Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Recurrent Lung Non-Small Cell Carcinoma

Open-data reference.

31 US clinical trials · 9 currently recruiting

Active & Recent Trials

RECRUITING Phase 2 378 participants

Adding the Immunotherapy Drug Cemiplimab to Usual Treatment for People With Advanced Non-Small Cell Lung Cancer Who Had Previous Treatment With Platinum Chemotherapy and Immunotherapy (An Expanded Lung-MAP Treatment Trial)

SWOG Cancer Research Network

NCT06616584

RECRUITING NA 80 participants

PET/CT Changes During Chemoimmunotherapy and Radiation Therapy in Patients With Stage IV Non-small Cell Lung Cancer

University of Washington

NCT04151940

RECRUITING Phase 2 66 participants

Comparing Combinations of Targeted Drugs for Advanced Non-Small Cell Lung Cancer That Has EGFR and MET Gene Changes (A Lung-MAP Treatment Trial)

SWOG Cancer Research Network

NCT05642572

RECRUITING Phase 2 56 participants

Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)

SWOG Cancer Research Network

NCT06031688

RECRUITING Phase 2 46 participants

Testing Osimertinib as a Treatment for Lung Cancers With an EGFR Exon 20 Change

National Cancer Institute (NCI)

NCT03191149

RECRUITING Phase 1 30 participants

PBF-1129 and Nivolumab for the Treatment of Recurrent or Metastatic Non-Small Cell Lung Cancer

Dwight Owen

NCT05234307

RECRUITING Phase 2 30 participants

SX-682 With Pembrolizumab for the Treatment of Metastatic or Recurrent Stage IIIC or IV Non-Small Cell Lung Cancer

University of Washington

NCT05570825

RECRUITING Phase 1 24 participants

Vismodegib and Atezolizumab for the Treatment of Recurrent or Metastatic Non-Small Cell Lung Cancer

Dwight Owen

NCT06616623

RECRUITING Phase 1 10 participants

MOv19-BBz CAR T Cells in FRa+ Cancers

University of Pennsylvania

NCT07116057

ACTIVE NOT RECRUITING Phase 3 838 participants

Ramucirumab Plus Pembrolizumab vs Usual Care for Treatment of Stage IV or Recurrent Non-Small Cell Lung Cancer Following Immunotherapy, Pragmatica-Lung Study

SWOG Cancer Research Network

NCT05633602

ACTIVE NOT RECRUITING Phase 3 660 participants

Testing the Addition of an Antibody to Standard Chemoradiation Followed by the Antibody for One Year to Standard Chemoradiation Followed by One Year of the Antibody in Patients With Unresectable Stage III Non-Small Cell Lung Cancer

National Cancer Institute (NCI)

NCT04092283

ACTIVE NOT RECRUITING Phase 2 173 participants

Osimertinib, Surgery, and Radiation Therapy in Treating Patients With Stage IIIB or IV Non-small Cell Lung Cancer With EGFR Mutations, NORTHSTAR Study

M.D. Anderson Cancer Center

NCT03410043

ACTIVE NOT RECRUITING Phase 1 146 participants

Image-Guided, Intensity-Modulated Photon or Proton Beam Radiation Therapy in Treating Patients With Stage II-IIIB Non-small Cell Lung Cancer

M.D. Anderson Cancer Center

NCT01629498

ACTIVE NOT RECRUITING Phase 2 140 participants

Stereotactic Body Radiation Therapy With or Without Nivolumab in Treating Patients With Stage I-IIA or Recurrent Non-small Cell Lung Cancer

M.D. Anderson Cancer Center

NCT03110978

ACTIVE NOT RECRUITING Phase 1 138 participants

Osimertinib and Necitumumab in Treating Patients With EGFR-Mutant Stage IV or Recurrent Non-small Cell Lung Cancer Who Have Progressed on a Previous EGFR Tyrosine Kinase Inhibitor

National Cancer Institute (NCI)

NCT02496663

ACTIVE NOT RECRUITING Phase 2 125 participants

Erlotinib Hydrochloride and Cabozantinib-s-Malate Alone or in Combination as Second or Third Line Therapy in Treating Patients With Stage IV Non-small Cell Lung Cancer

National Cancer Institute (NCI)

NCT01708954

ACTIVE NOT RECRUITING Phase 2 124 participants

Targeted Treatment for RET Fusion-Positive Advanced Non-Small Cell Lung Cancer (A LUNG-MAP Treatment Trial)

SWOG Cancer Research Network

NCT04268550

ACTIVE NOT RECRUITING Phase 2 101 participants

Testing the Effects of MK-3475 (Pembrolizumab) With or Without the Usual Chemotherapy Treatment for Patients 70 Years of Age and Older With Advanced Non-small Cell Lung Cancer

