Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
A Study of mRNA-based Influenza and SARS-CoV-2 (COVID-19) Multi-component Vaccines in Healthy Adults
NCT05827926 · View on ClinicalTrials.gov ↗
Study Summary
The study is divided into 2 parts: Part 1 and Part 2. The purpose of Part 1 of this study is to generate sufficient safety, reactogenicity, and immunogenicity data to enable selection of an mRNA-1083 vaccine composition and dose level to evaluate in a subsequent Phase 3 clinical trial in adults. The purpose of Part 2 of this study is to generate safety and immunogenicity data for additional mRNA-1083 compositions and dose levels in young adults ≥18 years and \<50 years of age.
Conditions Studied
Interventions
- BIOLOGICAL Influenza Vaccine 1
- BIOLOGICAL mRNA-1083.1
- BIOLOGICAL mRNA-1083.2
- BIOLOGICAL mRNA-1083.3
- BIOLOGICAL Investigational Influenza Vaccine 1
Study Locations (20)
Florida
- Accel Research Sites — DeLand
- CenExel — Hollywood
- Nature Coast Clinical Research — Inverness
- Jacksonville Center For Clinical Research — Jacksonville
- Accel Research Sites — Maitland
- Suncoast Research Group — Miami
California
- Benchmark Research — Colton
- Marvel Clinical Research — Huntington Beach
- Central Valley Research — Modesto
- Benchmark Research — Sacramento
Georgia
- Centricity Research — Columbus
- Accel Research Site — Decatur
- CenExel iResearch — Decatur
- Lifeline Primary Care — Lilburn
Illinois
- Koch Family Medicine — Morton
- Optimal Research — Peoria
- DM Clinical Research — River Forest
Arizona
- Chandler Clinical Trials — Chandler
Colorado
- Tekton Research — Longmont
Kansas
- Johnson County Clin-Trials — Lenexa
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,758 participants |
| Start Date | 2023-04-14 |
| Est. Completion | 2024-12-03 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05827926
The ClinicalTrials.gov registry entry for NCT05827926 describes a study currently listed as completed. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 1,758 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is ModernaTX, which has 67 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Influenza appearing as the primary indexed condition, and to 5 interventions — of which Influenza Vaccine 1 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05827926 reports 20 study locations spanning 7 distinct geographic areas — top geographies include Florida, California, Georgia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05827926 about?
NCT05827926 is a clinical study titled "A Study of mRNA-based Influenza and SARS-CoV-2 (COVID-19) Multi-component Vaccines in Healthy Adults". The study is divided into 2 parts: Part 1 and Part 2. The purpose of Part 1 of this study is to generate sufficient safety, reactogenicity, and immunogenicity data to enable selection of an mRNA-1083 vaccine composition and dose level to evaluate in a subsequent Phase 3 clinical trial in adults. Th...
What is the current status of trial NCT05827926?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 1,758 participants. The study started on 2023-04-14. Estimated completion is 2024-12-03.
What conditions does trial NCT05827926 study?
This clinical trial studies the following conditions: Influenza, SARS-CoV-2. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05827926?
The interventions under investigation include: Influenza Vaccine 1 (BIOLOGICAL), mRNA-1083.1 (BIOLOGICAL), mRNA-1083.2 (BIOLOGICAL), mRNA-1083.3 (BIOLOGICAL), Investigational Influenza Vaccine 1 (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05827926?
This trial is sponsored by ModernaTX, which has 67 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05827926 being conducted?
This trial has 20 study locations across Arizona, California, Colorado, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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