Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

ACTIVE NOT RECRUITING Phase 2

Targeted Treatment for RET Fusion-Positive Advanced Non-Small Cell Lung Cancer (A LUNG-MAP Treatment Trial)

NCT04268550 · View on ClinicalTrials.gov ↗

Study Summary

This phase II LUNG-MAP treatment trial studies how well selpercatinib works in treating patients with RET fusion-positive non-small cell lung cancer that is stage IV or has come back (recurrent). Selpercatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Interventions

  • DRUG Selpercatinib

Study Locations (20)

California

  • Kaiser Permanente-Anaheim — Anaheim
  • Sutter Auburn Faith Hospital — Auburn
  • Kaiser Permanente-Baldwin Park — Baldwin Park
  • Kaiser Permanente-Bellflower — Bellflower
  • Alta Bates Summit Medical Center-Herrick Campus — Berkeley
  • Kaiser Permanente-Fontana — Fontana
  • Palo Alto Medical Foundation-Fremont — Fremont
  • Kaiser Permanente - Harbor City — Harbor City
  • Kaiser Permanente-Irvine — Irvine
  • Loma Linda University Medical Center — Loma Linda
  • Kaiser Permanente Los Angeles Medical Center — Los Angeles
  • Kaiser Permanente-Cadillac — Los Angeles
  • Palo Alto Medical Foundation-Camino Division — Mountain View
  • Kaiser Permanente-Ontario — Ontario
  • Palo Alto Medical Foundation Health Care — Palo Alto
  • Stanford Cancer Institute Palo Alto — Palo Alto
  • Kaiser Permanente - Panorama City — Panorama City
  • Kaiser Permanente-Riverside — Riverside

Alaska

  • Fairbanks Memorial Hospital — Fairbanks

Arkansas

  • University of Arkansas for Medical Sciences — Little Rock

Trial Details

FieldValue
Enrollment Target 124 participants
Start Date 2020-04-08
Est. Completion 2026-12-01
Phase Phase 2

Sponsor

SWOG Cancer Research Network

212 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04268550

The ClinicalTrials.gov registry entry for NCT04268550 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 124 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is SWOG Cancer Research Network, which has 212 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 4 conditions, with Stage IV Lung Cancer AJCC v8 appearing as the primary indexed condition, and to 1 intervention — of which Selpercatinib is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04268550 reports 20 study locations spanning 3 distinct geographic areas — top geographies include California, Alaska, Arkansas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04268550 about?

NCT04268550 is a clinical study titled "Targeted Treatment for RET Fusion-Positive Advanced Non-Small Cell Lung Cancer (A LUNG-MAP Treatment Trial)". This phase II LUNG-MAP treatment trial studies how well selpercatinib works in treating patients with RET fusion-positive non-small cell lung cancer that is stage IV or has come back (recurrent). Selpercatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

What is the current status of trial NCT04268550?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 124 participants. The study started on 2020-04-08. Estimated completion is 2026-12-01.

What conditions does trial NCT04268550 study?

This clinical trial studies the following conditions: Stage IV Lung Cancer AJCC v8, Stage IVA Lung Cancer AJCC v8, Stage IVB Lung Cancer AJCC v8, Recurrent Lung Non-Small Cell Carcinoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04268550?

The interventions under investigation include: Selpercatinib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04268550?

This trial is sponsored by SWOG Cancer Research Network, which has 212 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04268550 being conducted?

This trial has 20 study locations across Alaska, Arkansas, California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial