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NCT03191149 · ClinicalTrials.gov registry record · Phase 2
Testing Osimertinib as a Treatment for Lung Cancers With an EGFR Exon 20 Change
A Phase 2 study of Recurrent Lung Non-Small Cell Carcinoma and Advanced Lung Non-Small Cell Carcinoma, sponsored by National Cancer Institute (NCI).
- Recruiting
- Registry status
- Phase 2
- Development phase
- 46
- Enrollment target
- 20
- Study locations
NCT03191149 is a Phase 2 study of Recurrent Lung Non-Small Cell Carcinoma and Advanced Lung Non-Small Cell Carcinoma that is actively recruiting participants, run by National Cancer Institute (NCI). The registered enrollment target is 46 participants, below the 118-participant average among 30 other Recurrent Lung Non-Small Cell Carcinoma trials with a reported enrollment target (61% lower). The trial reports 20 study locations across 7 states.
The verdict
NCT03191149, a Phase 2 study of Recurrent Lung Non-Small Cell Carcinoma and Advanced Lung Non-Small Cell Carcinoma, is actively recruiting participants, sponsored by National Cancer Institute (NCI).
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 46 participants
- Enrollment target
- 20
- Study locations
Study Summary
This phase II trial studies how well osimertinib works in treating patients with non-small cell lung cancer with EGFR exon 20 insertion mutation that is stage IIIB-IV or has come back after a period of improvement (recurrent). Osimertinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Conditions Studied
Interventions
- PROCEDURE Biospecimen Collection
- PROCEDURE Magnetic Resonance Imaging
- PROCEDURE Echocardiography Test
- PROCEDURE Multigated Acquisition Scan
- PROCEDURE Computed Tomography with Contrast
Study Locations (20)
Alaska
- Anchorage Associates in Radiation Medicine - Anchorage
- Anchorage Radiation Therapy Center - Anchorage
- Alaska Breast Care and Surgery LLC - Anchorage
- Alaska Oncology and Hematology LLC - Anchorage
- Alaska Women's Cancer Care - Anchorage
- Anchorage Oncology Centre - Anchorage
- Katmai Oncology Group - Anchorage
- Providence Alaska Medical Center - Anchorage
Idaho
- Saint Alphonsus Cancer Care Center-Boise - Boise
- Saint Luke's Cancer Institute - Boise - Boise
- Saint Alphonsus Cancer Care Center-Caldwell - Caldwell
- Kootenai Health - Coeur d'Alene - Coeur d'Alene
Georgia
- Emory University Hospital Midtown - Atlanta
- Emory University Hospital/Winship Cancer Institute - Atlanta
- Emory Saint Joseph's Hospital - Atlanta
Arkansas
- Mercy Hospital Fort Smith - Fort Smith
- CARTI Cancer Center - Little Rock
California
- Providence Saint Joseph Medical Center/Disney Family Cancer Center - Burbank
District of Columbia
- MedStar Georgetown University Hospital - Washington D.C.
Florida
- Holy Cross Hospital - Fort Lauderdale
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 46 participants |
| Start Date | 2018-04-25 |
| Est. Completion | 2027-06-30 |
| Phase | Phase 2 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03191149
The ClinicalTrials.gov registry entry for NCT03191149 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 46 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 118-participant average among 30 other Recurrent Lung Non-Small Cell Carcinoma trials with a reported enrollment target (61% lower). The listed sponsor is National Cancer Institute (NCI), which has 3,257 total studies on file at ClinicalTrials.gov.
The record links to 4 conditions, with Recurrent Lung Non-Small Cell Carcinoma appearing as the primary indexed condition, and to 5 interventions - of which Biospecimen Collection is the first listed.
NCT03191149 reports 20 study locations spanning 7 distinct geographic areas - top geographies include Alaska, Idaho, Georgia.
Frequently Asked Questions
What is clinical trial NCT03191149 about?
NCT03191149 is a clinical study titled "Testing Osimertinib as a Treatment for Lung Cancers With an EGFR Exon 20 Change". This phase II trial studies how well osimertinib works in treating patients with non-small cell lung cancer with EGFR exon 20 insertion mutation that is stage IIIB-IV or has come back after a period of improvement (recurrent). Osimertinib may stop the growth of tumor cells by blocking some of the en...
What is the current status of trial NCT03191149?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 46 participants. The study started on 2018-04-25. Estimated completion is 2027-06-30.
What conditions does trial NCT03191149 study?
This clinical trial studies the following conditions: Recurrent Lung Non-Small Cell Carcinoma, Advanced Lung Non-Small Cell Carcinoma, Stage IV Lung Non-Small Cell Cancer AJCC v7, Stage IIIB Lung Non-Small Cell Cancer AJCC v7.
What interventions are being tested in trial NCT03191149?
The interventions under investigation include: Biospecimen Collection (PROCEDURE), Magnetic Resonance Imaging (PROCEDURE), Echocardiography Test (PROCEDURE), Multigated Acquisition Scan (PROCEDURE), Computed Tomography with Contrast (PROCEDURE).
Who is sponsoring clinical trial NCT03191149?
This trial is sponsored by National Cancer Institute (NCI), which has 3,257 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03191149 being conducted?
This trial has 20 study locations across Alaska, Arkansas, California, District of Columbia, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Recurrent Lung Non-Small Cell Carcinoma
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