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ClinicalTrials.gov 5 recruiting now official registry

SARS-CoV-2 clinical trials

5 of 29 indexed SARS-CoV-2 trials are currently recruiting.

29 US clinical trials · 5 currently recruiting

SARS-CoV-2 is the subject of 29 registered US clinical trials on ClinicalTrials.gov, 5 of them currently open to new participants. 6 are in Phase 3-4 (later-stage) and 8 in Phase 1-2 (earlier-stage). The most active sponsor is ModernaTX, running 5 of these trials.

The research picture

SARS-CoV-2 has 29 registered US clinical trials, 5 of them open to new participants right now, about 17% of the total.

5
recruiting participants now
17%
of trials open to enrollment
6
in Phase 3–4 (later-stage)
5
top sponsor: ModernaTX
Phase 16Phase 22Phase 34Phase 42

Active & Recent Trials

29 total, page 1 of 1

RECRUITING Phase 4 30,000 participants

A Study to Evaluate the Efficacy and Safety of mRNA-1283 and mRNA-1273 in Participants 50 to 64 Years of Age Without High-Risk Conditions for Severe Coronavirus Disease 2019 (COVID-19)

ModernaTX

NCT07266558

RECRUITING Phase 4 1,094 participants

A Study to Investigate the Immunogenicity and Safety of mRNA COVID-19 Variant-containing Vaccine Formulations

ModernaTX

NCT06585241

RECRUITING 800 participants

Determinants of SARS (Severe Acute Respiratory Syndrome)-COV2 (COVID-19) Persistence After Convalescence

Columbia University

NCT04448145

RECRUITING NA 500 participants

Improving the Collaborative Health of Minority COVID-19 Survivor and Carepartner Dyads

University of South Carolina

NCT05370014

RECRUITING Phase 1 40 participants

Kisspeptin to Quantify GnRH Neuronal Function in Health and Disease

Stephanie B. Seminara, MD

NCT07224490

ACTIVE NOT RECRUITING 201 participants

COVID-19 Biorepository

University of Kansas Medical Center

NCT04568148

ACTIVE NOT RECRUITING 1 participants

Use and Effectiveness of COVID-19 Vaccines Using State Vaccine Registries and Insurance Claims Data

Pfizer

NCT05876377

COMPLETED Phase 3 32,450 participants

Phase III Double-blind, Placebo-controlled Study of AZD1222 for the Prevention of COVID-19 in Adults

AstraZeneca

NCT04516746

COMPLETED Phase 3 30,415 participants

A Study to Evaluate Efficacy, Safety, and Immunogenicity of mRNA-1273 Vaccine in Adults Aged 18 Years and Older to Prevent COVID-19

ModernaTX

NCT04470427

COMPLETED 2,824 participants

Epidemiology, Immunology and Clinical Characteristics of COVID-19 (EPIC3)

VA Office of Research and Development

NCT05764083

COMPLETED Phase 1 1,758 participants

A Study of mRNA-based Influenza and SARS-CoV-2 (COVID-19) Multi-component Vaccines in Healthy Adults

ModernaTX

NCT05827926

COMPLETED Phase 2 1,225 participants

Convalescent Plasma to Limit SARS-CoV-2 Associated Complications

Johns Hopkins University

NCT04373460

COMPLETED 602 participants

Network-Targeted Strategies for Efficient Community SARS-CoV-2 (COVID-19) Sampling

Duke University

NCT04437706

COMPLETED Phase 3 593 participants

Inpatient Treatment of COVID-19 With Anti-Coronavirus Immunoglobulin (ITAC)

University of Minnesota

NCT04546581

COMPLETED 472 participants

Monitoring Serologic Response to Severe Acute Respiratory Syndrome-2 (SARS-COV-2)/COVID-19 in Children

Connecticut Children's Medical Center

NCT04838834

COMPLETED 412 participants

COVID-19 in Patients With HIV

University of Missouri-Columbia

NCT04333953

COMPLETED 372 participants

Asymptomatic SARS-CoV-2 Detection in Children

University of Calgary

NCT04853316

COMPLETED NA 300 participants

Seroprevalence of SARS CoV 2 Antibodies in Previously Undiagnosed Healthcare Workers

Mayo Clinic

NCT04383587

COMPLETED Early Phase 1 245 participants

SHIELD Study: Using Naso-oropharyngeal Antiseptic Decolonization to Reduce COVID-19 Viral Shedding

University of Wisconsin, Madison

NCT04478019

COMPLETED Phase 3 234 participants

A Study to Evaluate Safety and Immunogenicity of mRNA-1273 Vaccine to Prevent COVID-19 in Adult Organ Transplant Recipients and in Healthy Adult Participants

ModernaTX

NCT04860297

COMPLETED 205 participants

Comparison of EPM-IX to Currently Used Specimen Transportation and Extraction Devices ( CGI-EPM-IX )

Convergent Genomics

NCT05281692

COMPLETED NA 200 participants

A Clinical Evaluation of COVID-19 Rapid Point of Care Antigen Tests

E25Bio

NCT04568356

COMPLETED 140 participants

Clinical Evaluation of a Point-of-Care (POC), COVID-19 Rapid Antigen Test (CoviDx™)

Lumos Diagnostics

NCT04750629

COMPLETED 129 participants

Assessment of Exam Findings in Coronavirus Disease 2019 (COVID-19) With Point-of-Care Ultrasonography (POCUS)

University of Minnesota

NCT04339998

COMPLETED NA 129 participants

NOWDx Test for the Detection of Antibodies to COVID-19

NOWDiagnostics

NCT04690413

COMPLETED Phase 1 99 participants

Safety, Reactogenicity, and Immunogenicity Trial of CV2CoV mRNA Vaccine Against SARS-CoV-2 in Seropositive Adult Participants

GlaxoSmithKline

NCT05260437

COMPLETED Phase 1 51 participants

Study to Investigate the Safety, Tolerability, and Pharmacokinetics of GB-0669 in Healthy Adult Participants

Generate Biomedicines

NCT07050511

COMPLETED Phase 1 35 participants

A Live Recombinant Newcastle Disease Virus-vectored COVID-19 Vaccine Phase 1 Study.

Sean Liu

NCT05181709

COMPLETED Phase 2 29 participants

Convalescent Plasma for Treatment of COVID-19 Patients With Pneumonia

University of Virginia

NCT04374565

Phase Distribution

PhaseTrial count
Phase 1 6
Phase 2 2
Phase 3 4
Phase 4 2

Top Sponsors

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the SARS-CoV-2 Trial Landscape

29 indexed SARS-CoV-2 studies · 5 recruiting (17%).

Phase mix: 6 late (III/IV) vs 8 early (I/II).

Top sponsor: ModernaTX (5 trials), 9 others listed. 29 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for SARS-CoV-2?

PlainTrial tracks 29 US clinical trials for SARS-CoV-2, of which 5 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for SARS-CoV-2?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.