Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
Study of Plozasiran in Adults With Severe Hypertriglyceridemia
NCT06347016 · View on ClinicalTrials.gov ↗
Study Summary
This Phase 3 study will evaluate the safety and efficacy of plozasiran injection (ARO-APOC3) in adult participants with severe hypertriglyceridemia (SHTG). After providing informed consent eligible participants will be randomized to receive 4 doses (once every 3 months) of plozasiran or placebo, and be evaluated for efficacy and safety. After Month 12, eligible participants will be offered an opportunity to continue in an optional open-label extension under a separate protocol.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Plozasiran Injection
Study Locations (20)
California
- Research Site 3 — Beverly Hills
- Research Site 4 — Canoga Park
- Research Site 5 — Huntington Beach
- Research Site 6 — Lincoln
- Research Site 7 — Long Beach
- Research Site 8 — Oxnard
Florida
- Research Site 9 — Clearwater
- Research Site 10 — North Miami
- Research Site 11 — Sarasota
Indiana
- Research Site 14 — Elkhart
- Research Site 15 — Indianapolis
- Research Site 16 — South Bend
Alabama
- Research Site 1 — Birmingham
- Research Site 2 — Mobile
Georgia
- Research Site 12 — Lawrenceville
- Research Site 13 — Sugar Hill
Kansas
- Research Site 17 — Overland Park
- Research Site 18 — Topeka
Louisiana
- Research Site 19 — Metairie
Maryland
- Research Site 20 — Annapolis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 311 participants |
| Start Date | 2024-07-23 |
| Est. Completion | 2026-09 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06347016
The ClinicalTrials.gov registry entry for NCT06347016 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 311 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Arrowhead Pharmaceuticals, which has 11 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Severe Hypertriglyceridemia appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06347016 reports 20 study locations spanning 8 distinct geographic areas — top geographies include California, Florida, Indiana. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06347016 about?
NCT06347016 is a clinical study titled "Study of Plozasiran in Adults With Severe Hypertriglyceridemia". This Phase 3 study will evaluate the safety and efficacy of plozasiran injection (ARO-APOC3) in adult participants with severe hypertriglyceridemia (SHTG). After providing informed consent eligible participants will be randomized to receive 4 doses (once every 3 months) of plozasiran or placebo, and...
What is the current status of trial NCT06347016?
This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 311 participants. The study started on 2024-07-23. Estimated completion is 2026-09.
What conditions does trial NCT06347016 study?
This clinical trial studies the following conditions: Severe Hypertriglyceridemia. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06347016?
The interventions under investigation include: Placebo (DRUG), Plozasiran Injection (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06347016?
This trial is sponsored by Arrowhead Pharmaceuticals, which has 11 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06347016 being conducted?
This trial has 20 study locations across Alabama, California, Florida, Georgia, Indiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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