Alliance for Clinical Trials in Oncology

NCT04533451

ACTIVE NOT RECRUITING Phase 2 82 participants

Testing the Use of Combination Immunotherapy Treatment (N-803 [ALT-803] Plus Pembrolizumab) Against the Usual Treatment for Advanced Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial)

SWOG Cancer Research Network

NCT05096663

ACTIVE NOT RECRUITING Phase 2 60 participants

Trametinib and Docetaxel in Treating Patients With Recurrent or Stage IV KRAS Mutation Positive Non-small Cell Lung Cancer

National Cancer Institute (NCI)

NCT02642042

ACTIVE NOT RECRUITING Phase 2 51 participants

Atezolizumab and Cobimetinib in Treating Patients With Metastatic, Recurrent, or Refractory Non-small Cell Lung Cancer

National Cancer Institute (NCI)

NCT03600701

ACTIVE NOT RECRUITING Phase 1 37 participants

Trametinib and Pembrolizumab in Treating Patients With Recurrent Non-small Cell Lung Cancer That Is Metastatic, Unresectable, or Locally Advanced

M.D. Anderson Cancer Center

NCT03225664

ACTIVE NOT RECRUITING Phase 1 36 participants

Testing the Combination of MLN0128 (TAK-228) and AZD9291 in Advanced EGFR (Epidermal Growth Factor Receptor) Mutation Positive Non-small Cell Lung Cancer

National Cancer Institute (NCI)

NCT02503722

ACTIVE NOT RECRUITING Phase 1 35 participants

Local Consolidative Therapy and Brigatinib in Treating Patients With Stage IV or Recurrent Non-small Cell Lung Cancer

M.D. Anderson Cancer Center

NCT03707938

ACTIVE NOT RECRUITING Phase 1 34 participants

NBTXR3 and Radiation Therapy for the Treatment of Inoperable Recurrent Non-small Cell Lung Cancer

M.D. Anderson Cancer Center

NCT04505267

ACTIVE NOT RECRUITING Phase 1 22 participants

Testing of the Anti Cancer Drugs CB-839 HCl (Telaglenastat) and MLN0128 (Sapanisertib) in Advanced Stage Non-small Cell Lung Cancer

National Cancer Institute (NCI)

NCT04250545

ACTIVE NOT RECRUITING Phase 1 18 participants

All-Trans Retinoic Acid (ATRA) and Atezolizumab for the Treatment of Recurrent or Metastatic Non-Small Cell Lung Cancer

Dwight Owen

NCT04919369

ACTIVE NOT RECRUITING Phase 1 12 participants

Ensartinib, Carboplatin, Pemetrexed and Bevacizumab for the Treatment of Stage IIIC or IV or Recurrent ALK-Positive Non-small Cell Lung Cancer

M.D. Anderson Cancer Center

NCT04837716

ACTIVE NOT RECRUITING Phase 1 6 participants

Genetically Engineered Natural Killer (NK) Cells With or Without Atezolizumab for the Treatment of Non-small Cell Lung Cancer Previously Treated With PD-1 and/or PD-L1 Immune Checkpoint Inhibitors

University of California, Irvine

NCT05334329

ACTIVE NOT RECRUITING Phase 1 5 participants

Brigatinib and Bevacizumab for the Treatment of ALK-Rearranged Locally Advanced, Metastatic, or Recurrent NSCLC

City of Hope Medical Center

NCT04227028

COMPLETED Phase 1 11 participants

Erlotinib Hydrochloride and Onalespib Lactate in Treating Patients With Recurrent or Metastatic EGFR-Mutant Non-small Cell Lung Cancer

National Cancer Institute (NCI)

NCT02535338

Phase Distribution

PhaseTrial count
Early Phase 1 15
Phase 2 13
Phase 3 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Recurrent Lung Non-Small Cell Carcinoma Trial Landscape

ClinicalTrials.gov lists 31 US studies indexed under Recurrent Lung Non-Small Cell Carcinoma, and 9 of those are currently open to recruitment — roughly 29% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Recurrent Lung Non-Small Cell Carcinoma shows 2 late-stage studies (Phase 3 and Phase 4 combined) alongside 28 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Recurrent Lung Non-Small Cell Carcinoma is led by National Cancer Institute (NCI) with 9 indexed trials, alongside 8 other organizations in the top contributor list. The list on this page surfaces up to 31 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Recurrent Lung Non-Small Cell Carcinoma?

PlainTrial tracks 31 US clinical trials for Recurrent Lung Non-Small Cell Carcinoma, of which 9 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Recurrent Lung Non-Small Cell Carcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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