Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Severe Hypertriglyceridemia: later-stage trial registry
2 of 9 indexed Severe Hypertriglyceridemia trials are currently recruiting, with more weight in Phase 3-4.
Corpus placement: #1,916 of 28,707 conditions by registered trial count.
9 US clinical trials · 2 currently recruiting · #1,916 of 28,707 conditions by registered trial count
Severe Hypertriglyceridemia: 9 US clinical trials tracked, 2 recruiting.
Severe Hypertriglyceridemia is the subject of 9 registered US clinical trials on ClinicalTrials.gov, 2 of them currently open to new participants. 7 are in Phase 3-4 (later-stage) and 2 in Phase 1-2 (earlier-stage). The most active sponsor is Arrowhead Pharmaceuticals, running 3 of these trials.
Enrollment posture brief
Registry condition severe-hypertriglyceridemia
OPEN 2 | RECR 22% | LATE 7 | EARLY 2 | RANK #1916 | SPON 3
Volume-matched condition peers
Nearest open-share peer: Acne (22% recruiting · 27 trials)
Severe Hypertriglyceridemia lists 2 open slots (22% of 9 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Severe Hypertriglyceridemia on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Severe Hypertriglyceridemia is recruiting below its size-band peers.
2 of 9 indexed trials (22.2%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Severe Hypertriglyceridemia research.
Arrowhead Pharmaceuticals accounts for 3 of 9 trials (33.3%). 6 distinct sponsors appear on at least one study for this condition label.
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Typical Severe Hypertriglyceridemia enrolment sits around 360 participants.
Median target enrolment is 360 among the 9 trials that report a genuine target (sentinel values excluded). 2 of those (22.2%) plan for fewer than 100 participants.
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Severe Hypertriglyceridemia research is mostly interventional.
9 interventional and 0 observational studies make up this index (100% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
9 total, page 1 of 1
Study of Plozasiran in Adults With Severe Hypertriglyceridemia at Risk of Acute Pancreatitis
Arrowhead Pharmaceuticals
NCT06880770
A Study of Solbinsiran (LY3561774) in Participants With Severe Hypertriglyceridemia
Eli Lilly and Company
NCT07269210
CORE-OLE: A Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Participants With Severe Hypertriglyceridemia (SHTG)
Ionis Pharmaceuticals
NCT05681351
Study of Plozasiran (ARO-APOC3) in Adults With Severe Hypertriglyceridemia
Arrowhead Pharmaceuticals
NCT06347003
To Evaluate the Efficacy and Safety of Pegozafermin in Subjects With Severe Hypertriglyceridemia
89bio
NCT05852431
Study of Plozasiran in Adults With Severe Hypertriglyceridemia
Arrowhead Pharmaceuticals
NCT06347016
Study to Evaluate the Efficacy and Safety of K-877 in Adult Patients With Fasting High Triglyceride Levels and Normal Renal Function
Kowa Research Institute
NCT03001817
A Study of Olezarsen Administered Subcutaneously to Participants With Severe Hypertriglyceridemia
Ionis Pharmaceuticals
NCT05552326
Epanova® Compared to Lovaza® In a Pharmacokinetic, Single-dose, Evaluation
AstraZeneca
NCT01208961
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 2 |
| Phase 3 | 7 |
Top Sponsors
Named interventions
Most-linked intervention names on Severe Hypertriglyceridemia records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Severe Hypertriglyceridemia trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Severe Hypertriglyceridemia page
9 registered trials, 2 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 2 Severe Hypertriglyceridemia trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Arrowhead Pharmaceuticals sponsors the most Severe Hypertriglyceridemia trials on record, review their full trial history before evaluating a specific study. See Arrowhead Pharmaceuticals's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Severe Hypertriglyceridemia condition card totals 9 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.