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NCT06789445 · ClinicalTrials.gov registry record · Phase 1
A Study to Investigate the Safety of OpCT-001 in Adults Who Have Primary Photoreceptor Disease (CLARICO)
A Phase 1 study of Retinal Degeneration and Cone-Rod Dystrophy, sponsored by BlueRock Therapeutics.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 54
- Enrollment target
- 3
- Study locations
NCT06789445 is a Phase 1 study of Retinal Degeneration and Cone-Rod Dystrophy that is actively recruiting participants, run by BlueRock Therapeutics. The registered enrollment target is 54 participants, below the 338-participant average among 17 other Retinal Degeneration trials with a reported enrollment target (84% lower). The trial reports 3 study locations across 3 states.
The verdict
NCT06789445, a Phase 1 study of Retinal Degeneration and Cone-Rod Dystrophy, is actively recruiting participants, sponsored by BlueRock Therapeutics.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 54 participants
- Enrollment target
- 3
- Study locations
Study Summary
Study OpCT-001-101 is a Phase 1/2a first-in-human, multisite, 2-part interventional study to evaluate the safety, tolerability, and the effect on clinical outcomes of OpCT-001 in up to approximately 54 adults with primary photoreceptor (PR) disease. Phase 1 will focus on safety and features a dose-escalation design. Phase 2 is designed to gather additional safety data and assess the effect of OpCT-001 on measures of visual function, functional vision, and anatomic measures of engraftment in different clinical subgroups.
Conditions Studied
Interventions
- BIOLOGICAL OpCT-001
Study Locations (3)
Florida
- University of Miami, Bascom Palmer Eye Institute - Miami
Texas
- Retina Foundation of the Southwest - Dallas
Wisconsin
- University of Wisconsin - Madison
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 54 participants |
| Start Date | 2025-03-10 |
| Est. Completion | 2030-10 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06789445
The ClinicalTrials.gov registry entry for NCT06789445 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 54 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 338-participant average among 17 other Retinal Degeneration trials with a reported enrollment target (84% lower). The listed sponsor is BlueRock Therapeutics, which has 4 total studies on file at ClinicalTrials.gov.
The record links to 9 conditions, with Retinal Degeneration appearing as the primary indexed condition, and to 1 intervention - of which OpCT-001 is the first listed.
NCT06789445 reports 3 study locations spanning 3 distinct geographic areas - top geographies include Florida, Texas, Wisconsin.
Frequently Asked Questions
What is clinical trial NCT06789445 about?
NCT06789445 is a clinical study titled "A Study to Investigate the Safety of OpCT-001 in Adults Who Have Primary Photoreceptor Disease (CLARICO)". Study OpCT-001-101 is a Phase 1/2a first-in-human, multisite, 2-part interventional study to evaluate the safety, tolerability, and the effect on clinical outcomes of OpCT-001 in up to approximately 54 adults with primary photoreceptor (PR) disease. Phase 1 will focus on safety and features a dose-e...
What is the current status of trial NCT06789445?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 54 participants. The study started on 2025-03-10. Estimated completion is 2030-10.
What conditions does trial NCT06789445 study?
This clinical trial studies the following conditions: Retinal Degeneration, Cone-Rod Dystrophy, Retinitis Pigmentosa (RP), Rod Cone Dystrophy, Primary Photoreceptor Disease.
What interventions are being tested in trial NCT06789445?
The interventions under investigation include: OpCT-001 (BIOLOGICAL).
Who is sponsoring clinical trial NCT06789445?
This trial is sponsored by BlueRock Therapeutics, which has 4 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06789445 being conducted?
This trial has 3 study locations across Florida, Texas, Wisconsin. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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