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Severe Hypertriglyceridemia clinical trials
2 of 9 indexed Severe Hypertriglyceridemia trials are currently recruiting.
9 US clinical trials · 2 currently recruiting
Severe Hypertriglyceridemia is the subject of 9 registered US clinical trials on ClinicalTrials.gov, 2 of them currently open to new participants. 7 are in Phase 3-4 (later-stage) and 2 in Phase 1-2 (earlier-stage). The most active sponsor is Arrowhead Pharmaceuticals, running 3 of these trials.
The research picture
Severe Hypertriglyceridemia has 9 registered US clinical trials, 2 of them open to new participants right now, about 22% of the total.
- 2
- recruiting participants now
- 22%
- of trials open to enrollment
- 7
- in Phase 3–4 (later-stage)
- 3
- top sponsor: Arrowhead Pharmaceuticals
Active & Recent Trials
9 total, page 1 of 1
Study of Plozasiran in Adults With Severe Hypertriglyceridemia at Risk of Acute Pancreatitis
Arrowhead Pharmaceuticals
NCT06880770
A Study of Solbinsiran (LY3561774) in Participants With Severe Hypertriglyceridemia
Eli Lilly and Company
NCT07269210
CORE-OLE: A Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Participants With Severe Hypertriglyceridemia (SHTG)
Ionis Pharmaceuticals
NCT05681351
Study of Plozasiran (ARO-APOC3) in Adults With Severe Hypertriglyceridemia
Arrowhead Pharmaceuticals
NCT06347003
To Evaluate the Efficacy and Safety of Pegozafermin in Subjects With Severe Hypertriglyceridemia
89bio
NCT05852431
Study of Plozasiran in Adults With Severe Hypertriglyceridemia
Arrowhead Pharmaceuticals
NCT06347016
Study to Evaluate the Efficacy and Safety of K-877 in Adult Patients With Fasting High Triglyceride Levels and Normal Renal Function
Kowa Research Institute
NCT03001817
A Study of Olezarsen Administered Subcutaneously to Participants With Severe Hypertriglyceridemia
Ionis Pharmaceuticals
NCT05552326
Epanova® Compared to Lovaza® In a Pharmacokinetic, Single-dose, Evaluation
AstraZeneca
NCT01208961
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 2 |
| Phase 3 | 7 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Severe Hypertriglyceridemia Trial Landscape
9 indexed Severe Hypertriglyceridemia studies · 2 recruiting (22%).
Phase mix: 7 late (III/IV) vs 2 early (I/II).
Top sponsor: Arrowhead Pharmaceuticals (3 trials), 5 others listed. 9 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Severe Hypertriglyceridemia?
PlainTrial tracks 9 US clinical trials for Severe Hypertriglyceridemia, of which 2 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Severe Hypertriglyceridemia?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.