 21 registered US clinical trials on ClinicalTrials.gov, 7 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 10 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Dental and Craniofacial Research (NIDCR), running 6 of these trials.

The research picture

Sjogren's Syndrome has 21 registered US clinical trials, 7 of them open to new participants right now, about 33% of the total.

7
recruiting participants now
33%
of trials open to enrollment
3
in Phase 3–4 (later-stage)
6
top sponsor: National Institute of Dental and Craniofacial Research (NIDCR)
Phase 15Phase 25Phase 33

Active & Recent Trials

21 total, page 1 of 1

RECRUITING 1,150 participants

Characterization of Diseases With Salivary Gland Involvement

National Institute of Dental and Craniofacial Research (NIDCR)

NCT02327884

RECRUITING 1,000 participants

Maternal Autoimmune Disease Research Alliance (MADRA) Registry

Duke University

NCT03276923

RECRUITING 500 participants

Rheumatology Diet Study

University of Central Florida

NCT06339957

RECRUITING 300 participants

The Pathogenesis and Natural History of Sjogren's Disease

National Institute of Dental and Craniofacial Research (NIDCR)

NCT01425892

RECRUITING NA 200 participants

Creating Health Course Study for People With Rheumatological Conditions

Terry L. Wahls

NCT07180537

RECRUITING Phase 2 60 participants

Safety of Tofacitinib, an Oral Janus Kinase Inhibitor, in Primary Sjogren Disease

National Institute of Dental and Craniofacial Research (NIDCR)

NCT07281456

RECRUITING Phase 1 36 participants

A Study of CLN-978, a Subcutaneously Administered CD19-directed T Cell Engager, in Subjects With Sjogren's Disease

Cullinan Therapeutics

NCT07041099

ACTIVE NOT RECRUITING Phase 3 655 participants

Nipocalimab in Moderate to Severe Sjogren's Disease

Janssen Research & Development

NCT06741969

ACTIVE NOT RECRUITING Phase 3 651 participants

A Study to Evaluate the Efficacy and Safety of Dazodalibep in Participants With Sjögren's Syndrome (SS) With Moderate-to-severe Systemic Disease Activity

Amgen

NCT06104124

ACTIVE NOT RECRUITING Phase 3 612 participants

A Randomized, Double-blind 2-arm, Followed by an Open-label 1-arm, NEPTUNUS Extension Study to Assess the Long-term Safety and Efficacy of Ianalumab in Patients With Sjogrens Syndrome.

Novartis Pharmaceuticals

NCT05985915

ACTIVE NOT RECRUITING Phase 2 209 participants

A Phase 2 Study to Investigate Efficacy and Safety of HZN-1116 in Participants With Sjogren's Syndrome

Amgen

NCT06312020

ACTIVE NOT RECRUITING Phase 1 23 participants

Safety of Tofacitinib, an Oral Janus Kinase Inhibitor, in Primary Sjogren's Syndrome

National Institute of Dental and Craniofacial Research (NIDCR)

NCT04496960

COMPLETED 100 participants

The Research Registry for Neonatal Lupus

NYU Langone Health

NCT00074373

COMPLETED Phase 2 75 participants

A Study to Assess the Efficacy of RO5459072 in Participants With Primary Sjogren's Syndrome

Hoffmann-La Roche

NCT02701985

COMPLETED NA 55 participants

TrueTear in Sjogren's Disease Patients

University of Pennsylvania

NCT03719885

COMPLETED Phase 2 30 participants

Treatment of Dry Eye Syndrome With Cyclosporin A Eye Drops

National Eye Institute (NEI)

NCT00001731

COMPLETED Phase 2 28 participants

Etanercept Therapy for Sjogren's Syndrome

National Institute of Dental and Craniofacial Research (NIDCR)

NCT00001954

COMPLETED 28 participants

Evaluation of the Role of the Autonomic Nervous System in Sj(SqrRoot)(Delta)Gren s Syndrome

National Institute of Dental and Craniofacial Research (NIDCR)

NCT00565526

COMPLETED Phase 1 24 participants

An Evaluation of the Impact of a Single Dose of P-552 on Oral Mucosal Wetness

Parion Sciences

NCT01369589

COMPLETED Phase 1 17 participants

Omalizumab for Lupus

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

NCT01716312

COMPLETED Phase 1 12 participants

Anti-CD20 Antibody Therapy for Sjogren's Syndrome

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00101829

Phase Distribution

PhaseTrial count
Phase 1 5
Phase 2 5
Phase 3 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Sjogren's Syndrome Trial Landscape

21 indexed Sjogren's Syndrome studies · 7 recruiting (33%).

Phase mix: 3 late (III/IV) vs 10 early (I/II).

Top sponsor: National Institute of Dental and Craniofacial Research (NIDCR) (6 trials), 9 others listed. 21 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Sjogren's Syndrome?

PlainTrial tracks 21 US clinical trials for Sjogren's Syndrome, of which 7 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Sjogren's Syndrome?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.