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SARS-CoV-2 clinical trials
5 of 29 indexed SARS-CoV-2 trials are currently recruiting.
29 US clinical trials · 5 currently recruiting
SARS-CoV-2 is the subject of 29 registered US clinical trials on ClinicalTrials.gov, 5 of them currently open to new participants. 6 are in Phase 3-4 (later-stage) and 8 in Phase 1-2 (earlier-stage). The most active sponsor is ModernaTX, running 5 of these trials.
The research picture
SARS-CoV-2 has 29 registered US clinical trials, 5 of them open to new participants right now, about 17% of the total.
- 5
- recruiting participants now
- 17%
- of trials open to enrollment
- 6
- in Phase 3–4 (later-stage)
- 5
- top sponsor: ModernaTX
Active & Recent Trials
29 total, page 1 of 1
A Study to Evaluate the Efficacy and Safety of mRNA-1283 and mRNA-1273 in Participants 50 to 64 Years of Age Without High-Risk Conditions for Severe Coronavirus Disease 2019 (COVID-19)
ModernaTX
NCT07266558
A Study to Investigate the Immunogenicity and Safety of mRNA COVID-19 Variant-containing Vaccine Formulations
ModernaTX
NCT06585241
Determinants of SARS (Severe Acute Respiratory Syndrome)-COV2 (COVID-19) Persistence After Convalescence
Columbia University
NCT04448145
Improving the Collaborative Health of Minority COVID-19 Survivor and Carepartner Dyads
University of South Carolina
NCT05370014
Kisspeptin to Quantify GnRH Neuronal Function in Health and Disease
Stephanie B. Seminara, MD
NCT07224490
COVID-19 Biorepository
University of Kansas Medical Center
NCT04568148
Use and Effectiveness of COVID-19 Vaccines Using State Vaccine Registries and Insurance Claims Data
Pfizer
NCT05876377
Phase III Double-blind, Placebo-controlled Study of AZD1222 for the Prevention of COVID-19 in Adults
AstraZeneca
NCT04516746
A Study to Evaluate Efficacy, Safety, and Immunogenicity of mRNA-1273 Vaccine in Adults Aged 18 Years and Older to Prevent COVID-19
ModernaTX
NCT04470427
Epidemiology, Immunology and Clinical Characteristics of COVID-19 (EPIC3)
VA Office of Research and Development
NCT05764083
A Study of mRNA-based Influenza and SARS-CoV-2 (COVID-19) Multi-component Vaccines in Healthy Adults
ModernaTX
NCT05827926
Convalescent Plasma to Limit SARS-CoV-2 Associated Complications
Johns Hopkins University
NCT04373460
Network-Targeted Strategies for Efficient Community SARS-CoV-2 (COVID-19) Sampling
Duke University
NCT04437706
Inpatient Treatment of COVID-19 With Anti-Coronavirus Immunoglobulin (ITAC)
University of Minnesota
NCT04546581
Monitoring Serologic Response to Severe Acute Respiratory Syndrome-2 (SARS-COV-2)/COVID-19 in Children
Connecticut Children's Medical Center
NCT04838834
COVID-19 in Patients With HIV
University of Missouri-Columbia
NCT04333953
Asymptomatic SARS-CoV-2 Detection in Children
University of Calgary
NCT04853316
Seroprevalence of SARS CoV 2 Antibodies in Previously Undiagnosed Healthcare Workers
Mayo Clinic
NCT04383587
SHIELD Study: Using Naso-oropharyngeal Antiseptic Decolonization to Reduce COVID-19 Viral Shedding
University of Wisconsin, Madison
NCT04478019
A Study to Evaluate Safety and Immunogenicity of mRNA-1273 Vaccine to Prevent COVID-19 in Adult Organ Transplant Recipients and in Healthy Adult Participants
ModernaTX
NCT04860297
Comparison of EPM-IX to Currently Used Specimen Transportation and Extraction Devices ( CGI-EPM-IX )
Convergent Genomics
NCT05281692
A Clinical Evaluation of COVID-19 Rapid Point of Care Antigen Tests
E25Bio
NCT04568356
Clinical Evaluation of a Point-of-Care (POC), COVID-19 Rapid Antigen Test (CoviDx™)
Lumos Diagnostics
NCT04750629
Assessment of Exam Findings in Coronavirus Disease 2019 (COVID-19) With Point-of-Care Ultrasonography (POCUS)
University of Minnesota
NCT04339998
NOWDx Test for the Detection of Antibodies to COVID-19
NOWDiagnostics
NCT04690413
Safety, Reactogenicity, and Immunogenicity Trial of CV2CoV mRNA Vaccine Against SARS-CoV-2 in Seropositive Adult Participants
GlaxoSmithKline
NCT05260437
Study to Investigate the Safety, Tolerability, and Pharmacokinetics of GB-0669 in Healthy Adult Participants
Generate Biomedicines
NCT07050511
A Live Recombinant Newcastle Disease Virus-vectored COVID-19 Vaccine Phase 1 Study.
Sean Liu
NCT05181709
Convalescent Plasma for Treatment of COVID-19 Patients With Pneumonia
University of Virginia
NCT04374565
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 6 |
| Phase 2 | 2 |
| Phase 3 | 4 |
| Phase 4 | 2 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the SARS-CoV-2 Trial Landscape
29 indexed SARS-CoV-2 studies · 5 recruiting (17%).
Phase mix: 6 late (III/IV) vs 8 early (I/II).
Top sponsor: ModernaTX (5 trials), 9 others listed. 29 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for SARS-CoV-2?
PlainTrial tracks 29 US clinical trials for SARS-CoV-2, of which 5 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for SARS-CoV-2?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.