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NCT07224490 · ClinicalTrials.gov registry record · Phase 1
Kisspeptin to Quantify GnRH Neuronal Function in Health and Disease
A Phase 1 study of SARS-CoV-2 and Reproductive Disorder, sponsored by Stephanie B. Seminara, MD.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 40
- Enrollment target
- 1
- Study location
NCT07224490: Recruiting Phase 1 study of SARS-CoV-2 and Reproductive Disorder, sponsored by Stephanie B. Seminara, MD.
NCT07224490 is a Phase 1 study of SARS-CoV-2 and Reproductive Disorder that is actively recruiting participants, run by Stephanie B. Seminara, MD. The registered enrollment target is 40 participants, below the 3,453-participant average among 34 other SARS-CoV-2 trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07224490, a Phase 1 study of SARS-CoV-2 and Reproductive Disorder, is actively recruiting participants, sponsored by Stephanie B. Seminara, MD.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
The objective of this protocol is to use a case-control paradigm to compare the response to an intravenous administration of kisspeptin in individuals with and without post-covid-19 syndrome. The study subjects will receive a single bolus of kisspeptin. This study will utilize the technique of frequent blood sampling (q10 minutes) to provide detailed neuroendocrine characterization of endogenous LH secretion before and after kisspeptin administration. This frequency of blood sampling is required to define the features of LH pulses.
Primary Outcome
Difference between cases and controls of mean LH amplitude in response to kisspeptin
Conditions Studied
Interventions
- DRUG Kisspeptin 112-121
Study Locations (1)
Massachusetts
- Massachusetts General Hospital - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2026-03 |
| Est. Completion | 2030-05 |
| Phase | Phase 1 |
What NCT07224490 shows while recruiting
NCT07224490 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 3,453-participant average among 34 other SARS-CoV-2 trials with a reported enrollment target (99% lower).
The record links to 3 conditions, with SARS-CoV-2 appearing as the primary indexed condition, and to 1 intervention - of which Kisspeptin 112-121 is the first listed.
NCT07224490 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT07224490 about?
NCT07224490 is a clinical study titled "Kisspeptin to Quantify GnRH Neuronal Function in Health and Disease". The objective of this protocol is to use a case-control paradigm to compare the response to an intravenous administration of kisspeptin in individuals with and without post-covid-19 syndrome. The study subjects will receive a single bolus of kisspeptin. This study will utilize the technique of freq...
What is the current status of trial NCT07224490?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 40 participants. The study started on 2026-03. Estimated completion is 2030-05.
What conditions does trial NCT07224490 study?
This clinical trial studies the following conditions: SARS-CoV-2, Reproductive Disorder, Neurodegeneration.
What interventions are being tested in trial NCT07224490?
The interventions under investigation include: Kisspeptin 112-121 (DRUG).
Who is sponsoring clinical trial NCT07224490?
This trial is sponsored by Stephanie B. Seminara, MD, which has 11 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07224490 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for SARS-CoV-2
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07224490's enrollment target sits among peer trials
40 31st of 34 higher than 4 of 34 other SARS-CoV-2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other SARS-CoV-2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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